New drug could keep High-Risk prostate cancer from spreading

NCT ID NCT06952803

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tests whether adding the drug saruparib to standard radiation and hormone therapy can delay or prevent the spread of prostate cancer in men with high-risk disease and BRCA gene mutations. About 700 participants will receive either saruparib or a placebo alongside their usual treatment. The goal is to see if the drug improves how long men live without the cancer spreading to other parts of the body.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Study contacts

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Locations

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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85741, United States
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La Jolla, California, 92037, United States
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La Jolla, California, 92093, United States
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Los Angeles, California, 90048, United States
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San Diego, California, 92123, United States
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San Luis Obispo, California, 93401, United States
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Lakewood, Colorado, 80215, United States
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Hialeah, Florida, 33016, United States
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Jacksonville, Florida, 32224, United States
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Tampa, Florida, 33612, United States
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Newnan, Georgia, 30265, United States
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Chicago, Illinois, 60611, United States
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Chicago Ridge, Illinois, 60415, United States
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Greenwood, Indiana, 46143, United States
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Jeffersonville, Indiana, 47130, United States
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Bethesda, Maryland, 20817, United States
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Towson, Maryland, 21204, United States
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Plymouth, Massachusetts, 02360, United States
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Rochester, Minnesota, 55905, United States
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Hackensack, New Jersey, 07601, United States
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Voorhees Township, New Jersey, 08043, United States
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New York, New York, 10065, United States
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Syracuse, New York, 13210, United States
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Columbus, Ohio, 43230, United States
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Springfield, Oregon, 97477, United States
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Hershey, Pennsylvania, 17033, United States
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Lancaster, Pennsylvania, 17601, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Providence, Rhode Island, 02903, United States
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Myrtle Beach, South Carolina, 29572, United States
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Nashville, Tennessee, 37209, United States
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Austin, Texas, 78705, United States
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Austin, Texas, 78745, United States
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Houston, Texas, 77074, United States
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San Antonio, Texas, 78229, United States
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Spring, Texas, 77380, United States
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Salt Lake City, Utah, 84112, United States
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Norfolk, Virginia, 23502, United States
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Roanoke, Virginia, 24014, United States
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Virginia Beach, Virginia, 23462, United States
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Seattle, Washington, 98109, United States
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CABA, 1426, Argentina
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CABA, C1113AAE, Argentina
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Ciudad de Buenos Aires, 1181, Argentina
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Ciudad de Buenos Aires, 1426, Argentina
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Ciudad de Buenos Aires, C1419AHL, Argentina
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Córdoba, 5000, Argentina
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Córdoba, X5008HHW, Argentina
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Cuidad Autónoma de Buenos Aire, C1426ANZ, Argentina
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La Plata, 1900, Argentina
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Pergamino, B2700CPM, Argentina
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Rosario, S2000KZE, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Viedma, R8500ACE, Argentina
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Kingswood, 2747, Australia
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Murdoch, 6150, Australia
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Orange, 2800, Australia
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South Brisbane, 4101, Australia
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St Leonards, 2065, Australia
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Waratah, 2298, Australia
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Woolloongabba, 4102, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Linz, 4020, Austria
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Vienna, 1020, Austria
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Vienna, 1090, Austria
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Brussels, 1070, Belgium
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Brussels, 1200, Belgium
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Jette, 1090, Belgium
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Kortrijk, 8500, Belgium
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Libramont-Chevigny, 6800, Belgium
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Roeselare, 8800, Belgium
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Wilrijk, 2610, Belgium
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Cachoeiro de Itapemirim, 29308-014, Brazil
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Curitiba, 80810-050, Brazil
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Curitiba, Brazil
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Jaú, 17210-120, Brazil
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Londrina, 86015-520, Brazil
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Pelotas, 96020-080, Brazil
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Porto Alegre, 90035-000, Brazil
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Porto Alegre, 91350200, Brazil
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Rio de Janeiro, 22.250-905, Brazil
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Rio de Janeiro, 22775-001, Brazil
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Salvador, 41950640, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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Calgary, Alberta, T2V 1P9, Canada
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Abbotsford British Columbia, British Columbia, V2S 0C2, Canada
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Vancouver, British Columbia, V5Z 4E6, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Brampton, Ontario, L6R 3J7, Canada
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London, Ontario, N6A 5A5, Canada
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Chicoutimi, Quebec, G7H 7K9, Canada
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Toronto, M4N 3M5, Canada
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Concepción, 4070196, Chile
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Temuco, 4781156, Chile
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Beijing, 100020, China
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Beijing, 100021, China
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Beijing, 100176, China
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Changchun, 130012, China
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Changsha, 410013, China
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Chongqing, 400016, China
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Guangzhou, 510060, China
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Guangzhou, 510080, China
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Guangzhou, 510180, China
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Guangzhou, 510280, China
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Hangzhou, 31000, China
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Hangzhou, 310022, China
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Jinan, 250021, China
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Jinhua, 322100, China
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Lanzhou, 730030, China
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Nanchang, 330006, China
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Ningbo, 315010, China
