Can precise radiation pause kidney Cancer's march?
NCT ID NCT02956798
First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time
Summary
This trial tests whether stereotactic ablative body radiation (SAbR), a precise form of high-dose radiation, can delay the need for systemic therapy in people with oligometastatic renal cell carcinoma, meaning kidney cancer that has spread to a few limited sites. Researchers will measure how long participants can go without starting systemic therapy, as well as progression-free survival, overall survival, and quality of life. The study enrolls adults with up to three sites of metastasis who have confirmed kidney cancer. The goal is to see if targeting those few spots with radiation can keep the cancer in check longer.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Stereotactic ablative body radiation (SAbR), a precise high-dose radiation therapy
- What this could lead to
- If it works, SAbR could help people with limited kidney cancer spread delay or avoid systemic therapy, improving quality of life and extending time without disease progression.
- What could go wrong
- This is a small, early-phase trial, so results may not apply broadly. Radiation can cause side effects, and the delay in systemic therapy may not translate into longer overall survival.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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23 people
The number who actually took part.
- Started
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Jul 2018
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Metastatic renal cell carcinoma with limited measurable extracranial metastases (Limited metastases, or oligometastases, defined as ≤3 sites of metastasis). * Radiographic evidence of metastatic disease. CT should be performed within 30 days of registration. * Pathology confirmation of Renal cell carcinoma. * Prior surgery, or radiation is permitted. * Age ≥ 18 years. * Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, and for 90 days after Radiation treatment has been completed . Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: * Has not undergone a hysterectomy or bilateral oophorectomy; or * Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months). * Ability to understand and the willingness to sign a written informed consent and agrees to undergo image studies and follow up Exclusion Criteria: * Subjects with brain metastasis as assessed by contrast MRI or contrast CT scans(contrast recommended). * Subjects with previous history of brain metastasis. * Subjects that received prior systemic therapy for kidney cancer in the past 1 year, except one line of immuno- or cytokine therapy (e.g. prior IL-2); systemic therapy for other cancers does not apply to this exclusion criteria * Subjects with ≥3 unfavorable prognostic factors defined by Motzer et al. (1999), (KPS \<80% or ECOG\>1, Hgb \< LLN, LDH \>1.5x normal, corrected serum calcium \>10mg/dl and absence of prior nephrectomy), Patients with 0, 1-2, and ≥3 factors had time to death of 20 months, 10 months and 4 months. * Subjects with life expectancy \< 6 months. * Subjects receiving any other investigational agents * Subjects must not be pregnant due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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