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Does stored salt in the skin drive high blood pressure?

NCT ID NCT04319068

Knowledge-focused Sponsor: Jens Titze Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This study looks at whether the body stores salt in the skin and muscles, and if that stored salt is linked to higher blood pressure. Researchers will compare healthy people with those who have hypertension, using MRI scans to measure salt content. They will also check if people with a skin protein mutation that causes more water loss through the skin have more salt stored and higher blood pressure. The goal is to understand how salt storage might affect cardiovascular risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it works, this could point toward new ways to predict or manage high blood pressure by measuring salt stored in the skin and muscles.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply beyond the Singaporean population studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Dec 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Eligible participants from the Biobank cohort at the National Heart Centre, Singapore, will be screened and estimated 600 subjects (healthy controls and hypertensive patients) will be recruited for the study over a period of 3 years. No ethnic group or gender is targeted for or excluded from this reasearch.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants from the Biobank (Molecular and Imaging Studies of Cardiovascular Health and Disease) cohort in Singapore, who agreed to be contacted for further studies 2. Male and female patients older than 21 years 3. Willingness to participate and ability to provide informed consent Exclusion Criteria: 1. Patients with exclusion criteria for the MRI, such as: 1. implanted devices (surgical clips, heart pacemakers or defibrillators, cochlear implants) 2. iron-based tattoos 3. any other pieces of metal or devices that are not MR-Safe anywhere in the body 4. patients who exhibit noticeable anxiety and/or claustrophobia into the MRI scanner 2. Pregnant women 3. Diagnosis of heart failure NYHA classes III and IV 4. Impaired renal function with eGFR\<45 ml/min or proteinuria \> 0.5 g/24h 5. Liver disease with cirrhosis (Child-Pugh class C) or hypoalbuminemia 6. Peripheral oedema as assessed by the investigator 7. Active cancer 8. Patients who have received an organ or bone marrow transplant 9. Patients who have had major surgery in the past 3 months 10. Patients who have severe comorbid conditions likely to compromise survival or study participation 11. Unwillingness or other inability to cooperate

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Hypertension

Contacts and locations

Locations

  • Duke-NUS Medical School

    Singapore, 169857, Singapore

  • National Heart Centre Singapore

    Singapore, 169609, Singapore

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