Massive sickle cell study aims to unlock secrets of organ damage
NCT ID NCT02098863
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will follow 10,000 people with sickle cell disease for many years, tracking their health during regular clinic visits. Researchers want to learn how the disease damages organs over time and how treatments like hydroxyurea might help prevent that damage. A smaller part of the study will also look at how genes affect response to hydroxyurea.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal how to prevent long-term organ damage in sickle cell disease and identify who benefits most from hydroxyurea.
What could go wrong
This is an observational study, not a treatment trial. It collects data over many years, so results will take time and may not lead to immediate changes in care.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital of Illinois at OSF-Saint Francis Medical Center
RECRUITINGPeoria, Illinois, 61637, United States
Contact Phone: •••-•••-••••
Contact
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Methodist Adult Comprehensive Sickle Cell Center
RECRUITINGMemphis, Tennessee, 38104, United States
Contact
Contact Phone: •••-•••-••••
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Novant Health Hemby Children's Hospital
RECRUITINGCharlotte, North Carolina, 28204, United States
Contact
Contact Phone: •••-•••-••••
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Our Lady of the Lake Regional Medical Center
COMPLETEDBaton Rouge, Louisiana, 70808, United States
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Regional One Health, Diggs-Kraus Sickle Cell Center
RECRUITINGMemphis, Tennessee, 38103, United States
Contact
Contact Phone: •••-•••-••••
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St. Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact