New hope for babies with aggressive leukemia: targeted drug trial underway

NCT ID NCT05761171

Ongoing Disease control Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a new oral drug called revumenib to standard chemotherapy is safe and effective for infants and young children with a specific, high-risk type of leukemia that has come back or hasn't responded to previous treatments. The trial aims to find the best dose and see if the combination can help clear the cancer from the body. It is for children under 6 years old whose leukemia cells have a specific genetic change called a KMT2A rearrangement.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AdventHealth Orlando

Orlando, Florida, 32803, United States
Albany Medical Center

Albany, New York, 12208, United States
Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591, United States
Arnold Palmer Hospital for Children

Orlando, Florida, 32806, United States
BI-LO Charities Children's Cancer Center

Greenville, South Carolina, 29605, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4, Canada
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec, G1V 4G2, Canada
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, 30329, United States
Children's Hospital

London, Ontario, N6A 5W9, Canada
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Medical Center of Akron

Akron, Ohio, 44308, United States
Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114, United States
Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States
Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1, Canada
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of San Antonio

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507, United States
Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dayton Children's Hospital

Dayton, Ohio, 45404, United States
Dell Children's Medical Center of Central Texas

Austin, Texas, 78723, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
IWK Health Centre

Halifax, Nova Scotia, B3K 6R8, Canada
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kaiser Permanente Downey Medical Center

Downey, California, 90242, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Legacy Emanuel Children's Hospital

Portland, Oregon, 97227, United States
Loma Linda University Medical Center

Loma Linda, California, 92354, United States
Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Ontario, L8N 3Z5, Canada
Medical City Dallas Hospital

Dallas, Texas, 75230, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Nemours Children's Hospital

Orlando, Florida, 32827, United States
Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Prisma Health Richland Hospital

Columbia, South Carolina, 29203, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903, United States
Saint Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134, United States
Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607, United States
Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203, United States
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

RECURRENT ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE RECURRENT ACUTE LYMPHOBLASTIC LEUKEMIA RECURRENT ACUTE MYELOID LEUKEMIA DUE TO LINEAGE SWITCH FROM ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE RECURRENT ACUTE MYELOID LEUKEMIA DUE TO LINEAGE SWITCH FROM B ACUTE LYMPHOBLASTIC LEUKEMIA, KMT2A-REARRANGED RECURRENT ACUTE MYELOID LEUKEMIA DUE TO LINEAGE SWITCH FROM MIXED PHENOTYPE ACUTE LEUKEMIA RECURRENT MIXED PHENOTYPE ACUTE LEUKEMIA REFRACTORY ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA REFRACTORY ACUTE MYELOID LEUKEMIA DUE TO LINEAGE SWITCH FROM ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE REFRACTORY ACUTE MYELOID LEUKEMIA DUE TO LINEAGE SWITCH FROM B ACUTE LYMPHOBLASTIC LEUKEMIA, KMT2A-REARRANGED REFRACTORY ACUTE MYELOID LEUKEMIA DUE TO LINEAGE SWITCH FROM MIXED PHENOTYPE ACUTE LEUKEMIA REFRACTORY MIXED PHENOTYPE ACUTE LEUKEMIA