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Shanghai, 200025, China
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Shanghai, 20032, China
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Shenyang, 110001, China
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Shenyang, 110042, China
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Sichuan, 610041, China
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Suining, 629018, China
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Tianjin, 300201, China
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Wuhan, 430022, China
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Wuhan, 430060, China
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Wuhu, 241000, China
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Xiamen, 361003, China
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Yangzhou, 225001, China
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Zhuhai, 519099, China
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Helsinki, 00290, Finland
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Helsinki, FI-00180, Finland
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Kuopio, 70210, Finland
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Oulu, 90029, Finland
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Tampere, FI-33521, Finland
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Turku, 20520, Finland
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Angers, 49100, France
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Bordeaux, 33000, France
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Caen, 14076, France
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Clermont-Ferrand, 63011, France
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Le Mans, 72000, France
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Marseille, 13273, France
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Montpellier, 34070, France
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Montpellier, 34298, France
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Nice, 06100, France
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Nîmes, 30029, France
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Paris, 75020, France
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Paris, 75674, France
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Paris, 75970, France
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Pierre-Bénite, 69310, France
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Rennes, 35000, France
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Saint-Herblain, 44805, France
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Saint-Priest-en-Jarez, 42270, France
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Strasbourg, 67200, France
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Suresnes, 92151, France
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Tours, 37044, France
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Vandœuvre-lès-Nancy, 54511, France
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Villejuif, 94805, France
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Augsburg, 86156, Germany
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Berlin, 10117, Germany
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Braunschweig, 38126, Germany
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Cologne, 50937, Germany
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Dresden, 1307, Germany
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Duisburg, 47169, Germany
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Düsseldorf, 40226, Germany
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Essen, 45147, Germany
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Giessen, 35392, Germany
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Göttingen, 37075, Germany
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Hamburg, 20246, Germany
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Herne, 44625, Germany
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Kiel, 24105, Germany
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Lübeck, 23538, Germany
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Marburg, 35043, Germany
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Münster, 48149, Germany
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Nuremberg, 90419, Germany
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Nürtingen, 72622, Germany
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Regensburg, 93053, Germany
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Schwerin, 19049, Germany
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Trier, 54292, Germany
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Ulm, 89081, Germany
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Würzburg, 97080, Germany
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Budapest, 1082, Hungary
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Budapest, 1122, Hungary
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Budapest, H-1145, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Gyula, 5700, Hungary
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Zalaegerszeg, 8900, Hungary
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Ansārinagar, 110 029, India
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Babgalore, 560069, India
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Delhi, 110085, India
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Hyderabad, 500019, India
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Kannur, 670103, India
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Kanpur, 208005, India
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Mumbai, 400012, India
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Nagpur, 440001, India
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Varanasi, 221005, India
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Afula, 18101, Israel
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Beersheba, 8410101, Israel
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Haifa, 31096, Israel
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Jerusalem, 91031, Israel
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Jerusalem, 9112001, Israel
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Kfar Saba, 4428164, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 6423906, Israel
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Arezzo, 52100, Italy
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Bari, 70124, Italy
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Bergamo, 24125, Italy
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Bergamo, 24127, Italy
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Chieti, 66100, Italy
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Genoa, 16132, Italy
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Milan, 20132, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Palermo, 90127, Italy
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Pisa, 56126, Italy
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Roma, 00144, Italy
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Roma, 00168, Italy
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Rozzano, 20089, Italy
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Torino, 10126, Italy
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Varese, 21100, Italy
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Verona, 37134, Italy
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Bunkyō City, 113-8431, Japan
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Fukuoka, 812-8582, Japan
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Kamakura-shi, 247-8533, Japan
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Kawagoe-shi, 350-8550, Japan
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Kawasaki-shi, 216-8511, Japan
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Kisarazu-shi, 292-8535, Japan
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Kumamoto, 860-8556, Japan
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Kyoto, 606-8507, Japan
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Maebashi, 371-8511, Japan
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Miyazaki, 889-1692, Japan
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Ōta-ku, 373-8550, Japan
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Sagamihara-shi, 252-0375, Japan
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Shimotsuke-shi, 329-0498, Japan
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Yokohama, 232-0024, Japan
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Yokohama, 241-8515, Japan
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Batu Caves, 68100, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 62250, Malaysia
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Pulau Pinang, 10450, Malaysia
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Hilversum, 1213 XZ, Netherlands
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Hoofddorp, 2134 TM, Netherlands
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Maastricht, 6202 AZ, Netherlands
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Nijmegen, 6532 SZ, Netherlands
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Roosendaal, 4708 AE, Netherlands
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Lima, 15036, Peru
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Lima, LIMA 29, Peru
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Lima, Lima 34, Peru
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Trujillo, 13008, Peru
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NOT_YET_RECRUITING

