Experimental Donor-Cell therapy takes aim at tough autoimmune diseases
NCT ID NCT06294236
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests a therapy called SC291, made from donor immune cells, in 7 people with severe lupus or vasculitis that hasn't improved with standard treatments. The goal is to see if it is safe and tolerable, and to get a first look at whether it can control the disease. Participants receive the cells after a short chemotherapy course to prepare their bodies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SC291 (a type of CAR T cell therapy made from donor cells)
- What this could lead to
- If it works, this could point toward a new treatment option for people with severe autoimmune diseases that haven't responded to other therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 7 participants, so safety and effectiveness are not yet proven. There may be serious side effects, and the treatment may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Emory University
Atlanta, Georgia, 30322, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Swedish Medical Center
Seattle, Washington, 98122, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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