Common antibiotic could tame rare calcium disorder
NCT ID NCT03301038
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the antibiotic rifampin can safely lower high calcium levels in the blood and urine of people with a rare genetic mutation in the CYP24A1 gene. The condition can cause kidney stones and other problems. Sixty participants aged 6 months to 65 years will take rifampin for 16 weeks, with regular monitoring of calcium and related markers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rifampin (an antibiotic)
- What this could lead to
- If it works, this could offer a way to manage dangerously high calcium levels in people with this rare genetic condition, reducing kidney damage and other complications.
- What could go wrong
- This is a small, early-phase trial with only 60 people. Rifampin may not lower calcium enough, or side effects like liver issues or allergic reactions could limit its use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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