Can a Two-Drug combo keep Limited-Stage lung cancer at bay?
NCT ID NCT07798947
First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether combining an experimental drug called SHR-7787 with the immunotherapy adebrelimab can help people with limited-stage small cell lung cancer. The study enrolls adults aged 18 to 75 whose cancer has not progressed after standard chemotherapy and radiation. Researchers will measure how long participants live without the cancer worsening, as well as overall survival and side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- SHR-7787 injection combined with adebrelimab (an immunotherapy drug)
- What this could lead to
- If it works, this combination could help keep limited-stage small cell lung cancer from growing back after standard treatment, possibly extending the time people live without the cancer progressing.
- What could go wrong
- This is an early-phase trial with a modest number of participants, so the benefits are unproven. The combination may cause side effects, and results may not hold up in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Voluntarily participate in this clinical study, understand the study procedures, and be able to sign the informed consent form (ICF) in writing. 2. Aged 18 to 75 years (inclusive), of any gender. 3. Histologically or cytologically confirmed unresectable limited-stage small cell lung cancer (LS-SCLC) whose disease has not progressed following platinum-based chemotherapy and radiation therapy. 4. ECOG performance status score of 0 or 1. 5. Estimated survival time of more than 3 months. 6. Have adequate bone marrow and organ function. 7. Female trial participants of childbearing potential must agree to use highly effective contraception from the time of signing the informed consent form until 6 months after the last dose of the investigational drug, and avoid donating eggs. Exclusion Criteria: 1. Combined small cell lung cancer or any transformed small cell lung cancer. 2. History of other malignancies within 5 years prior to the first dose of the study drug. 3. Severe cardiovascular or cerebrovascular diseases. 4. Bleeding symptoms of significant clinical relevance within 3 months prior to the first dose of the study drug. 5. Malignant pleural effusion or malignant pericardial effusion. 6. Severe infection within 4 weeks prior to the initiation of study treatment. 7. Active tuberculosis infection within 1 year prior to enrollment, identified by medical history or imaging examination. 8. History of immunodeficiency. 9. Active, known, or suspected autoimmune disease, or a history of autoimmune disease. 10. Prior treatment with immune checkpoint inhibitors (ICIs). 11. Undergone major organ surgery within 4 weeks prior to the first dose of the study drug. 12. Any other factors that, in the judgment of the investigator, may affect the study results or force premature termination of the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Cancer Hospital of Shandong First Medical University
Jinan, Shandong, 250117, China
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