A dead Probiotic's ghost may help tame weight gain
NCT ID NCT07788833
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests whether a daily supplement called RSB11-HI, a heat-inactivated postbiotic, can support weight management and metabolic wellness in healthy adults. Over 8 weeks, 120 participants will take either the supplement or a placebo, with researchers tracking changes in body weight, BMI, waist circumference, and appetite. The study also looks at whether effects differ among general healthy, perimenopausal, and mild inflammation groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- RSB11-HI, a heat-inactivated postbiotic derived from Lactiplantibacillus plantarum RSB11, taken orally once daily for 8 weeks
- What this could lead to
- If it works, this could point toward a simple daily supplement that helps healthy adults manage weight and support metabolic wellness without changing their diet or exercise habits.
- What could go wrong
- This is an early, small trial with 120 participants, so results may not apply to everyone. The supplement may have no effect on weight or metabolism, and any benefits could be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female, 18 to 55 years of age. * Body Mass Index (BMI) between 23 and 32 kg/m² at screening. * Able and willing to provide electronic informed consent. * Willing and able to comply with all study procedures and scheduled assessments. * Willing to maintain usual dietary habits and physical activity throughout the study period. * Access to a smartphone, tablet, or computer with reliable internet connectivity to complete remote study assessments. * Willing to refrain from initiating new dietary supplements, structured weight management programs, or significant lifestyle modifications intended to influence study outcomes during study participation. Exclusion Criteria: * Participation in another interventional clinical study within 30 days prior to screening. * Current use of prescription medications intended for weight management. * Current use of probiotic or postbiotic supplements that cannot be discontinued at least 4 weeks prior to enrollment. * Antibiotic use within 4 weeks prior to screening. * Pregnancy, planned pregnancy during the study period, or breastfeeding. * Known allergy or hypersensitivity to any component of the investigational product or placebo. * History of any gastrointestinal condition, metabolic disorder, or other clinically significant medical condition that, in the opinion of the investigator, could interfere with study participation or interpretation of study results. * Any physical, psychological, or behavioral condition that, in the opinion of the investigator, would make participation unsafe or compromise compliance with the study protocol.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Able Biolabs LLC
RECRUITINGDallas, Texas, 75247, United States
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