Weekly shot may help diabetics use less insulin

NCT ID NCT05514535

First seen Nov 26, 2025 · Last updated May 16, 2026 · Updated 22 times

Summary

This study tested whether a once-weekly injection of semaglutide (a diabetes drug) plus a lower dose of insulin works as well as a higher dose of insulin alone for controlling blood sugar. About 573 adults with type 2 diabetes and overweight took part. The goal was to see if the combination could maintain blood sugar control while reducing insulin needs and possibly aiding weight loss.

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Contacts and locations

Locations

  • "Laiko" General Hospital of Athens

    Athens, 11527, Greece

  • "Thermi" Private Hosital

    Thessaloniki, 57001, Greece

  • "Thermi" Private Hosital

    Thessaloniki, GR-57001, Greece

  • A.O.U. Università Studi della Campania "Luigi Vanvitelli"

    Naples, Campania, 80138, Italy

  • A.O.U. Università Studi della Campania "Luigi Vanvitelli"

    Naples, 80138, Italy

  • ABS La Roca del Vallés

    La Roca Del Vallés, 08430, Spain

  • ABS La Roca del Vallés_Endocrinología

    La Roca Del Vallés, 08430, Spain

  • AHEPA General University Hospital

    Thessaloniki, 54636, Greece

  • AMC Community Endocrinology

    Albany, New York, 12203, United States

  • AMR New Orleans

    New Orleans, Louisiana, 70119, United States

  • ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari

    Montichiari, 25018, Italy

  • Academy of Diabetes, T&E

    El Paso, Texas, 79935, United States

  • Accellacare US Inc., d/b/a Accellacare of Knoxville

    Knoxville, Tennessee, 37938, United States

  • Advanced Med Res Maumee

    Maumee, Ohio, 43537, United States

  • Advanced Research Institute

    Ogden, Utah, 84405, United States

  • Albert J Weisbrot

    Mason, Ohio, 45040, United States

  • Alexandra General Hospital, Therapeutic Clinic

    Athens, 11528, Greece

  • Alexandra General Hospital, Therapeutic Clinic

    Athens, GR-11528, Greece

  • Amarillo Med Spec LLP

    Amarillo, Texas, 79106, United States

  • Amb. Diabetologie a prouch latkovej premeny a vyzivy ENDIANT s.r.o.

    Sereď, 926 01, Slovakia

  • Amherst Family Practice P.C.

    Winchester, Virginia, 22601, United States

  • Arcturus HC PLC Troy Med Res

    Troy, Michigan, 48098, United States

  • Arlington Family Res. Ctr Inc

    Arlington, Texas, 76012-4637, United States

  • Arthritis And Diabetes Clinic, Inc.

    Monroe, Louisiana, 71203, United States

  • Ascada Research

    Fullerton, California, 92835, United States

  • Azienda Ospedaliera Papa Giovanni XXIII

    Bergamo, 24127, Italy

  • Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia

    Perugia, Umbria, 06129, Italy

  • Azienda Unita' Sanitaria Locale Toscana Nord Ovest - Cittadella della Salute Campo di Marte

    Lucca, LU, 55100, Italy

  • BENROD s.r.o.

    Štúrovo, 943 01, Slovakia

  • Brengle Family Medicine

    Indianapolis, Indiana, 46260, United States

  • Briggs Clinical Research, LLC

    San Antonio, Texas, 78224, United States

  • Brigham & Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CMI Dr Pop Lavinia

    Baia Mare, Maramureş, 430222, Romania

  • CVS Store Number: 01396

    Reston, Virginia, 20191-4327, United States

  • CVS Store Number: 05520

    Savannah, Georgia, 31405-6901, United States

  • CVS Store Number: 1537

    Richmond, Virginia, 23230-3005, United States

  • CVS Store Number: 7689

    Atlanta, Georgia, 30329-4015, United States

  • Care-Partners-Clinical-Research, LLC

    Jacksonville, Florida, 32277, United States

  • Caribbean Medical Research Center

    San Juan, 00918, Puerto Rico

  • Carolina Health Specialists

    Myrtle Beach, South Carolina, 29572, United States

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • Cedar-Crosse Research Center

