Could setanaxib boost keytruda against head and neck cancer?
NCT ID NCT05323656
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This Phase 2 trial tested whether adding setanaxib (an experimental oral drug) to the standard immunotherapy pembrolizumab (Keytruda) works better than pembrolizumab alone for people with recurrent or metastatic squamous cell carcinoma of the head and neck. 55 adults whose cancer had returned or spread and who could not have surgery took part. The main goal was to see if the combination shrinks tumors more effectively.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
setanaxib (oral tablet) and pembrolizumab (Keytruda, IV infusion)
What this could lead to
If it works, this combination could slow tumor growth or shrink tumors in people with head and neck cancer that has returned or spread.
What could go wrong
This is a small, early Phase 2 trial with only 55 people. The drug may not improve outcomes over standard pembrolizumab alone, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo - Ospedale San Paolo Polo Universitario
Milan, Milan, 20142, Italy
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Centre Hospitalier Universitaire Amiens-Picardie - Site Sud
Amiens, Picardie, 80054, France
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Centre Léon Bérard
Lyon, 69008, France
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Centre de Lutte contre le Cancer - Centre Oscar Lambret
Lille, Hauts-de-France, 59000, France
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Centrum Onkologii Im. Prof. F. Łukaszczyka w Bydgoszczy
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-792, Poland
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Complejo Hospitalario de Navarra
Pamplona, 31008, Spain
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168, Italy
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Hospital Clínic de Barcelona
Barcelona, 08036, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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Hôpital Saint-André
Bordeaux, 33000, France
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Hôpital de la Timone
Marseille, 13005, France
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Institut Régional du Cancer de Montpellier
Montpellier, 34298, France
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Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, Grand Est, 54519, France
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie-Państwowy Instytut Badawczy O. w Gliwicach
Gliwice, Silesian Voivodeship, 44-102, Poland
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Ramsay Health Clinic Belharra
Bayonne, 64100, France
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Siteman Cancer Center - North County
Florissant, Missouri, 63031, United States
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Siteman Cancer Center - St. Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - West County
Creve Coeur, Missouri, 63141, United States
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The Royal Marsden Hospital - London
London, England, SW3 6JJ, United Kingdom
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The Royal Marsden Hospital Head and Neck Unit
Sutton, England, SM5 5PT, United Kingdom
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Washington University School of Medicine Center for Advanced Medicine
St Louis, Missouri, 63110, United States