New hope for lung cancer patients who can't use standard immunotherapy alone
NCT ID NCT06711900
First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times
Summary
This study tests whether adding the experimental drug SKB264 to the immunotherapy pembrolizumab works better than standard chemotherapy plus pembrolizumab for people with advanced non-squamous lung cancer that lacks the PD-L1 protein. About 432 adults with stage IIIB/IV disease who haven't had prior treatment will be enrolled. The goal is to see if the new combination delays cancer growth and improves survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, China
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Affiliated Hospital of Guilin Medical University
Guilin, China
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Affiliated Hospital of North Sichuan Medical College
Nanchong, China
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Affiliated Tumor Hospital of Xinjiang Medical University
Ürümqi, China
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Anhui Provincial Chest Hospital
Hefei, China
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Army Medical Center of PLA (Daping Hospital)
Chongqing, China
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Beijing Cancer Hospital
Beijing, China
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Beijing Chest Hospital. Capital Medical University
Beijing, China
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Cancer Hospital Chinese Academy of Medical Sciences
Beijing, China
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Chengdu Fifth People's Hospital
Chengdu, China
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China Medical University First Affiliated Hospital
Shenyang, China
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Chongqing University Cancer Hospital
Chongqing, China
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First Affiliated Hospital of Gannan Medical University
Ganzhou, China
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Fujian Cancer Hospital
Fuzhou, China
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Gansu Provincial Cancer Hospital
Lanzhou, China
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General Hospital of Ningxia Medical University
Yinchuan, China
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Guangxi Medical University Cancer Hospital
Nanning, China
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Harbin Medical University Cancer Hospital
Ha’erbin, China
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Henan Cancer Hospital
Zhengzhou, China
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Huashan Hospital Affiliated to Fudan University
Shanghai, China
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Hubei Cancer Hospital
Wuhan, China
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Hunan Cancer Hospital
Changsha, China
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Jiangsu Cancer Hospital
Nanjing, China
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Jiangsu Province Hospital
Nanjing, China
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Jiangxi Cancer Hospital
Nanchang, China
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Jilin Cancer Hospital
Changcun, China
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Liaoning Cancer Hospital
Shenyang, China
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Linyi Cancer Hospital
Linyi, China
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Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Mianyang, China
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Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Nanjing, China
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Peking University Third Hospital
Beijing, China
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People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China
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Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
Jinan, China
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Shandong Provincial Hospital
Jinan, China
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Shanghai Chest Hospital
Shanghai, China
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Shanghai Oriental Hospital
Shanghai, China
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Shanghai Pulmonary Hospital
Shanghai, China
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Shanxi Province Cancer Hospital
Taiyuan, China
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Shengjing Hospital, China Medical University
Shengyang, China
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Sichuan Provincial People's Hospital
Chengdu, China
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Sir Run Run Shaw Hospital (SRRSH)
Hangzhou, China
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Sun Yat-sen University Cancer Center
Guangzhou, China
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Taizhou Hospital of Zhejiang Province
Taizhou, China
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The 2nd Affiliated Hospital of Harbin Medical University
Ha’erbin, China
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The 900 Hospital of the Joint Logistics Support Force of the People's Liberation Army of China
Fuzhou, China
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The Affiliated Hospital of Qingdao University
Qingdao, China
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The First Affiliated Hospital Of Xiamen University
Xiamen, China
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The First Affiliated Hospital of Guangxi Medical University
Nanning, China
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The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
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The First Affiliated Hospital of Henan University of Science & Technology,
Luoyang, China
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The First Affiliated Hospital of Nanchang University
Nanchang, China
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The First Affiliated Hospital of XiAn Jiaotong University
Xi'an, China
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The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
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The First Hospital of Jilin University
Changchun, China
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The Fourth Hospital of Hebei Medical University
Shijiazhuang, China
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The General Hospital of Western Theater Command
Chengdu, China
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The Second Affiliated Hospital Of Anhui Medical University
Hefei, China
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The Second Affiliated Hospital Of Zunyi Medical University
Zunyi, China
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The Second Affiliated Hospital of Army Medical University
Chongqing, China
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The Second Affiliated Hospital of Dalian Medical University
Dalian, China
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The Second Affiliated Hospital of XiAn Jiaotong University
Xi'an, China
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The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
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The Second People's Hospital of Neijiang
Neijiang, China
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The Southwest Hospial Of AMU
Chongqing, China
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The Third Affiliated Hospital of Kunming Medical University
Kunming, China
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Tianjin Medical University Cancer Institute and Hospital
Tianjin, China
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
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University of Electronic Science and Technology of China, Sichuan Cancer Hospital and Institute & Cancer, The Second People's Hospital of Sichuan Province
Chengdu, China
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Weifang People's Hospital
Weifang, China
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West China Hospital of Sichuan University
Chengdu, China
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Xiangya Hospital, Central South University
Changsha, China
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Xiangya Second Hospital of Central South University
Changsha, China
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Xiangyang Central Hospital
Xiangyang, China
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Yibin Second People's Hospital
Yibin, China
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Yuebei People's Hospital
Shaoguan, China
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Zhejiang Cancer Hospital
Hangzhou, China
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Zhongnan Hospital of Wuhan University
Wuhan, China
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Zhongshan Hospital of Fudan University
Shanghai, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Double attack on mutant KRAS: can two targeted drugs outsmart resistant cancers?
- Seeing the fight: new imaging tracer may reveal how immune cells attack lung cancer
- Could a bronchial wash detect lung cancer mutations faster?
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- Can a PET scan reveal hidden heart harm from lung cancer treatment?