New combo therapy aims to wipe out rectal tumors before surgery

NCT ID NCT04928807

First seen Feb 28, 2026 · Last updated Apr 25, 2026 · Updated 7 times

Summary

This study compares a new treatment approach for locally advanced rectal cancer: short-course radiation followed by chemotherapy and the immunotherapy drug camrelizumab, versus the standard long-course chemoradiation. About 230 adults with stage T3-4 or node-positive rectal cancer will participate. The main goal is to see if the new combination leads to a higher rate of complete tumor disappearance at the time of surgery.

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Contacts and locations

Locations

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, China

Conditions

Explore the condition pages connected to this study.