New hope for tough pancreatic cancer: targeted drug combo tested in phase 3 trial
NCT ID NCT07409272
First seen Feb 19, 2026 · Last updated May 06, 2026 · Updated 14 times
Summary
This study tests whether adding the experimental drug setidegrasib to standard chemotherapy helps people with a specific genetic form of advanced pancreatic cancer (KRAS G12D mutation) live longer. About 614 adults whose cancer has spread and cannot be removed by surgery will receive either setidegrasib or a placebo, plus chemotherapy. The main goal is to see if the combination improves overall survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baptist MD Anderson Cancer Institute
RECRUITINGJacksonville, Florida, 32207, United States
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Crosson Cancer Institute at Providence St. Jude Medical Center in Fullerton
RECRUITINGFullerton, California, 92835, United States
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HealthPartners Cancer Center at Regions Hospital
RECRUITINGSaint Paul, Minnesota, 55101, United States
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HealthPartners Frauenshuh Cancer Center
RECRUITINGSaint Louis Park, Minnesota, 55426, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITINGNew York, New York, 10016, United States
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NYU Long Island Mineola
RECRUITINGMineola, New York, 11501, United States
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Saint Elizabeth Medical Center, Inc. DBA St. Elizabeth Health Care
RECRUITINGEdgewood, Kentucky, 41017, United States
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The University of Tokyo Hospital
RECRUITINGBunkyo-ku, Tokyo, Japan
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UVA Emily Couric Cancer Center
RECRUITINGCharlottesville, Virginia, 22903, United States
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Utah Cancer Specialists
RECRUITINGSalt Lake City, Utah, 84106, United States
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
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Virginia Mason Franciscan Health - Virginia Mason Medical Center
RECRUITINGSeattle, Washington, 98101, United States
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White Plains Hospital Center for Cancer Care - Oncology
RECRUITINGWhite Plains, New York, 10601, United States
Conditions
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