Gdynia, 81-519, Poland
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Gliwice, 44-101, Poland
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Koszalin, 75-581, Poland
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Krakow, 30-727, Poland
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Piotrkow Trybunalski, 97-300, Poland
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Poznan, 61-731, Poland
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Rzeszów, 35-001, Poland
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Warsaw, 04-073, Poland
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Busan, 49241, South Korea
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Daegu, 41404, South Korea
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Goyang-si, 10408, South Korea
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Seoul, 03080, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 3722, South Korea
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Seoul, 5505, South Korea
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Barcelona, 08041, Spain
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Barcelona, 8035, Spain
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Girona, 17007, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Majadahonda, 28222, Spain
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Málaga, 29009, Spain
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Málaga, 29010, Spain
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Oviedo, 33011, Spain
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Sabadell, 08208, Spain
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Santander, 39008, Spain
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Valencia, 46009, Spain
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Valencia, 46014, Spain
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Gothenburg, 413 45, Sweden
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Malmö, 205 02, Sweden
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Stockholm, 112 81, Sweden
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Stockholm, 141 86, Sweden
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Umeå, 901 85, Sweden
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Uppsala, 75185, Sweden
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Kaohsiung City, 83301, Taiwan
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Taichung, 40705, Taiwan
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Taichung, 43503, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10055, Taiwan
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Taipei, 110, Taiwan
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Taipei, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 50200, Thailand
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Pathum Thani, 12120, Thailand
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Songkhla, 90110, Thailand
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Ankara, 06620, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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Cordaleo, 35575, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Sakarya, 54290, Turkey (Türkiye)
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Şahinbey, 27310, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Bristol, BS2 8ED, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Exeter, EX2 5DW, United Kingdom
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Glasgow, G12 0YN, United Kingdom
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Greater London, SW3 6JJ, United Kingdom
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Guildford, GU2 7XX, United Kingdom
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London, EC1M6BQ, United Kingdom
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London, NW3 2QG, United Kingdom
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London, WC1N 3BG, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Newcastle, NE7 7DN, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Preston, PR2 9HT, United Kingdom
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Romford, RM7 0AG, United Kingdom

Conditions

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