Muscle recovery differs between sexes, new study reveals

NCT ID NCT04151901

Ongoing Knowledge-focused Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how middle-aged men and women lose muscle after a week of not using one leg, and how they recover with exercise. Researchers will measure muscle strength, size, and genetic activity to find sex-specific differences. The goal is to learn more so future treatments can be tailored to each sex.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Resistance exercise rehabilitation and walking-based rehabilitation
What this could lead to: If successful, this could help design better, sex-specific rehabilitation programs for middle-aged people after periods of inactivity.
What could go wrong: This is a small, early-phase study with only 37 participants, so results may not apply to everyone. It focuses on understanding mechanisms, not on testing a new treatment.

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Conditions

The condition(s) this trial relates to.

muscular atrophy Muscular Disorders, Atrophic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATROPHY OF MUSCLE DUE TO DISUSE REHABILITATION

Contacts and locations

Locations

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Texas Medical Branch

Galveston, Texas, 77555, United States

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