New drug for rare nerve tumors under safety watch in kids

NCT ID NCT05388370

First seen Mar 16, 2026 · Last updated May 14, 2026 · Updated 8 times

Summary

This study tracks the safety of selumetinib, a drug for children with neurofibromatosis type 1 (NF1) who have painful, inoperable nerve tumors. About 124 children aged 3 to 18 across Europe and Israel will be monitored for side effects like heart changes, bone growth issues, muscle problems, liver stress, eye trouble, and delayed puberty. The goal is to better understand real-world risks of this medication.

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Contacts and locations

Locations

  • Research Site

    Vienna, Austria

  • Research Site

    Amiens, France

  • Research Site

    Angers, France

  • Research Site

    Bordeaux, France

  • Research Site

    Lille, France

  • Research Site

    Lyon, France

  • Research Site

    Marseille, France

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    Paris, France

  • Research Site

    Rennes, France

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    Strasbourg, France

  • Research Site

    Toulouse, France

  • Research Site

    Tours, France

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    Vandœuvre-lès-Nancy, France

  • Research Site

    Villejuif, France

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    Dresden, Germany

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    Duisburg, Germany

  • Research Site

    Hamburg, Germany

  • Research Site

    Hanover, Germany

  • Research Site

    München, Germany

  • Research Site

    Tübingen, Germany

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    Petah Tikva, Israel

  • Research Site

    Ramat Gan, Israel

  • Research Site

    Tel Aviv, Israel

  • Research Site

    Florence, Italy

  • Research Site

    Genova, Italy

  • Research Site

    Milan, Italy

  • Research Site

    Padova, Italy

  • Research Site

    Pavia, Italy

  • Research Site

    Roma, Italy

  • Research Site

    Torino, Italy

  • Research Site

    Trieste, Italy

  • Research Site

    Rotterdam, Netherlands

  • Research Site

    Lisbon, Portugal

  • Research Site

    Porto, Portugal

  • Research Site

    Barcelona, Spain

  • Research Site

    Madrid, Spain

  • Research Site

    Málaga, Spain

  • Research Site

    Santiago de Compostela, Spain

  • Research Site

    Seville, Spain

  • Research Site

    Basel, Switzerland

  • Research Site

    Bern, Switzerland

  • Research Site

    Lausanne, Switzerland

  • Research Site

    Sankt Gallen, Switzerland

  • Research Site

    London, United Kingdom

  • Research Site

    Manchester, United Kingdom

  • Research Site

    Newcastle upon Tyne, United Kingdom

Conditions

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