Can breathing exercises supercharge stroke recovery?

NCT ID NCT05819333

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests whether adding respiratory muscle training to a standard post-stroke wellness program improves breathing strength, physical activity, and quality of life more than the wellness program alone. Stroke survivors who are at least six months post-stroke will participate in an eight-week program of strengthening, cardiovascular, and flexibility exercises, plus either respiratory strengthening or relaxation exercises. Researchers will compare the two groups to see if the respiratory strengthening group shows greater improvements in breathing pressure, cough flow, and daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Respiratory muscle training (strengthening exercises for breathing muscles) combined with a standard stroke wellness program
What this could lead to
If effective, this approach could enhance recovery after stroke, improving breathing strength, physical activity, and quality of life for survivors.
What could go wrong
The trial is relatively small and early, so results may not apply to all stroke survivors. Respiratory training may not provide added benefit over relaxation training.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

85 people

The number who actually took part.

Started

Nov 2020

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 95 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of stroke * Greater than 6 months post-stroke * Signed letter of medical approval from primary care physician to participate in this research study * Community dwelling * Ability to attend the wellness program 3x/week for eight weeks * Ability to follow instructions or mimic exercises * Ability to communicate adverse effects such as pain or fatigue or the need for assistance * Able to ambulate 20 feet with no more than contact guard assist, with or without an assistive device or orthotic device * Able to access exercise equipment independently or with caregiver assist * Greater than 18 years of age Exclusion Criteria: * Neurologic condition other than stroke, i.e. Parkinson's Disease, multiple sclerosis * Severe, functional limiting arthritis * Orthopedic condition that limits mobility * Severe weight-bearing pain * Current participation in other physical rehabilitation services or exercise programs * Serious cardiac conditions (hospitalization for myocardial infarction or heart surgery within the past year, history of congestive heart failure, documented serious and unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living). Anyone meeting New York Heart Association criteria for Class 3 or Class 4 heart disease will be excluded * Severe hypertension: with systolic \> 200 mmHg and diastolic \> 110 mmHg at rest, that cannot be medically controlled into the resting range of 180/100 mmHg * Use of supplemental oxygen at baseline * Severe obstructive pulmonary disease (Classification of Global Initiative for Chronic Obstructive Lung Disease (GOLD)39 3 or higher, indicating FEV1\<50% predicted) * Treatment for pneumonia or lower respiratory infection within the past month * Able to run one-quarter mile without stopping

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Brooks Rehabilitation Hospital

    Jacksonville, Florida, 32216, United States

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