New Low-Toxicity transplant could cure sickle cell in kids
NCT ID NCT03587272
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new, gentler stem cell transplant for children with sickle cell disease using a combination of drugs and low-dose radiation. The goal is to cure the disease with fewer side effects than standard transplants. About 100 children will receive a transplant from a healthy sibling donor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Alemtuzumab, low-dose total body irradiation, and sirolimus
- What this could lead to
- If successful, this could offer a safer, curative stem cell transplant for children with sickle cell disease, reducing long-term health problems.
- What could go wrong
- This is an early phase 2 trial with only 100 participants, so results may not apply to all. Risks include graft rejection, graft-versus-host disease, and infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alberta Children's Hospital
RECRUITINGCalgary, Alberta, T3B 6A8, Canada
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Children's National Health System
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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Levine Children's Hospital
RECRUITINGCharlotte, North Carolina, 28203, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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The Hospital for Sick Children
RECRUITINGToronto, Ontario, M5G 1X8, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Co-Designed support help parents embrace sickle cell care?
- Can community hospitals in zambia master severe disease care?
- A Pocket-Sized coach for sickle cell: can an app turn Pill-Taking into a habit?
- Can a phone app keep teens on track with sickle cell treatment?
- A common amino acid may calm sickle cell pain crises — a trial puts it to the test
- A drug that protects the liver may make stem cell transplants safer for children with sickle cell disease