New asthma shot aims to match leading treatments in major trial

NCT ID NCT04718389

Completed Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 study tested if switching to a new, long-acting injection called GSK3511294 (depemokimab) was as good as staying on current treatments (mepolizumab or benralizumab) for controlling severe asthma flare-ups. It involved over 1,700 teens and adults with a specific type of severe asthma who were already benefiting from one of those current injections. The main goal was to see if the new treatment could keep asthma just as well-controlled over a full year.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

GSK Investigational Site

Birmingham, Alabama, 35209, United States
GSK Investigational Site

Scottsboro, Alabama, 35768, United States
GSK Investigational Site

Litchfield Park, Arizona, 85340, United States
GSK Investigational Site

Phoenix, Arizona, 85054, United States
GSK Investigational Site

Scottsdale, Arizona, 85251, United States
GSK Investigational Site

Bakersfield, California, 93301, United States
GSK Investigational Site

Encinitas, California, 92024, United States
GSK Investigational Site

Huntington Beach, California, 92647, United States
GSK Investigational Site

Los Angeles, California, 90048, United States
GSK Investigational Site

Newport Beach, California, 92663, United States
GSK Investigational Site

Oxnard, California, 93036, United States
GSK Investigational Site

Rancho Cucamonga, California, 91730, United States
GSK Investigational Site

Redondo Beach, California, 90277, United States
GSK Investigational Site

Redwood City, California, 94063, United States
GSK Investigational Site

Riverside, California, 91786, United States
GSK Investigational Site

San Diego, California, 92123, United States
GSK Investigational Site

San Diego, California, 92307, United States
GSK Investigational Site

Valencia, California, 91324, United States
GSK Investigational Site

Woodland, California, 95695, United States
GSK Investigational Site

Aurora, Colorado, 80238, United States
GSK Investigational Site

Colorado Springs, Colorado, 80907, United States
GSK Investigational Site

Colorado Springs, Colorado, 80923, United States
GSK Investigational Site

Denver, Colorado, 80209, United States
GSK Investigational Site

Wheat Ridge, Colorado, 80033, United States
GSK Investigational Site

New Haven, Connecticut, 06511, United States
GSK Investigational Site

Aventura, Florida, 33180, United States
GSK Investigational Site

Clearwater, Florida, 33765-2103, United States
GSK Investigational Site

Fort Lauderdale, Florida, 33316, United States
GSK Investigational Site

Gainesville, Florida, 32610, United States
GSK Investigational Site

Hialeah, Florida, 33014, United States
GSK Investigational Site

Hialeah, Florida, 33016, United States
GSK Investigational Site

Jacksonville, Florida, 32209, United States
GSK Investigational Site

Kissimmee, Florida, 34746, United States
GSK Investigational Site

Loxahatchee Groves, Florida, 33470, United States
GSK Investigational Site

Miami, Florida, 33125, United States
GSK Investigational Site

Miami, Florida, 33126, United States
GSK Investigational Site

Miami, Florida, 33144, United States
GSK Investigational Site

Miami, Florida, 33166, United States
GSK Investigational Site

Miami, Florida, 33172, United States
GSK Investigational Site

Miami, Florida, 33186, United States
GSK Investigational Site

Miami Lakes, Florida, 33014, United States
GSK Investigational Site

Miami Lakes, Florida, 33125, United States
GSK Investigational Site

North Palm Beach, Florida, 33408, United States
GSK Investigational Site

Orlando, Florida, 32803, United States
GSK Investigational Site

Orlando, Florida, 32806, United States
GSK Investigational Site

Orlando, Florida, 32819, United States
GSK Investigational Site

Sebring, Florida, 33870, United States
GSK Investigational Site

Tallahassee, Florida, 32308, United States
GSK Investigational Site

Calhoun, Georgia, 30701, United States
GSK Investigational Site

Glenview, Illinois, 60077, United States
GSK Investigational Site

Evansville, Indiana, 47715, United States
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Overland Park, Kansas, 66210, United States
GSK Investigational Site

Lexington, Kentucky, 40509, United States
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Owensboro, Kentucky, 42301, United States
GSK Investigational Site

Bangor, Maine, 04401, United States
GSK Investigational Site

Baltimore, Maryland, 21162, United States
GSK Investigational Site

Baltimore, Maryland, 21224, United States
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Chevy Chase, Maryland, 20815, United States
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Boston, Massachusetts, 02115, United States
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Burlington, Massachusetts, 01805, United States
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New Bedford, Massachusetts, 02740, United States
GSK Investigational Site

