New pill could ease painful skin lumps for those failed by antibiotics

NCT ID NCT07228390

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests a daily pill called ritlecitinib for adults with moderate to severe hidradenitis suppurativa (HS), a condition causing painful red skin lumps. About 240 participants who haven't been helped by antibiotics will be randomly assigned to get the drug or a placebo for 16 weeks. Researchers will compare how many people see at least a 50% reduction in their HS symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ritlecitinib (a daily oral pill)
What this could lead to: If it works, this could point toward a new treatment option for people with moderate to severe hidradenitis suppurativa who haven't been helped by antibiotics.
What could go wrong: This is an early Phase 2 trial with only 240 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hidradenitis suppurativa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIDRADENITIS SUPPURATIVA

Contacts and locations

Locations

Advanced Medical Research, PC.
RECRUITING

Sandy Springs, Georgia, 30328, United States
Alliance Clinical Research of Tampa
RECRUITING

Tampa, Florida, 33615, United States
Athens Medical Center - Psychikon branch
RECRUITING

Athens, Attica, 11525, Greece
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Burke Pharmaceutical Research
RECRUITING

Hot Springs, Arkansas, 71913, United States
CHOP-Centro De Especialidades De Mollabao
RECRUITING

Pontevedra, 36001, Spain
CaRe Clinic
RECRUITING

Red Deer, Alberta, T4P 1K4, Canada
Carbon Health - Urgent Care - La Habra
RECRUITING

La Habra, California, 90631, United States
Center for Clinical Studies, LTD. LLP
RECRUITING

Houston, Texas, 77004, United States
Centre de Recherche Saint-Louis inc.
RECRUITING

Québec, G1W 4R4, Canada
Centrum Zdrowia Dziecka i Rodziny im Jana Pawla II w Sosnowcu
RECRUITING

Sosnowiec, 41-200, Poland
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-566, Poland
ClinOhio Research Services
RECRUITING

Columbus, Ohio, 43213, United States
Columbia Dermatology & Aesthetics
RECRUITING

Columbia, South Carolina, 29212, United States
Community Imaging Center
RECRUITING

Indianapolis, Indiana, 46256, United States
D&H Tamarac Research Center
RECRUITING

Tamarac, Florida, 33321, United States
DAR Clinical Research
RECRUITING

Ottawa, Ontario, K1V 1C1, Canada
DJL Clinical Research, PLLC
RECRUITING

Charlotte, North Carolina, 28211, United States
DS Research of Kentucky
RECRUITING

Louisville, Kentucky, 40241, United States
Dawes Fretzin Clinical Research Group, LLC
RECRUITING

Indianapolis, Indiana, 46250, United States
Dermatological and Venereological Hospital Andreas Syggros
RECRUITING

Athens, 161 21, Greece
Dermatology Research Institute
RECRUITING

Calgary, Alberta, T2J 7E1, Canada
Dermedic Jacek Zdybski
RECRUITING

Ostrowiec Świętokrzyski, 27-400, Poland
Endeavor Health
RECRUITING

Skokie, Illinois, 60077, United States
Essential Medical Research - Overland Park
RECRUITING

Overland Park, Kansas, 66213, United States
Eurofins CRL
RECRUITING

Forest, Virginia, 24551, United States
FACET Dermatology
RECRUITING

Toronto, Ontario, M4E 1R7, Canada
First OC Dermatology Research Inc
RECRUITING

Fountain Valley, California, 92708, United States
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital Universitario Puerta del Mar
RECRUITING

Cadiz, 11009, Spain
Hospital Universitario Virgen Nieves
RECRUITING

Granada, 18012, Spain
Hospital de Manises
RECRUITING

Manises, Valencia, 46940, Spain
Integrative Skin Science and Research
RECRUITING

Sacramento, California, 95815, United States
Klinika Ambroziak Dermatologia
RECRUITING

Warsaw, 02-953, Poland
Laser Rejuvenation Clinics Edmonton D.T. Inc
RECRUITING

Edmonton, Alberta, T5J 3S9, Canada
Mayo Clinic
NOT_YET_RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic Hospital
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Specialty Building
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Medical Dermatology Specialists
RECRUITING

Phoenix, Arizona, 85006, United States
NMC Research LLC
RECRUITING

Tampa, Florida, 33607, United States
North York Research Inc
RECRUITING

Toronto, Ontario, M2N 3A6, Canada
Northridge Clinical Trials
RECRUITING

Northridge, California, 91325, United States
Olympian Clinical Research
RECRUITING

Largo, Florida, 33770, United States
Olympian Clinical Research
RECRUITING

Tampa, Florida, 33615, United States
Options Research Group
RECRUITING

West Lafayette, Indiana, 47906, United States
Palmetto Clinical Trial Services - Greenville
RECRUITING

Greenville, South Carolina, 29615, United States
Papageorgiou General Hospital of Thessaloniki
RECRUITING

Thessaloniki, Thessaloníki, 564 29, Greece
Państwowy Instytut Medyczny MSWiA
RECRUITING

Warsaw, 02-507, Poland
Penta Hospitals Badania Kliniczne sp. z o.o.
RECRUITING

Gdansk, 80-546, Poland
Revival Research Institute, LLC
RECRUITING

Southfield, Michigan, 48034, United States
Royalderm Agnieszka Nawrocka
RECRUITING

Warsaw, 02-962, Poland
Ryan Clinical Research Inc.
RECRUITING

Newmarket, Ontario, L3Y 5G8, Canada
Skin Care Research
RECRUITING

Boca Raton, Florida, 33486, United States
Skin Physicians Dermatology
RECRUITING

Edmonton, Alberta, T6W 4V4, Canada
Skin Specialists, PC dba Schlessinger MD
RECRUITING

Omaha, Nebraska, 68144, United States
Skin and Hair Center
RECRUITING

Overland Park, Kansas, 66213, United States
Soft Skin Medical Center Dr Elzbieta Wojtowicz-Prus
RECRUITING

Wroclaw, 50-551, Poland
Stracskin
RECRUITING

Portsmouth, New Hampshire, 03801, United States
The Indiana Clinical Trials Center, PC
RECRUITING

Plainfield, Indiana, 46168, United States
Trialmed CRS - Warszawa
RECRUITING

Warsaw, 02-482, Poland
TruDerm & TruSpa
RECRUITING

Wellington, Florida, 33449, United States
Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.
RECRUITING

Szczecin, 71-500, Poland
USF - Carol and Frank Morsani Center for Advanced Healthcare-Clinical Research Center
RECRUITING

Tampa, Florida, 33612, United States
USF Florida Hearing Clinic
RECRUITING

Tampa, Florida, 33620, United States
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
RECRUITING

Dresden, Saxony, 01307, Germany
University General Hospital of Larissa
RECRUITING

Larissa, Thessalía, 411 10, Greece
Universitätsklinikum Frankfurt
RECRUITING

Frankfurt, 60590, Germany
Universitätsklinikum Schleswig Holstein - Campus Lübeck
RECRUITING

Lübeck, 23538, Germany
Whisper Hearing Center
RECRUITING

Indianapolis, Indiana, 46240, United States
Wolverine Clinical Trials
RECRUITING

Santa Ana, California, 92706, United States
Ziaderm Research LLC
RECRUITING

North Miami Beach, Florida, 33162, United States

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