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Sleep apnea patients stop CPAP for 2 weeks – Here's what scientists learned

NCT ID NCT05920083

Knowledge-focused Sponsor: Raphael Heinzer Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study involved 65 adults with obstructive sleep apnea who had been using CPAP therapy for at least 6 months. Participants stopped using CPAP for 2 weeks so researchers could measure changes in blood vessel function and nerve control of the heart. The goal was to see if a specific sleep measurement could predict how the body responds to stopping treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Jan 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years old * Diagnosed with OSA (AHI ≥15 events/h), confirmed during screening period * Adequately treated with CPAP therapy for ≥6 months * Able to give informed consent as documented by signature Exclusion Criteria: * Professional drivers will be excluded from the study because temporary withdrawal of CPAP may induce drowsiness. * We will also exclude patients with conditions that may affect endothelial and autonomic function: * Known Diabetes * Known heart failure * Known chronic kidney disease * Pregnant or lactating women * Morbid obesity (≥40 kg/m2) * Known Excessive alcohol consumption * Known Dementia (especially dementia with Lewy bodies). (61) * Patients using alpha and beta blockers * Known atrial fibrillation * Inability to follow the procedures of the study due to language problems or psychological disorders.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea

Contacts and locations

Locations

  • Lausanne University Hospital

    Lausanne, Canton of Vaud, 1012, Switzerland

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