New hope for lung cancer patients who can't use standard immunotherapy alone

NCT ID NCT06711900

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tests whether adding the experimental drug SKB264 to the immunotherapy pembrolizumab works better than standard chemotherapy plus pembrolizumab for people with advanced non-squamous lung cancer that lacks the PD-L1 protein. About 432 adults with stage IIIB/IV disease who haven't had prior treatment will be enrolled. The goal is to see if the new combination delays cancer growth and improves survival.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Affiliated Cancer Hospital and Institute of Guangzhou Medical University

    Guangzhou, China

  • Affiliated Hospital of Guilin Medical University

    Guilin, China

  • Affiliated Hospital of North Sichuan Medical College

    Nanchong, China

  • Affiliated Tumor Hospital of Xinjiang Medical University

    Ürümqi, China

  • Anhui Provincial Chest Hospital

    Hefei, China

  • Army Medical Center of PLA (Daping Hospital)

    Chongqing, China

  • Beijing Cancer Hospital

    Beijing, China

  • Beijing Chest Hospital. Capital Medical University

    Beijing, China

  • Cancer Hospital Chinese Academy of Medical Sciences

    Beijing, China

  • Chengdu Fifth People's Hospital

    Chengdu, China

  • China Medical University First Affiliated Hospital

    Shenyang, China

  • Chongqing University Cancer Hospital

    Chongqing, China

  • First Affiliated Hospital of Gannan Medical University

    Ganzhou, China

  • Fujian Cancer Hospital

    Fuzhou, China

  • Gansu Provincial Cancer Hospital

    Lanzhou, China

  • General Hospital of Ningxia Medical University

    Yinchuan, China

  • Guangxi Medical University Cancer Hospital

    Nanning, China

  • Harbin Medical University Cancer Hospital

    Ha’erbin, China

  • Henan Cancer Hospital

    Zhengzhou, China

  • Huashan Hospital Affiliated to Fudan University

    Shanghai, China

  • Hubei Cancer Hospital

    Wuhan, China

  • Hunan Cancer Hospital

    Changsha, China

  • Jiangsu Cancer Hospital

    Nanjing, China

  • Jiangsu Province Hospital

    Nanjing, China

  • Jiangxi Cancer Hospital

    Nanchang, China

  • Jilin Cancer Hospital

    Changcun, China

  • Liaoning Cancer Hospital

    Shenyang, China

  • Linyi Cancer Hospital

    Linyi, China

  • Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China

    Mianyang, China

  • Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

    Nanjing, China

  • Peking University Third Hospital

    Beijing, China

  • People's Hospital of Guangxi Zhuang Autonomous Region

    Nanning, China

  • Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

    Jinan, China

  • Shandong Provincial Hospital

    Jinan, China

  • Shanghai Chest Hospital

    Shanghai, China

  • Shanghai Oriental Hospital

    Shanghai, China

  • Shanghai Pulmonary Hospital

    Shanghai, China

  • Shanxi Province Cancer Hospital

    Taiyuan, China

  • Shengjing Hospital, China Medical University

    Shengyang, China

  • Sichuan Provincial People's Hospital

    Chengdu, China

  • Sir Run Run Shaw Hospital (SRRSH)

    Hangzhou, China

  • Sun Yat-sen University Cancer Center

    Guangzhou, China

  • Taizhou Hospital of Zhejiang Province

    Taizhou, China

  • The 2nd Affiliated Hospital of Harbin Medical University

    Ha’erbin, China

  • The 900 Hospital of the Joint Logistics Support Force of the People's Liberation Army of China

    Fuzhou, China

  • The Affiliated Hospital of Qingdao University

    Qingdao, China

  • The First Affiliated Hospital Of Xiamen University

    Xiamen, China

  • The First Affiliated Hospital of Guangxi Medical University

    Nanning, China

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, China

  • The First Affiliated Hospital of Henan University of Science & Technology,

    Luoyang, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, China

  • The First Affiliated Hospital of XiAn Jiaotong University

    Xi'an, China

  • The First Affiliated Hospital of Xinxiang Medical University

    Xinxiang, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, China

  • The First Hospital of Jilin University

    Changchun, China

  • The Fourth Hospital of Hebei Medical University

    Shijiazhuang, China

  • The General Hospital of Western Theater Command

    Chengdu, China

  • The Second Affiliated Hospital Of Anhui Medical University

    Hefei, China

  • The Second Affiliated Hospital Of Zunyi Medical University

    Zunyi, China

  • The Second Affiliated Hospital of Army Medical University

    Chongqing, China

  • The Second Affiliated Hospital of Dalian Medical University

    Dalian, China

  • The Second Affiliated Hospital of XiAn Jiaotong University

    Xi'an, China

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, China

  • The Second People's Hospital of Neijiang

    Neijiang, China

  • The Southwest Hospial Of AMU

    Chongqing, China

  • The Third Affiliated Hospital of Kunming Medical University

    Kunming, China

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, China

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, China

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, China

  • University of Electronic Science and Technology of China, Sichuan Cancer Hospital and Institute & Cancer, The Second People's Hospital of Sichuan Province

    Chengdu, China

  • Weifang People's Hospital

    Weifang, China

  • West China Hospital of Sichuan University

    Chengdu, China

  • Xiangya Hospital, Central South University

    Changsha, China

  • Xiangya Second Hospital of Central South University

    Changsha, China

  • Xiangyang Central Hospital

    Xiangyang, China

  • Yibin Second People's Hospital

    Yibin, China

  • Yuebei People's Hospital

    Shaoguan, China

  • Zhejiang Cancer Hospital

    Hangzhou, China

  • Zhongnan Hospital of Wuhan University

    Wuhan, China

  • Zhongshan Hospital of Fudan University

    Shanghai, China

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