Could a daily pill replace infusions for MS? new trial aims to find out

NCT ID NCT06846281

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This phase 3 trial is testing whether a daily pill called remibrutinib works as well as the standard infusion or injection ocrelizumab for people with relapsing multiple sclerosis. About 360 adults aged 40–70 who are stable on ocrelizumab will either switch to remibrutinib or stay on ocrelizumab. The study will track brain lesions, relapses, and disability progression over two years to see if the switch is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Remibrutinib (daily tablet)
What this could lead to: If successful, this could offer people with relapsing MS a convenient daily pill option instead of regular infusions or injections, while still controlling the disease.
What could go wrong: This is a non-inferiority study, so remibrutinib may not be better than ocrelizumab—just as good or possibly worse. It is also a switch study, so results may not apply to people starting treatment for the first time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSING MULTIPLE SCLEROSIS

Contacts and locations

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Locations

Advent Health Orlando
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Orlando, Florida, 32803, United States
Aqualane Clinical Research
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Naples, Florida, 34105, United States
Austin Regional Clinic
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Austin, Texas, 78731, United States
Center for Neurological Disorders G
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Greenfield, Wisconsin, 53228-1321, United States
Cleveland Clinic Foundation
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Las Vegas, Nevada, 89106, United States
Cleveland Clinic Foundation
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Cleveland, Ohio, 44195, United States
Elite Clinical Research
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Miami, Florida, 33144, United States
Holy Name Medical Center
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Teaneck, New Jersey, 07666, United States
John Peter Smith Hospital
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Fort Worth, Texas, 76104, United States
Lahey Hospital and Medical Center
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Burlington, Massachusetts, 01805, United States
MedStar Montgomery Medical Center
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Olney, Maryland, 20832, United States
Medical College of Wisconsin
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Milwaukee, Wisconsin, 53226, United States
Medstar Washington Hospital Center
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Washington D.C., District of Columbia, 20010-2975, United States
Memorial HC Ins for Neuroscience
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Owosso, Michigan, 48867, United States
Memorial Healthcare System
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Hollywood, Florida, 33021, United States
Michigan Institute of Neurological
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Farmington Hills, Michigan, 48334, United States
Neurology Associates PA
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Maitland, Florida, 32751, United States

Contact Email: •••••@•••••
Neurology Center of New England PC
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Foxborough, Massachusetts, 02035, United States
Neurology of Central FL Res Ctr
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Altamonte Springs, Florida, 32714, United States

