New pill aims to cut sickle cell pain attacks in half
NCT ID NCT06975865
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether the oral drug rilzabrutinib can lower the number of painful vaso-occlusive crises in people with sickle cell disease. About 192 participants aged 10 to 65 will receive either the drug or a placebo for 52 weeks. The main goal is to see if the drug reduces crisis rates compared to placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rilzabrutinib (an oral tablet)
What this could lead to
If it works, this could provide a new daily pill to reduce painful sickle cell crises and related complications.
What could go wrong
This is a Phase 3 trial, but results are not yet known. The drug may not reduce crises more than placebo, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello-Site Number : 3800002
RECRUITINGPalermo, 90146, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Azienda Ospedaliera Universitaria San Luigi Gonzaga, SSD Microcitemie Malattie Rare Ematologiche-Site Number : 3800007
RECRUITINGOrbassano, Torino, 10043, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Azienda Ospedaliera Universitaria, Università della Campania "Luigi Vanvitelli" Napoli-Site Number : 3800005
RECRUITINGNaples, Napoli, 80138, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Azienda Ospedaliero Universitaria Careggi SOD Ematologia-Site Number : 3800006
RECRUITINGFlorence, Firenze, 50134, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Baylor College of Medicine- Site Number : 8400055
RECRUITINGHouston, Texas, 77030, United States
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Centro Ricerche Cliniche Verona s.r.l. presso Ospedale G.B. Rossi Borgo Roma-Site Number : 3800003
RECRUITINGVerona, 37134, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Fundação Faculdade Regional de Medicina de São José do Rio Preto- Site Number : 0760001
RECRUITINGSão José do Rio Preto, São Paulo, 15090-000, Brazil
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Hospital Samaritano De Sao Paulo- Site Number : 0760005
RECRUITINGSão Paulo, 01232-010, Brazil
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Hospital Santa Izabel- Site Number : 0760006
RECRUITINGSalvador, Estado de Bahia, 40050-410, Brazil
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IRCCS Ospedale Pediatrico Bambino Gesù-Site Number : 3800001
RECRUITINGRome, Roma, 00165, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Indiana University Health Riley Hospital for Children- Site Number : 8400056
RECRUITINGIndianapolis, Indiana, 46202, United States
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Investigational Site Number : 0560001
RECRUITINGLeuven, 3000, Belgium
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Investigational Site Number : 0560002
RECRUITINGBrussels, 1070, Belgium
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Investigational Site Number : 0560003
RECRUITINGBrussels, 1020, Belgium
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Investigational Site Number : 2500001
RECRUITINGParis, 75015, France
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Investigational Site Number : 2500002
RECRUITINGCréteil, 94010, France
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Investigational Site Number : 2500004
RECRUITINGToulouse, 31100, France
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Investigational Site Number : 2500005
RECRUITINGMarseille, 13885, France
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Investigational Site Number : 2760002
RECRUITINGEssen, 45147, Germany
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Investigational Site Number : 2760004
RECRUITINGStuttgart, 70736, Germany
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Investigational Site Number : 3000001
RECRUITINGAthens, 115 27, Greece
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Investigational Site Number : 3000002
RECRUITINGPátrai, 265 04, Greece
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Investigational Site Number : 3000003
RECRUITINGAthens, 115 27, Greece
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Investigational Site Number : 3760001
RECRUITINGAfula, 1834111, Israel
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Investigational Site Number : 3760002
RECRUITINGAfula, 1834111, Israel
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Investigational Site Number : 3760005
RECRUITINGHaifa, 3109601, Israel
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Investigational Site Number : 3760006
RECRUITINGHaifa, 3109601, Israel
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Investigational Site Number : 3800004
RECRUITINGMilan, Milano, 20122, Italy
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Investigational Site Number : 5120001
RECRUITINGMuscat, 123, Oman
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Investigational Site Number : 5280002
RECRUITINGRotterdam, 3015 CE, Netherlands
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Investigational Site Number : 7240001
RECRUITINGMadrid, 28046, Spain
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Investigational Site Number : 7240002
RECRUITINGMadrid, 28007, Spain
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Investigational Site Number : 7920001
RECRUITINGAdana, 01330, Turkey (Türkiye)
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Investigational Site Number : 7920002
RECRUITINGAdana, 01330, Turkey (Türkiye)
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Investigational Site Number : 7920003
RECRUITINGMersin, 33330, Turkey (Türkiye)
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Investigational Site Number : 8260001
RECRUITINGLondon, London, City of, SE5 9RL, United Kingdom
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Investigational Site Number : 8260002
RECRUITINGLondon, Harrow, NW10 7NS, United Kingdom
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Louisiana State University Health Sciences Center - Shreveport- Site Number : 8400037
RECRUITINGShreveport, Louisiana, 71130, United States
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Montefiore Medical Center - Moses Campus- Site Number : 8400057
RECRUITINGThe Bronx, New York, 10467, United States
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Oncology & Hematology Associates of West Broward- Site Number : 8400029
RECRUITINGCoral Springs, Florida, 33065, United States
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Phoenix Children's Hospital- Site Number : 8400028
RECRUITINGPhoenix, Arizona, 85016, United States
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Pontifícia Universidade Católica do Rio de Janeiro- Site Number : 0760009
RECRUITINGRio de Janeiro, 22451-900, Brazil
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Prisma Health- Site Number : 8400051
RECRUITINGGreenville, South Carolina, 29605, United States
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Richmond University Medical Center- Site Number : 8400038
RECRUITINGStaten Island, New York, 10310, United States
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Southern Specialty Research- Site Number : 8400059
RECRUITINGFlowood, Mississippi, 39232, United States
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Sylvester Comprehensive Cancer Center- Site Number : 8400020
RECRUITINGMiami, Florida, 33136, United States
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Universidade Federal de Goias- Site Number : 0760002
RECRUITINGGoiânia, Goiás, 74605-020, Brazil
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University of Alabama at Birmingham- Site Number : 8400003
RECRUITINGBirmingham, Alabama, 35233, United States
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University of California San Francisco- Site Number : 8400040
RECRUITINGFresno, California, 93701, United States
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University of Illinois-Chicago - College of Medicine- Site Number : 8400054
RECRUITINGChicago, Illinois, 60612, United States
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University of Maryland School of Medicine - Baltimore- Site Number : 8400041
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Michigan Health System - Ann Arbor- Site Number : 8400035
RECRUITINGAnn Arbor, Michigan, 48109, United States
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VCU Massey Cancer Center: Dalton Oncology Clinic- Site Number : 8400012
RECRUITINGRichmond, Virginia, 23298, United States