New hope for rare stomach cancer: drug combo targets tough mutations
NCT ID NCT05734105
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two drugs, ripretinib and sunitinib, in people with advanced gastrointestinal stromal tumors (GIST) that have specific genetic changes (KIT exon 11 plus 17/18 mutations) and have stopped responding to the first treatment, imatinib. About 54 participants will be randomly assigned to receive either ripretinib or sunitinib to see which one better delays cancer growth. If the cancer worsens on sunitinib, those patients may switch to ripretinib.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ripretinib (QINLOCK) and Sunitinib (Sutent)
- What this could lead to
- If ripretinib works better than sunitinib, it could become a new standard second-line treatment for people with this specific type of advanced GIST.
- What could go wrong
- This is a relatively small Phase 3 trial (54 participants) and results may not apply to all GIST patients. There is no guarantee ripretinib will prove superior or be approved for this use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AC Camargo Câncer Center
São Paulo, São Paulo, 01509-900, Brazil
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Alfred Health
Melbourne, Victoria, 3004, Australia
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Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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Asan Medical Center
Seoul, 05505, South Korea
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Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi
Bologna, 40138, Italy
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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CEPEN - Centro de Pesquisa e Ensino em Saude de Santa Catarina
Florianópolis, Santa Catarina, 88034-000, Brazil
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CHU Dijon
Dijon, Bourgogone, 21079, France
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Centre Eugène Marquis
Rennes, Ille et Vilaine, 35000, France
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Centre Léon Bérard
Lyon, 69373, France
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Centro de Oncología de Precisión
Santiago, RM, 7550000, Chile
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China Medical University Hospital
Taichung, 40447, Taiwan
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clínica San Carlos De Apoquindo Red Salud UC Christus
Las Condes, RM, 7620002, Chile
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Complejo Hospitalario Universitario de Vigo - Hospital Alvaro Cunqueiro
Vigo, Pontevedra, 36312, Spain
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Heidelberg University Hospital
Heidelberg, 69120, Germany
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Helios Klinikum Berlin-Buch
Berlin, Germany
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Hospital 9 de Julho
São Paulo, São Paulo, 01409-002, Brazil
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital Sirio-Libanes
São Paulo, São Paulo, 01308, Brazil
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Hospital Universitario Centra de Asturias
Oviedo, 33011, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, Barcelona, 08035, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital de Cancer de Barretos - Fundacao Pio XII
Barretos, São Paulo, 14748-400, Brazil
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Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
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INCA - Instituto Nacional de Cancer
Rio de Janeiro, Rio de Janeiro, 20231, Brazil
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IRCCS Istituto Clinico Humanitas
Rozzano, 20089, Italy
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Institut Bergonié
Bordeaux, 33076, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Instituto Valenciano de Oncologia - IVO
Valencia, Valencia, 46009, Spain
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Istituto Nazionale Tumori IRCCS Fondazione "G Pascale"
Naples, Napoli, 80131, Italy
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Istituto Oncologico Veneto-IOV IRCCS
Padova, 35128, Italy
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Juravinski Cancer Centre
Hamilton, Ontario, L8V 5C2, Canada
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LUMC
Leiden, 2333 ZA, Netherlands
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M Health Fairview University of Minnesota Medical Center
Minneapolis, Minnesota, 55455, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
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McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Narodowy Instytut Onkologii Im . Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, Warszawa, 02-781, Poland
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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Northwell Health Cancer Institute/ R.J. Zuckerberg Cancer Center
New York, New York, 11042, United States
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OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Oslo University Hospital
Oslo, Norway, 0379, Norway
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Prince of Wales Hospital
Randwick, New South Wales, 2031, Australia
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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St. James University Hospital
Leeds, West Yorkshire, LS9 7TF, United Kingdom
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Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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The Royal Marsden Hospital NHS Foundation Trust
London, Greater London, SW3 6JJ, United Kingdom
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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U.O.C. Oncologia Medica
Palermo, Palermo, 90127, Italy
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UMC Groningen
Groningen, 9713, Netherlands
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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Universitares Krebszentrum Leipzig
Leipzig, 04103, Germany
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University Health Network, Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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University Hospital Essen (Universitätsklinikum Essen)
Essen, 45147, Germany
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University of Virginia
Charlottesville, Virginia, 22908, United States
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Università Campus Bio-Medico di Roma
Roma, 00128, Italy
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Yale University
New Haven, Connecticut, 06520, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- One dose may not fit all: blood tests could tailor cancer drug dosing
- Can a Brain-Cancer drug take on a stubborn stomach tumor?
- Can a targeted pill shrink a rare, Treatment-Resistant stomach cancer?
- Massive GIST registry aims to unlock secrets of rare cancer
- New hope for stomach cancer patients Who've tried everything?
- New hope for GIST: experimental combo targets hard-to-treat tumors