Contact Email: •••••@•••••
Novartis Investigative Site
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Rosario, Santa Fe Province, 2000, Argentina
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Rosario, Santa Fe Province, S2000BZL, Argentina
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Buenos Aires, C1055AAF, Argentina
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Caba, C1182, Argentina
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Melbourne, Victoria, 3004, Australia
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Parkville, Victoria, 3050, Australia
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Liverpool, 2170, Australia
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St Leonards, 2065, Australia
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Bruges, 8000, Belgium
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Overpelt, 3900, Belgium
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Fortaleza, Ceará, 60120-002, Brazil
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Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
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Rio Grande, Rio Grande do Sul, 90035-001, Brazil
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São Paulo, São Paulo, 01244-030, Brazil
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São Paulo, São Paulo, 04076-004, Brazil
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Edmonton, Alberta, T6G 2B7, Canada
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Vancouver, British Columbia, V6T 2A1, Canada
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Lévis, Quebec, G6W 0M5, Canada
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Montreal, Quebec, H4A 3T2, Canada
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Brno, 602 00, Czechia
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Jihlava, 586 01, Czechia
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Pardubice, 532 03, Czechia
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Prague, 150 06, Czechia
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Aarhus N, 8200, Denmark
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Glostrup Municipality, 2600, Denmark
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Bordeaux, 33076, France
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Clermont-Ferrand, 63003, France
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Lille, 59000, France
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Marseille, 13885, France
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Nice, 06000, France
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Nîmes, 30029, France
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Paris, 75940, France
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Poitiers, 86021, France
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Strasbourg, 67000, France
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Toulouse, 31059, France
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Tours, 37044, France
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Berlin, 13353, Germany
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Bochum, 44791, Germany
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Erbach im Odenwald, 64711, Germany
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Essen, 45147, Germany
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Greifswald, 17475, Germany
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Heidelberg, 69120, Germany
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Münster, 48149, Germany
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Ulm, 89073, Germany
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Ulm, 89081, Germany
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Chaïdári, 124 62, Greece
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Larissa, 411 10, Greece
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Thessaloniki, 53246, Greece
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Bergamo, BG, 24127, Italy
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Foggia, FG, 71122, Italy
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Genova, GE, 16132, Italy
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Milan, MI, 20132, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00133, Italy
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Roma, RM, 00168, Italy
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Mexico City, Mexico City, 06700, Mexico
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Mexico City, 14050, Mexico
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Braga, 4710243, Portugal
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Coimbra, 3004-561, Portugal
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Lisbon, 1169-050, Portugal
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Bratislava, Slovakia, 826 06, Slovakia
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Trnava, Slovakia, 917 02, Slovakia
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Cape Town, Western Cape, 7405, South Africa
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Pretoria, 0041, South Africa
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El Palmar, Murcia, 30120, Spain
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Valencia, Valencia, 46017, Spain
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Barcelona, 08035, Spain
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Córdoba, 14004, Spain
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Madrid, 28009, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28222, Spain
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Málaga, 29010, Spain
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Seville, 41009, Spain
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Valencia, 46026, Spain
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Bern, 3010, Switzerland
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Lausanne, 1011, Switzerland
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Zurich, 8091, Switzerland
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Sheffield, South Yorkshire, S10 2JF, United Kingdom
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Leeds, LS1 3EX, United Kingdom
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London, W6 8RF, United Kingdom
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Swansea, SA6 6NL, United Kingdom
Ohio Health Research Institute
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Columbus, Ohio, 43214, United States
Orlando Health Clinical Trials
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Orlando, Florida, 32806, United States
Perseverance Research Center
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Scottsdale, Arizona, 85253, United States
Premier Health
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Centerville, Ohio, 45459, United States
Premier Neurology
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Greenville, South Carolina, 29605, United States
Providence Neurological Services West
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Portland, Oregon, 97225, United States
Rush University Medical Center
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Chicago, Illinois, 60607, United States
SUNY Buffalo The Jacobs Neuro Inst
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Buffalo, New York, 14203, United States
Sanford Health
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Fargo, North Dakota, 58122, United States
Saturn Research Solutions LLC
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Plano, Texas, 75024, United States
Sibyl Wray MD Neurology PC
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Knoxville, Tennessee, 37922, United States
Tallahassee Neurological Clinic
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Tallahassee, Florida, 32308, United States
Tufts Medical Center
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Boston, Massachusetts, 02111, United States
Univ of Cincinnati Medical Center
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Cincinnati, Ohio, 45219, United States
Univ of Texas Southwest Med Center
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Dallas, Texas, 75390-9034, United States
University Of South Florida
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Tampa, Florida, 33612, United States
University of California Irvine
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Irvine, California, 92697, United States
University of Chicago
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Chicago, Illinois, 60637, United States
University of Florida
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Gainesville, Florida, 32610, United States
University of Kansas Hospital
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Kansas City, Kansas, 66160, United States
University of New Mexico
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Albuquerque, New Mexico, 87131-0001, United States
Velocity Clinical Research
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Raleigh, North Carolina, 27607, United States
Vero Beach Neurology
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Vero Beach, Florida, 32960, United States
Virginia Commonwealth University
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Richmond, Virginia, 23298-0111, United States
WA Uni School Of Med
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St Louis, Missouri, 63110, United States

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