New drug duo takes aim at hard-to-treat stomach cancer with liver metastases

NCT ID NCT07677293

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This phase 3 trial compares a new drug called Retlirafusp alfa plus chemotherapy against standard immunotherapy plus chemotherapy for people with advanced stomach or gastroesophageal junction cancer that has spread to the liver and has not been treated before. The study aims to see if the new combination helps people live longer without their cancer growing. About 332 participants will be randomly assigned to one of the two treatment groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Retlirafusp alfa

What this could lead to

If successful, this could offer a new first-line treatment option for people with advanced gastric cancer that has spread to the liver.

What could go wrong

This is an early-phase 3 trial, so results may not confirm benefit. The experimental drug may cause side effects or not improve outcomes compared to existing therapies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

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