North Dartmouth, Massachusetts, 02747, United States
GSK Investigational Site

Ann Arbor, Michigan, 48109, United States
GSK Investigational Site

Flint, Michigan, 48507, United States
GSK Investigational Site

Warren, Michigan, 48088, United States
GSK Investigational Site

Minneapolis, Minnesota, 55454, United States
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Gulfport, Mississippi, 36608, United States
GSK Investigational Site

Jackson, Mississippi, 39216, United States
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Chesterfield, Missouri, 63017, United States
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Saint Charles, Missouri, 63301, United States
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St Louis, Missouri, 63110, United States
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Lincoln, Nebraska, 68505, United States
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Omaha, Nebraska, 68198-5990, United States
GSK Investigational Site

Brick, New Jersey, 08724, United States
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Northfield, New Jersey, 08225, United States
GSK Investigational Site

Riverdale, New Jersey, 07457, United States
GSK Investigational Site

Toms River, New Jersey, 08755, United States
GSK Investigational Site

Brooklyn, New York, 11215, United States
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Corning, New York, 14845, United States
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Great Neck, New York, 11040, United States
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New York, New York, 60301, United States
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The Bronx, New York, 10459-2417, United States
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The Bronx, New York, 10467, United States
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Asheville, North Carolina, 28803, United States
GSK Investigational Site

Huntersville, North Carolina, 28078, United States
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Wilmington, North Carolina, 28401, United States
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Winston-Salem, North Carolina, 27103, United States
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Winston-Salem, North Carolina, 27157, United States
GSK Investigational Site

Cincinnati, Ohio, 45229, United States
GSK Investigational Site

Cincinnati, Ohio, 45231, United States
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Corvallis, Oregon, 97330, United States
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Altoona, Pennsylvania, 15801, United States
GSK Investigational Site

Altoona, Pennsylvania, 16601, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19140, United States
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Pittsburgh, Pennsylvania, 15241, United States
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Wyomissing, Pennsylvania, 19610, United States
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Warwick, Rhode Island, 02886, United States
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Rock Hill, South Carolina, 29732, United States
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Spartanburg, South Carolina, 29303, United States
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Hendersonville, Tennessee, 37075, United States
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Knoxville, Tennessee, 37909, United States
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Amarillo, Texas, 79106, United States
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Amarillo, Texas, 79124, United States
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Dallas, Texas, 75225, United States
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Dallas, Texas, 75235, United States
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Dallas, Texas, 75246, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77429, United States
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Kerrville, Texas, 78028, United States
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San Antonio, Texas, 78207, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78258, United States
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Murray, Utah, 84107, United States
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Richmond, Virginia, 23298, United States
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Williamsburg, Virginia, 23188, United States
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Bellingham, Washington, 98225, United States
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Seattle, Washington, 98115, United States
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Greenfield, Wisconsin, 53228, United States
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Macquarie Park, New South Wales, 2109, Australia
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Sydney, New South Wales, 2010, Australia
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Westmead, New South Wales, 2145, Australia
GSK Investigational Site

Cairns, Queensland, 4870, Australia
GSK Investigational Site

South Brisbane, Queensland, 4101, Australia
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Adelaide, South Australia, 5000, Australia
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Bedford Park, South Australia, 5042, Australia
GSK Investigational Site

North Adelaide, South Australia, 5006, Australia
GSK Investigational Site

Toorak Gardens, South Australia, 5065, Australia
GSK Investigational Site

Woodville, South Australia, 5011, Australia
GSK Investigational Site

Box Hill, Victoria, 3128, Australia
GSK Investigational Site

Clayton, Victoria, 3168, Australia
GSK Investigational Site

Fitzroy, Victoria, 3065, Australia
GSK Investigational Site

Frankston, Victoria, 3199, Australia
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Melbourne, Victoria, 3181, Australia
GSK Investigational Site

Nedlands, Western Australia, 6009, Australia
GSK Investigational Site

Feldbach, 8330, Austria
GSK Investigational Site

Vienna, 1130, Austria
GSK Investigational Site

Calgary, Alberta, T2N 4Z6, Canada
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Edmonton, Alberta, T5J 3S9, Canada
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Moncton, New Brunswick, E1C 5K4, Canada
GSK Investigational Site

