Heart valve showdown: open surgery vs. less invasive option – which is better?
NCT ID NCT07462624
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two procedures for people whose surgically implanted heart valve has worn out: repeat open-heart surgery (rAVR) or a less invasive catheter-based approach (valve-in-valve TAVR). About 890 patients aged 18–75 at low-to-intermediate surgical risk will be randomly assigned to one of the two procedures. The goal is to see which approach leads to fewer deaths, strokes, heart attacks, or hospital readmissions over five years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Procedure: either open-heart surgery to replace the valve, or a catheter-based valve-in-valve implant
- What this could lead to
- If this trial succeeds, it could show which procedure is safer and more effective for people whose artificial heart valve has worn out, helping doctors choose the best option.
- What could go wrong
- This is a large trial, but results may not apply to everyone (e.g., older or higher-risk patients were excluded). Both procedures carry risks like stroke, bleeding, or heart rhythm problems.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Herzzentrum Leipzig GmbH
RECRUITINGLeipzig, Saxony, 04289, Germany
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