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Magnetic brain zaps could lift depression in seniors without pills

NCT ID NCT04842929

Completed Symptom relief Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a gentle magnetic brain stimulation technique, called rTMS with theta-burst stimulation, can help treat depression in people over 60. Over 100 participants received either real or sham stimulation daily for about 4 weeks. The goal was to see if this non-drug approach could safely reduce depressive symptoms without the side effects of medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) using theta-burst stimulation (TBS)
What this could lead to
If it works, this could offer a drug-free option to ease depression in older adults, avoiding side effects and drug interactions.
What could go wrong
This is a completed early-stage trial with only 108 participants, so results may not apply to everyone. The sham control means the real benefit might be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • University of Sao Paulo

    São Paulo, São Paulo, Brazil

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