    Chicago, Illinois, 60607, United States

  • Central Texas Clinical Research

    Austin, Texas, 78705, United States

  • Centre for Diabetes

    Johannesburg, Gauteng, 2198, South Africa

  • Centricity Rsrch MHCity Multi

    Morehead City, North Carolina, 28557, United States

  • Centro Periférico de Especialidades Bola Azul

    Almería, 04009, Spain

  • Centrul Medical Sfantul Stefan

    Timișoara, Timiș County, 300125, Romania

  • Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed

    Brasov, 500283, Romania

  • Chase Medical Research LLC

    Waterbury, Connecticut, 06708, United States

  • Chattanooga Medical Research, LLC

    Chattanooga, Tennessee, 37404, United States

  • Chrysalis Clinical Research

    St. George, Utah, 84790, United States

  • Clinic of Diabetes Constanta

    Constanța, 900591, Romania

  • Clinica Grivitei 224 S.R.L.

    Brăila, 810197, Romania

  • Clinica Korall S.R.L. Satu Mare

    Satu Mare, 440055, Romania

  • Clinical Emergency Sf. Apostol Andrei Hospital

    Galati, 800578, Romania

  • Clinical Investigations Of Texas

    Plano, Texas, 75075, United States

  • Clinical Neuroscience Solutions

    Memphis, Tennessee, 38119, United States

  • Clinical Research Advantage, Inc./Skyline Medical Center, PC

    Elkhorn, Nebraska, 68022, United States

  • Clinical Research Trials of Florida

    Tampa, Florida, 33607, United States

  • Coastal Heritage Clinical Research

    Hinesville, Georgia, 31313, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Cotton O'Neil Diab & Endo Ctr

    Topeka, Kansas, 66606, United States

  • DCOL Ctr for Clin Res

    Longview, Texas, 75605, United States

  • DIA - CLARUS s.r.o.

    Bojnice, 97201, Slovakia

  • DIA - SANTMART, s.r.o., Ambulancia diabetologie a poruch latkovej premeny a vyzivy

    Martin, 036 01, Slovakia

  • DIA-MAX s.r.o.

    Levice, 93401, Slovakia

  • DIALIPID, s.r.o.

    Prešov, 080 01, Slovakia

  • Dentosim Queen Srl

    Târgu Mureş, 540098, Romania

  • Diab & Endo Assoc of Stark Co

    Canton, Ohio, 44718, United States

  • Diabet2 s.r.o.

    Prague, 110 00, Czechia

  • Diabetes Care Centre & CDE Centre

    Benoni, Gauteng, 1501, South Africa

  • Diabetes Glandular Diseases Clinic

    San Antonio, Texas, 78229, United States

  • Diabetes Glandular Diseases Clinic

    San Antonio, Texas, 78240, United States

  • Diabetes and Thyroid Ctr of FW

    Fort Worth, Texas, 76132, United States

  • Diabs&Nutricare Srl

    Bucharest, 040172, Romania

  • Diahelp - diabetologie

    Pardubice, 530 02, Czechia

  • Diakom, spol. s r.o.

    Poprad, 05801, Slovakia

  • Diverse Clinical Research Miami

    Miami, Florida, 33175, United States

  • Downtown LA Res Ctr. Inc.

    Los Angeles, California, 90017, United States

  • Dr J Reddy

    Durban, KwaZulu-Natal, 4450, South Africa

  • Dr Pillay's Rooms

    Durban, KwaZulu-Natal, 4450, South Africa

  • Dr T Padayachee

    eMkhomazi, KwaZulu-Natal, 4170, South Africa

  • Dr. Alexander Perkelvald

    Brooklyn, New York, 11229, United States

  • EDUMED s.r.o.

    Náchod, 547 01, Czechia

  • EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

    Thessaloniki, 54645, Greece

  • East Coast Institute for Res

    Canton, Georgia, 30114, United States

  • East Coast Institute for Res

    Macon, Georgia, 31210, United States

  • East Rand Physicians

    Benoni, Gauteng, 1501, South Africa

  • East Rand Physicians

    Johannesburg, Gauteng, 1501, South Africa

  • Elite Research Center

    Miami, Florida, 33169, United States

  • Elite Research Center

    Flint, Michigan, 48532, United States

  • Encore Medical Research LLC

    Hollywood, Florida, 33024, United States

  • Endo And Metab Cons

    Rockville, Maryland, 20852, United States

  • Endocrine Research Solutions

    Roswell, Georgia, 30076, United States

  • FUNKYSTUFF s.r.o

    Nové Zámky, 940 59, Slovakia

  • First Valley Medical Group

    Lancaster, California, 93534, United States

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di scienze Mediche e Chirurgiche

