Radiation and immunotherapy combo tested for lung cancer
NCT ID NCT03307759
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase trial tested the safety of giving a precise form of radiation (SABR) either before or after the immunotherapy drug pembrolizumab in 13 people with metastatic non-small cell lung cancer. The goal was to see if the combination caused severe side effects and whether it helped shrink tumors. The study was terminated early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pembrolizumab (immunotherapy) and stereotactic ablative body radiotherapy (SABR, a precise form of radiation)
- What this could lead to
- If successful, this could point toward a more effective way to combine radiation and immunotherapy for advanced lung cancer, potentially improving tumor shrinkage and survival.
- What could go wrong
- This is a very early (phase 1), small (13 participants) terminated trial, so results are limited and may not be reliable. The combination may cause severe side effects (grade 3 toxicities) and may not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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