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Could weak muscles predict who gets relief from spinal injections?

NCT ID NCT07855419

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Oct 02, 2026 · Last updated Oct 08, 2026 · Updated 2 times

Summary

Researchers at Marmara University are studying whether sarcopenia, the age-related loss of muscle mass and strength, affects how well epidural steroid injections relieve pain in people with lumbar spinal stenosis. The study enrolls 70 adults aged 50 to 75 who have low back or leg pain from spinal narrowing and are scheduled for an interlaminar epidural steroid injection as part of routine care. Before the procedure, participants complete muscle assessments including a questionnaire, a handgrip test, and a sit-to-stand test, and their MRI scans are reviewed for muscle quality and stenosis severity. The team then tracks pain, function, walking ability, and quality of life at three weeks and three months to see whether sarcopenia and muscle features on MRI relate to how much relief patients get.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If muscle loss tracks with poorer pain relief, doctors could one day use simple strength tests to pick who benefits most from epidural steroid injections.
What could go wrong
This observational study follows 70 people and cannot prove cause and effect. Results may not apply to other clinics, and many factors beyond muscle mass shape how much an injection helps.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of patients aged 50-75 years with clinically and radiologically diagnosed lumbar spinal stenosis who are scheduled to undergo interlaminar epidural steroid injection as part of routine clinical care due to persistent symptoms despite conservative treatment. Participants will be classified according to sarcopenia status based on baseline assessments and followed for 3 months.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical and radiological diagnosis of lumbar spinal stenosis * Persistent symptoms despite conservative treatment and scheduled to undergo interlaminar epidural steroid injection as part of routine clinical care * Age between 50 and 75 years * Low back and/or leg pain for at least 3 months * Availability of lumbar magnetic resonance imaging (MRI) Exclusion Criteria: * History of lumbar fusion surgery * Lumbar epidural steroid injection within the previous 3 months * Prominent radiculopathy due to lumbar disc herniation * Severe motor deficit or an indication for surgical treatment * Polyneuropathy, neuromuscular disease, or neurological disease that may significantly affect muscle mass * Active malignancy or systemic inflammatory disease * Significant mobility limitation due to advanced hip or knee osteoarthritis * Cognitive impairment or communication problems that may prevent completion of study assessments * Coagulopathy or active infection constituting a contraindication to epidural injection * Inflammatory rheumatic disease requiring chronic corticosteroid therapy

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Conditions

The condition(s) this trial relates to.

lumbar spinal stenosis Sarcopenia spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sarcopenia Spinal stenosis lumbar

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Marmara University Pendik Training and Research Hospital

    RECRUITING

    Istanbul, Istanbul, 34899, Turkey (Türkiye)

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