New drug combo shows promise for rare childhood leukemia
NCT ID NCT07437170
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a drug called selinexor to standard chemotherapy can help children with a specific, high-risk form of acute myeloid leukemia (NUP98-positive AML). Ten children will receive the combination during their first two rounds of treatment. The goal is to see if more children achieve complete remission and have no detectable cancer cells left.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Selinexor (a drug that blocks a protein helping cancer cells survive) combined with standard chemotherapy drugs (homoharringtonine, cytarabine, and G-CSF)
What this could lead to
If successful, this could offer a more effective treatment option for children with a hard-to-treat form of leukemia, potentially leading to higher remission rates and longer survival.
What could go wrong
This is a very small early-phase trial with only 10 participants, so results may not apply to all patients. Adding selinexor to chemotherapy may also increase side effects like nausea, fatigue, or low blood counts.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310000, China