New hope for myelofibrosis patients: experimental drug RVU120 enters Mid-Stage trial
NCT ID NCT06397313
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This Phase 2 trial tests a new drug called RVU120, alone or with the standard drug ruxolitinib, in 230 adults with intermediate or high-risk myelofibrosis. The main goal is to see if the drug can shrink the spleen and improve symptoms. Participants must have not responded well to prior JAK inhibitor treatment or be unable to take it.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RVU120 (a CDK8/CDK19 inhibitor) and ruxolitinib (a JAK inhibitor)
What this could lead to
If successful, this could offer a new treatment option for people with myelofibrosis who have not responded well to current therapies.
What could go wrong
This is an early Phase 2 trial, so the drug may not work as hoped or could cause unexpected side effects. Results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"
RECRUITINGCatania, Italy
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Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
RECRUITINGBrescia, Italy
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Centrum Wsparcia Badań Klinicznych UCK Ośrodek Badań Klinicznych Wczesnych Faz
RECRUITINGGdansk, Poland
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Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
RECRUITINGMilan, Italy
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Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l.
RECRUITINGMeldola, Italy
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Lux Med Onkologia Sp. z o.o.
RECRUITINGWarsaw, Poland
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M2M Med. Sp. z o.o. Sp. j.
RECRUITINGChorzów, Poland
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Policlinico Sant'Orsola-Malpighi
RECRUITINGBologna, Italy
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Pratia Hematologia Sp. z o.o.
RECRUITINGKatowice, Poland
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Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie
RECRUITINGLublin, Poland
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Samodzielny Publiczny Zakład Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
RECRUITINGKrakow, Poland
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Szpital Uniwersytecki Imienia Karola Marcinkowskiego w Zielonej Gorze Sp. z o. o.
COMPLETEDZielona Góra, Poland
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Szpital Uniwersytecki nr 2 im. dr Jana Biziela
RECRUITINGBydgoszcz, Poland
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Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
RECRUITINGWroclaw, Poland
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Wojewódzki Szpital Specjalistyczny w Białej Podlaskiej
RECRUITINGBiała Podlaska, Poland
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Wojewódzki Szpital Zespolony im. L. Rydygiera w Toruniu
RECRUITINGTorun, Poland
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Wojskowy Instytut Medyczny Państwowy Instytut Badawczy
RECRUITINGWarsaw, Poland
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Świętokrzyskie Centrum Onkologii Samodzielny Publiczny Zakład Opieki Zdrowotnej
COMPLETEDKielce, Poland