    Rome, 00168, Italy

  • General Hospital of Thessaloniki "G.Papanikolaou"

    Thessaloniki, 57010, Greece

  • Geniko Nosokomeio Nikaias Peiraia Ag. Panteleimon Geniko Nosokomeio Dytikis Attikis I - Diabetes Department

    Nikaia, GR-18454, Greece

  • Geniko Nosokomeio Peiraia Tzaneio

    Piraeus, 18536, Greece

  • Gonzalez Family & Occupational Medicine

    Houston, Texas, 77029, United States

  • Grandmed SRL

    Oradea, Bihor County, 410159, Romania

  • Great Lakes Medical Research

    Westfield, New York, 14787, United States

  • H. Infanta Luisa_Endocrino y Obesidad

    Seville, 41010, Spain

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Heritage Valley Multispeciality Group Inc

    Beaver, Pennsylvania, 15009, United States

  • Hillcrest Family Health Center

    Waco, Texas, 76708, United States

  • Holston Medical Group

    Kingsport, Tennessee, 37660, United States

  • Hospital Infanta Leonor

    Madrid, 28031, Spain

  • Hospital Son Espases

    Palma de Mallorca, 07120, Spain

  • Houston Institute for Clinical Research

    Houston, Texas, 77074, United States

  • IN-DIA s.r.o.

    Lučenec, 984 01, Slovakia

  • Ileana J. Tandron, MD APMC (a private medical office)

    Slidell, Louisiana, 70461, United States

  • Indago Research & Health Center Inc.

    Hialeah, Florida, 33012, United States

  • Intend Research

    Norman, Oklahoma, 73069, United States

  • International Research Associates, LLC_Miami

    Miami, Florida, 33183, United States

  • Iowa Diab & Endo Res Center

    West Des Moines, Iowa, 50265, United States

  • Iowa Diab & Endo Res Center

    West Des Moines, Iowa, 50266, United States

  • Istituto Scientifico San Raffaele

    Milan, MI, 20132, Italy

  • JCCT- Juno NW Houston

    Houston, Texas, 77040, United States

  • Jackson Clinic

    Jackson, Tennessee, 38305, United States

  • Jacksonville Ctr For Clin Res

    Jacksonville, Florida, 32216, United States

  • John Muir Physicians Network

    Concord, California, 94520, United States

  • Joslin Diabetes Center

    Boston, Massachusetts, 02215, United States

  • Kharkiv Regional Clinical Hospital - Endocrinology department

    Kharkiv, 61058, Ukraine

  • Khmelnytskyi Regional Hospital - Endocrinology department

    Khmelnytskyi, 29000, Ukraine

  • L-MARC Research Center

    Louisville, Kentucky, 40213, United States

  • Lenzmeier Fam Med CCT Research

    Glendale, Arizona, 85308, United States

  • Lillestol Research LLC

    Fargo, North Dakota, 58104, United States

  • Loma Linda Univ Hlth Cr Endo

    Loma Linda, California, 92354, United States

  • Lynn Institute of Norman

    Norman, Oklahoma, 73069, United States

  • MEDISPEKTRUM s.r.o.

    Bratislava, 851 01, Slovakia

  • MUDr. Jitka Zemanova - diabetologie a interna, s.r.o.

    Plzen - Vychodni Predmesti, 326 00, Czechia

  • MUDr. Korecova, metabolicke centrum s.r.o.