Ajax, Ontario, L1S 2J5, Canada
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Ottawa, Ontario, K1H 1E4, Canada
GSK Investigational Site

Toronto, Ontario, M5G 1E2, Canada
GSK Investigational Site

Toronto, Ontario, M5T 3A9, Canada
GSK Investigational Site

Windsor, Ontario, N8X 1T3, Canada
GSK Investigational Site

Greenfield Park, Quebec, J4V 2H1, Canada
GSK Investigational Site

Québec, Quebec, G1V 4G5, Canada
GSK Investigational Site

Québec, Quebec, G1V 4W2, Canada
GSK Investigational Site

Trois-Rivières, Quebec, G8T 7A1, Canada
GSK Investigational Site

Tampere, 33520, Finland
GSK Investigational Site

Turku, 20521, Finland
GSK Investigational Site

Amiens, 80000, France
GSK Investigational Site

Annecy, 74011, France
GSK Investigational Site

Antony, 92160, France
GSK Investigational Site

Besançon, 25030, France
GSK Investigational Site

Brest, 29609, France
GSK Investigational Site

Caen, 14033, France
GSK Investigational Site

Cannes, 06414, France
GSK Investigational Site

Cholet, 49300, France
GSK Investigational Site

Dijon, 21079, France
GSK Investigational Site

La Tronche, 38700, France
GSK Investigational Site

Le Mans, 72037, France
GSK Investigational Site

Lille, 59037, France
GSK Investigational Site

Lyon, 69317, France
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Marseille, 13003., France
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Marseille, 13015, France
GSK Investigational Site

Montfermeil, 93370, France
GSK Investigational Site

Montivilliers, 76290, France
GSK Investigational Site

Montpellier, 34295, France
GSK Investigational Site

Nice, 06001, France
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Paris, 75014, France
GSK Investigational Site

Paris, 75015, France
GSK Investigational Site

Paris, 75877, France
GSK Investigational Site

Pontoise, 95303, France
GSK Investigational Site

Rouen, 76031, France
GSK Investigational Site

Saint-Herblain, 44093, France
GSK Investigational Site

Strasbourg, 67091, France
GSK Investigational Site

Suresnes, 92150, France
GSK Investigational Site

Toulouse, 31059, France
GSK Investigational Site

Tours, 37044, France
GSK Investigational Site

Aschaffenburg, 63739, Germany
GSK Investigational Site

Bendorf, 56170, Germany
GSK Investigational Site

Berlin, 10969, Germany
GSK Investigational Site

Berlin, 12159, Germany
GSK Investigational Site

Berlin, 12203, Germany
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Bonn, 53119, Germany
GSK Investigational Site

Bonn, 53127, Germany
GSK Investigational Site

Darmstadt, 64283, Germany
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Frankfurt, 60389, Germany
GSK Investigational Site

Frankfurt, 60596, Germany
GSK Investigational Site

Fürstenwalde, 15517, Germany
GSK Investigational Site

Geesthacht, 21502, Germany
GSK Investigational Site

Halle, 06108, Germany
GSK Investigational Site

Halle, 06120, Germany
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Hamburg, 20354, Germany
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Hanover, 30625, Germany
GSK Investigational Site

Landsberg, 86899, Germany
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Leipzig, 04207, Germany
GSK Investigational Site

Leipzig, 04275, Germany
GSK Investigational Site

Leipzig, 04347, Germany
GSK Investigational Site

Lübeck, 23552, Germany
GSK Investigational Site

Lübeck, 23558, Germany
GSK Investigational Site

Magdeburg, 39120, Germany
GSK Investigational Site

Mainz, 55128, Germany
GSK Investigational Site

München, 81241, Germany
GSK Investigational Site

Neu-Isenburg, 63263, Germany
GSK Investigational Site

Rheine, 48431, Germany
GSK Investigational Site

Schleswig, 24837, Germany
GSK Investigational Site

Cork, T12 DFK4, Ireland
GSK Investigational Site

Dublin, D04 T6F4, Ireland
GSK Investigational Site

Dublin, D08 NHY1, Ireland
GSK Investigational Site

Beersheba, 8410101, Israel
GSK Investigational Site

Haifa, 34362, Israel
GSK Investigational Site

Jerusalem, 91031, Israel
GSK Investigational Site

Jerusalem, 91120, Israel
GSK Investigational Site

Kfar Saba, 44281, Israel
GSK Investigational Site

Petah Tikva, 49100, Israel
GSK Investigational Site

Ramat Gan, 52621, Israel
GSK Investigational Site

Tel Aviv, 64239, Israel
GSK Investigational Site

Zrifin, 70300, Israel
GSK Investigational Site

Bari, 70124, Italy
GSK Investigational Site

Bergamo, 24127, Italy
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Bologna, 40138, Italy
GSK Investigational Site

