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Scientists probe resistance to targeted lung cancer drug

NCT ID NCT06247826

Recruiting now Knowledge-focused Sponsor: Groupe Francais De Pneumo-Cancerologie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why amivantamab, a drug for advanced non-small cell lung cancer with a specific EGFR mutation, stops working over time. Researchers will collect blood and tumor samples from 30 patients when their disease gets worse. The goal is to find genetic changes that cause resistance and help doctors choose better next treatments.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EGFR EXON 20 INSERTION MUTATION NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • CH Bretagne Atlantique

    RECRUITING

    Vannes, 56017, France

  • CHU Hôpital Nord

    RECRUITING

    Saint-Etienne, 42055, France

  • CHU La Réunion Site Nord

    RECRUITING

    Saint-Denis, 97411, France

  • Centre Hospitalier du Morvan

    RECRUITING

    Brest, 29200, France

  • Hôpital Charles Nicolle

    RECRUITING

    Rouen, 76031, France

  • Hôpital Cochin

    RECRUITING

    Paris, 75014, France

  • Oncologie Institut Curie

    NOT_YET_RECRUITING

    Paris, 75005, France

  • Oncologie Polyclinique Bordeaux Nord Aquitaine

    NOT_YET_RECRUITING

    Bordeaux, 33000, France

  • Oncologie thoracique Hôpital Nord

    RECRUITING

    Marseille, 13915, France

  • Oncologie, CLCC Dijon

    NOT_YET_RECRUITING

    Dijon, 21000, France

  • Oncologie, Centre Antoine Lacassagne

    WITHDRAWN

    Nice, 06149, France

  • Pneumologie CH

    NOT_YET_RECRUITING

    Le Mans, 72000, France

  • Pneumologie CHI Cornouaille

    NOT_YET_RECRUITING

    Quimper, 02900, France

  • Pneumologie Centre Hospitalier

    NOT_YET_RECRUITING

    Pau, 64000, France

  • Pneumologie Centre Hospitalier Intercommunal de Créteil

    RECRUITING

    Créteil, 94010, France

  • Pneumologie, CHU Grenoble

    RECRUITING

    Grenoble, 38043, France

  • Pneumologie, Hôpital Mutualiste Resamut

    NOT_YET_RECRUITING

    Villeurbanne, 69100, France

  • Pneumologie, Hôpital Tenon

    RECRUITING

    Paris, 75970, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.