Sickle cell breakthrough: can curative therapies heal damaged organs?

NCT ID NCT05213572

Recruiting now Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at adults with sickle cell disease to see how their heart, brain, kidneys, liver, and lungs change after treatments meant to cure the disease. Researchers will compare people getting curative therapy (like a bone marrow transplant or gene therapy) with those who are not. Participants undergo tests like MRIs, blood work, and lung function tests at the start and again after two years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Death, Sudden sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MORTALITY IN SICKLE CELL SICKLE CELL CARDIOPULMONARY COMPLICATIONS SICKLE CELL LIFE EXPECTANCY AND RISK FACTORS FOR EARLY DEATH SICKLE CELL LUNG DISEASE AND SUDDEN DEATH SICKLE CELL ORGAN DAMAGE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••