Brescia, 25123, Italy
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Catania, 95123, Italy
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Ferrara, 44124, Italy
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Florence, 50134, Italy
GSK Investigational Site

Genova, 16132, Italy
GSK Investigational Site

Mantova, 46100, Italy
GSK Investigational Site

Milan, 20122, Italy
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Milan, 20123, Italy
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Milan, 20132, Italy
GSK Investigational Site

Milan, 20162, Italy
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Modena, 41124, Italy
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Monserrato CA, 09042, Italy
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Napoli, 80131, Italy
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Padua, 35128, Italy
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Palermo, 90127, Italy
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Pavia, 27100, Italy
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Perugia, 06156, Italy
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Pisa, 56100, Italy
GSK Investigational Site

Reggio Emilia, 42100, Italy
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Roma, 168, Italy
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Salerno, 84131, Italy
GSK Investigational Site

Sassari, 7100, Italy
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Siena, 53100, Italy
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Torino, 10128, Italy
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Torrette AN, 60020, Italy
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Treviso, 31100, Italy
GSK Investigational Site

Trieste, 34139, Italy
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Verona, 37134, Italy
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Shibuya-Ku, Tokyo, 150-8935, Japan
GSK Investigational Site

Aichi, 454-8509, Japan
GSK Investigational Site

Aichi, 470-1192, Japan
GSK Investigational Site

Aichi, 489-8642, Japan
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Akita, 010-8543, Japan
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Ehime, 790-0024, Japan
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Fukuoka, 802-0052, Japan
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Fukuoka, 805-8508, Japan
GSK Investigational Site

Fukuoka, 806-8501, Japan
GSK Investigational Site

Fukuoka, 811-1394, Japan
GSK Investigational Site

Fukuoka, 813-0017, Japan
GSK Investigational Site

Fukuoka, 830-0011, Japan
GSK Investigational Site

Fukushima, 960-1295, Japan
GSK Investigational Site

Gifu, 509-6134, Japan
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Hiroshima, 734-8530, Japan
GSK Investigational Site

Hiroshima, 735-8585, Japan
GSK Investigational Site

Hiroshima, 737-0023, Japan
GSK Investigational Site

Hokkaido, 064-0804, Japan
GSK Investigational Site

Hyōgo, 650-0047, Japan
GSK Investigational Site

Hyōgo, 653-0013, Japan
GSK Investigational Site

Ibaraki, 302-0022, Japan
GSK Investigational Site

Ibaraki, 319-1113, Japan
GSK Investigational Site

Ishikawa, 920-0293, Japan
GSK Investigational Site

Kagawa, 762-8550, Japan
GSK Investigational Site

Kagoshima, 890-8520, Japan
GSK Investigational Site

Kanagawa, 231-8682, Japan
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Kanagawa, 232-0024, Japan
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Kanagawa, 236-0004, Japan
GSK Investigational Site

Kanagawa, 236-0051, Japan
GSK Investigational Site

Kanagawa, 254-8502, Japan
GSK Investigational Site

Mie, 510-8561, Japan
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Mie, 511-0061, Japan
GSK Investigational Site

Mie, 515-8544, Japan
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Miyagi, 981-8563, Japan
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Nagano, 386-8610, Japan
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Niigata, 951-8520, Japan
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Numakunai, 020-8505, Japan
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Okayama, 701-0304, Japan
GSK Investigational Site

Okayama, 702-8055, Japan
GSK Investigational Site

Osaka, 530-0012, Japan
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Osaka, 543-8555, Japan
GSK Investigational Site

Osaka, 560-8552, Japan
GSK Investigational Site

Osaka, 569-1096, Japan
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Osaka, 569-1192, Japan
GSK Investigational Site

