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Can we predict dangerous heart ablation risks?

NCT ID NCT07777744

Knowledge-focused Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This international study looks at data from thousands of patients who had ablation procedures for ventricular tachycardia or premature ventricular complexes—heart rhythm problems. The goal is to understand how often severe complications like stroke, cardiac arrest, or major bleeding occur, and what patient or procedure factors might be linked to them. By pooling existing data from many medical centers, researchers hope to identify patterns that could help improve safety in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
This research could help doctors better predict and prevent rare but serious complications from heart ablation procedures, improving patient safety.
What could go wrong
Because this is an observational study using existing data, it cannot prove cause and effect, and the findings may not apply to all centers or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 15,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting with a severe VT/PVC-ablation-related complication

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Centers : Centers participating in the present collaborative study group. Invitation to participate will be based either upon personal referral of one of the investigator, previous collaboration or based on a meta-analytic review of the literature published on the subject within the past 20 years. * Patients: Females and males of \>18 years undergoing any type of VT/PVC ablation. While we will accept redo-procedure we will ask for a unique patient-identifier to link procedures belonging to the same patients together. * Interventions: VT/PVC ablation (first intervention or re-do) as routinely performed by the participating centers * Outcomes: Severe complications, defined as hemodynamic instability requiring mechanical intensive-care management, tamponade, stroke, cardiac arrest, myocardial infarction, phrenic nerve palsies, major bleeding requiring transfusion, vascular or cardiac complication requiring surgery, procedure-related death. * Setting: Observational cohort studies, registries, retrospective cohort studies. Data stemming from RCTs (Randomized controlled trials) will not be collected as they likely do not represent a "real-life" setting. * Length of follow-up: Peri-procedural complications * Years considered: Not limited to a specific time-frame, but to reflect common ablation practices, we will focus on data from the 20 past years. * Number of patients provided : No lower limit of patients provided per dataset or ablation volume per year to include high- as well as low-volume centers Exclusion Criteria: * Refusal of the center to participate. * Less than 10 procedures available in the dataset (no case reports) * Missing essential baseline characteristics, missing collection of sufficient details regarding each complication.

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Conditions

The condition(s) this trial relates to.

Ventricular Premature Complexes ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Premature ventricular complexes Ventricular tachycardia (VT)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    25 sites in 16 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara City Hospital

    RECRUITING

    Ankara, Turkey (Türkiye)

  • CHU Bordeaux

    RECRUITING

    Bordeaux, France

  • Carl-Thiem-Klinikum

    RECRUITING

    Cottbus, Germany

  • Centre Hospitalier Universitaire Trousseau

    RECRUITING

    Chambray-lès-Tours, France

  • Citta della Salute e della Scienza di Torino

    RECRUITING

    Torino, Italy

  • Clinique Pasteur Toulouse

    RECRUITING

    Toulouse, France

  • Hacettepe University

    RECRUITING

    Ankara, Turkey (Türkiye)

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Spain

  • Inselspital Bern

    RECRUITING

    Bern, Switzerland

  • Medical University of Graz

    RECRUITING

    Graz, Austria

  • Mount Elisabeth Medical Centre

    RECRUITING

    Singapore, Singapore

  • Royal Papworth Hospital

    RECRUITING

    Cambridge, United Kingdom

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, Israel

  • The First Affiliated Hospital of Nanjing Medical University

    RECRUITING

    Nanjing, China

  • Uniklinik Freiburg

    RECRUITING

    Bad Krozingen, Germany

  • University Hospital Basel

    RECRUITING

    Basel, 4031, Switzerland

  • University Hospital Center Sestre milosrdnice

    RECRUITING

    Zagreb, Croatia

  • University Hospital Poitier

    RECRUITING

    Poitiers, France

  • University Medical Center Ljubljana

    RECRUITING

    Ljubljana, Slovenia

  • University of Michigan

    RECRUITING

    Michigan Center, Michigan, 48109, United States

  • University of Patras

    RECRUITING

    Pátrai, Greece

  • Universitätsklinikum Münster

    RECRUITING

    Münster, Germany

  • Université Laval

    RECRUITING

    Québec, Canada

  • Zentralklinik Bad Bercka

    RECRUITING

    Bad Berka, Germany

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