    Trenčín, 911 01, Slovakia

  • MUDr. Michala Pelikanova

    Prague, 140 00, Czechia

  • Mariodiab Clinic SRL

    Brasov, 500101, Romania

  • Med-Olam Clinical Reseach LLC

    Sugar Land, Texas, 77479, United States

  • MedStar Hlth Res Institute

    Hyattsville, Maryland, 20782, United States

  • MediTask, s.r.o

    Bratislava, 83103, Slovakia

  • Medical Practice SRL

    Oradea, Bihor County, 410001, Romania

  • Medical Research Institute LLC

    Saint Petersburg, 196084, Russia

  • Medical centre"Elitmedservis"LLC

    Zaporizhzhia, 69037, Ukraine

  • Medinet LLC

    Saint Petersburg, 194356, Russia

  • Mercury Str Med Grp, PLLC

    Butte, Montana, 59701, United States

  • Methodist Physicians Clinic

    Fremont, Nebraska, 68025, United States

  • Mid Hudson Med Res-New Windsor

    New Windsor, New York, 12553, United States

  • Midwest Regional Health Services

    Omaha, Nebraska, 68144, United States

  • NRC Research Institute

    Los Angeles, California, 90015, United States

  • New Horizon Research Center

    Miami, Florida, 33165, United States

  • Northeast Res Inst. Inc.

    Jacksonville, Florida, 32204, United States

  • Northern Pines Hlth Ctr, PC

    Buckley, Michigan, 49620, United States

  • Novus Medical Clinica SRL

    Ploieşti, Prahova, 100018, Romania

  • Olympus Family Medicine

    Salt Lake City, Utah, 84117, United States

  • OneLife Direct Care Inc.

    Searcy, Arkansas, 72143, United States

  • Ospedale Santa Maria Goretti - UOD Diabetologia

    Latina, LT, 04100, Italy

  • Palm Research Center Inc-Vegas

    Las Vegas, Nevada, 89128, United States

  • Palmetto Clinical Research

    Summerville, South Carolina, 29485, United States

  • Physicians East Endocrinology

    Greenville, North Carolina, 27834, United States

  • Policlinico Mater Domini Università di Catanzaro

    Catanzaro, 88100, Italy

  • Policlinico Umberto I Seconda Clinica Medica

    Roma, RM, 00161, Italy

  • Preferred Primary Care Physicians, Inc.

    Uniontown, Pennsylvania, 15401, United States

  • Premier Research Inc.

    Trenton, New Jersey, 08611, United States

  • Prevea Health

    Green Bay, Wisconsin, 54303, United States

  • Protenium Clinical Research

    Hurst, Texas, 76054, United States

  • Providence Medical Foundation

    Fullerton, California, 92835, United States

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • ResTrial s.r.o.

    Prague, 18100, Czechia

  • Reyes Clinical Research, Inc

    Miami, Florida, 33175, United States

  • Richard M Kastelic MD Assoc

    Johnstown, Pennsylvania, 15905, United States

  • S.C. Dianutrilife Medica S.R.L.

    Ploieşti, 100561, Romania

  • SC Consultmed SRL

    Iași, 700547, Romania

  • SPb SBHI "Snegirev Maternity Hospital No. 6"

    Saint Petersburg, 191014, Russia

  • SPb SBHI City polyclinic #117

    Saint Petersburg, 194358, Russia

  • San Antonio Prem Int Med

    San Antonio, Texas, 78220, United States

  • San Diego Family Care_San Diego

    San Diego, California, 92111, United States

  • San Fernando Valley Hlth Inst, LLC

    Canoga Park, California, 91304, United States

  • Scripps Memorial Hospital La Jolla

    La Jolla, California, 92037, United States

  • Shoals Primary Care

    Sheffield, Alabama, 35660, United States

  • Solaris Clinical Research

    Meridian, Idaho, 83646, United States

  • Solovyev Clinical Emergency Hospital

    Yaroslavl, 150003, Russia

  • Solovyov Clinical Emergency Hospital

    Yaroslavl, 150003, Russia

  • South Broward Research LLC

    Miramar, Florida, 33027, United States

  • South Ogden Family Medicine/ CCT Research

    Ogden, Utah, 84405, United States

  • Southern New Hampshire Diabetes and Endocrinology

    Nashua, New Hampshire, 03060, United States

  • Spitalul Judetean de Urgenta Targoviste

    Targoviste, Dâmbovița County, 130083, Romania

  • StudyMetrix Research LLC

    City of Saint Peters, Missouri, 63303, United States

  • Suncoast Clin Res Port Richey

    New Port Richey, Florida, 34652, United States

  • Suncoast Clinical Research, Inc._New Port Richey

    New Port Richey, Florida, 34652, United States

  • Suncoast Research Group, LLC

    Miami, Florida, 33135, United States

  • Synexus Clinical Research US, Inc./Desert Clinical Research,

    Mesa, Arizona, 85213, United States

  • Tatratrial s.r.o.