Osaka, 569-8686, Japan
GSK Investigational Site

Osaka, 572-8551, Japan
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Osaka, 593-8304, Japan
GSK Investigational Site

Osaka, 596-8501, Japan
GSK Investigational Site

Shimane, 693-8501, Japan
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Shizuoka, 420-8527, Japan
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Shizuoka, 430-8525, Japan
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Tokyo, 103-0027, Japan
GSK Investigational Site

Tokyo, 105-8471, Japan
GSK Investigational Site

Tokyo, 113-8431, Japan
GSK Investigational Site

Tokyo, 113-8519, Japan
GSK Investigational Site

Tokyo, 136-0075, Japan
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Tokyo, 141-8625, Japan
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Tokyo, 142-8666, Japan
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Tokyo, 160-8582, Japan
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Tokyo, 162-8655, Japan
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Tokyo, 173-8606, Japan
GSK Investigational Site

Tokyo, 187-8510, Japan
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Tokyo, 190-0014, Japan
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Tokyo, 204-8585, Japan
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Toyama, 930-8550, Japan
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Wakayama, 640-8558, Japan
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Arnhem, 6815 AD, Netherlands
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Breda, 4818 CK, Netherlands
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Deventer, 7416 SE, Netherlands
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Eindhoven, 5623 EJ, Netherlands
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Enschede, 7513 ER, Netherlands
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Harderwijk, 3844 DG, Netherlands
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Leeuwarden, 8934 AD, Netherlands
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Nijmegen, 6532 SZ, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Zwolle, 8025 AB, Netherlands
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Bergen, 5021, Norway
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Lrenskog, 1478, Norway
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Coimbra, 3041-801, Portugal
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Guarda, 6300-035, Portugal
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Lisbon, 1649-035, Portugal
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Matosinhos Municipality, 4464-509, Portugal
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Guaynabo, 00968, Puerto Rico
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Golnik, 4204, Slovenia
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Alcorcón, 28922, Spain
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Almería, 04009, Spain
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Badalona, 08916, Spain
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Barcelona, 08003, Spain
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Barcelona, 08017, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, 08950, Spain
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Barcelona, 8025, Spain
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Benalmádena, 29631, Spain
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Bilbao, 48013, Spain
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Granada, 18014, Spain
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Jerez de la Frontera, 11407, Spain
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La Laguna Santa Cruz, 38320, Spain
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Madrid, 28031, Spain
GSK Investigational Site

Madrid, 28040, Spain
GSK Investigational Site

Madrid, 28041, Spain
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Madrid, 28046, Spain
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Málaga, 29010, Spain
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MErida Badajoz, 06800, Spain
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Pamplona, 31008, Spain
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Pozuelo de AlarcOn Madr, 28223, Spain
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Salamanca, 37007, Spain
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Santander, 39008, Spain
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Santiago de Compostela, 15706, Spain
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Valencia, 46015, Spain
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Valencia, 46017, Spain
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Via-Real CastellOn, 12540, Spain
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Vitoria-Gasteiz, 01009, Spain
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Zaragoza, 50009, Spain
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Linköping, SE-58758, Sweden
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Lund, SE-221 85, Sweden
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Östersund, SE-831 83, Sweden
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Stockholm, SE-141 86, Sweden
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Uppsala, SE-751 85, Sweden
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Aarau, 5001, Switzerland
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Basel, 4031, Switzerland
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Liestal, 4410, Switzerland
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Sankt Gallen, 9007, Switzerland
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Banchiau Taipei, 220, Taiwan
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Changhua, 500, Taiwan
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Linkou - Taoyuan Hsien, 333, Taiwan
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Taichung, 404, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 100, Taiwan
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Belfast, BT9 7AB, United Kingdom
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Birmingham, B9 5SS, United Kingdom
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Bradford, BD9 6RJ, United Kingdom
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Bristol Avon, BS10 5NB, United Kingdom
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Cottingham, HU16 5JQ, United Kingdom
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Exeter, EX2 5DW, United Kingdom
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Glasgow, G31 2ER, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, EC1A 7BE, United Kingdom
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Newcastle upon Tyne, NE7 7DN, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Oxford, OX3 9DU, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
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Preston, PR2 9HT, United Kingdom
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Wakefield, WF1 4DG, United Kingdom
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Wishaw, ML6 0JS, United Kingdom

Conditions

Explore the condition pages connected to this study.

ASTHMA