    Rožňava, 04801, Slovakia

  • Tekton Research

    McKinney, Texas, 75069, United States

  • Ternopil Central District Hospital - Outpatient department

    Ternopil, 46001, Ukraine

  • The Research Group of Lexington LLC

    Lexington, Kentucky, 40503, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • Thyroid Endocrinology & Diabetes PA

    Dallas, Texas, 75208, United States

  • Torrance Clin Res Inst, Inc.

    Lomita, California, 90717, United States

  • ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro

    Aveiro, 3814-501, Portugal

  • ULS Da Região De Leiria E.P.E.- Hospital de Santo André

    Leiria, 2410-197, Portugal

  • ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta

    Almada, 2805-267, Portugal

  • ULS De Braga, E.P.E. - Hospital de Braga

    Braga, 4710-243, Portugal

  • ULS De Matosinhos E.P.E.- Hospital Pedro Hispano

    Senhora Da Hora, Matosinhos, Matosinhos, 4464-513, Portugal

  • ULS De Santo António, E.P.E. - Hospital de Santo António

    Porto, 4099-001, Portugal

  • ULS De São João, E.P.E. - Hospital de São João

    Porto, 4200-319, Portugal

  • ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia

    Viana do Castelo, 4904-858, Portugal

  • ULS Do Oeste E.P.E. - Unidade Caldas da Rainha

    Caldas da Rainha, 2500-176, Portugal

  • Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital Egas Moniz

    Lisbon, 1349-019, Portugal

  • Unidade Local De Saúde De São José, E.P.E. - Hospital Curry Cabral

    Lisbon, 1050-099, Portugal

  • Unity Health-Searcy Medical Center

    Searcy, Arkansas, 72143, United States

  • Univ Diab & Endo Consultants

    Chattanooga, Tennessee, 37411, United States

  • Univ of Nebraska Medical CTR

    Omaha, Nebraska, 68198-3020, United States

  • University Clin Investigators

    Tustin, California, 92780, United States

  • University Hospital of Alexandroupolis

    Alexandroupoli, 68100, Greece

  • University Hospital of Athens ATTIKON

    Athens, Attica, 12462, Greece

  • University of North Carolina Medical Center

    Chapel Hill, North Carolina, 27514, United States

  • University of Toledo Medical Center

    Toledo, Ohio, 43614, United States

  • University of Toledo_Toledo

    Toledo, Ohio, 43614, United States

  • VIP Trials

    San Antonio, Texas, 78230, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Valley Research

    Fresno, California, 93720, United States

  • Velocity Clin Res Austin

    Cedar Park, Texas, 78613, United States

  • Velocity Clin Res Cleveland

    Beachwood, Ohio, 44122, United States

  • Velocity Clin Res Los Angeles

    Los Angeles, California, 90017, United States

  • Velocity Clin Res San Diego

    La Mesa, California, 91942, United States

  • Velocity Clin Res, Denver

    Denver, Colorado, 80209, United States

  • Velocity Clin Res, Norfolk

    Norfolk, Nebraska, 68701, United States

  • Velocity Clin Res-Chula Vista

    Chula Vista, California, 91911, United States

  • Velocity Clin Res-Salt Lk City

    West Jordan, Utah, 84088, United States

  • Velocity Clin Res_Cincinnati

    Cincinnati, Ohio, 45219, United States

  • Velocity Clinical Res Medford

    Medford, Oregon, 97504, United States

  • Velocity Clinical Res-Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research Huntington Park

    Huntington Park, California, 90255, United States

  • Virginia Endo Res, LLC

    Chesapeake, Virginia, 23321, United States

  • Volosevich First City Clinical Hospital

    Arkhangelsk, 163001, Russia

  • WVU Medicine

    Morgantown, West Virginia, 26506, United States

  • WellNow Urgent Care

    Chicago, Illinois, 60661, United States

  • West Broadway Clinic

    Council Bluffs, Iowa, 51501, United States

  • Wetlin Research Associates, Inc.

    San Diego, California, 92120, United States

  • York Clinical Research LLC

    Norfolk, Virginia, 23504, United States

Conditions

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