Could a daily pill replace infusions for MS? new trial aims to find out

NCT ID NCT06846281

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing whether a daily pill called remibrutinib works as well as the standard infusion or injection ocrelizumab for people with relapsing multiple sclerosis. About 360 adults aged 40–70 who are stable on ocrelizumab will either switch to remibrutinib or stay on ocrelizumab. The study will track brain lesions, relapses, and disability progression over two years to see if the switch is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Remibrutinib (daily tablet)

What this could lead to

If successful, this could offer people with relapsing MS a convenient daily pill option instead of regular infusions or injections, while still controlling the disease.

What could go wrong

This is a non-inferiority study, so remibrutinib may not be better than ocrelizumab—just as good or possibly worse. It is also a switch study, so results may not apply to people starting treatment for the first time.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSING MULTIPLE SCLEROSIS

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-••••

Locations

Advent Health Orlando
RECRUITING

Orlando, Florida, 32803, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Aqualane Clinical Research
RECRUITING

Naples, Florida, 34105, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Austin Regional Clinic
RECRUITING

Austin, Texas, 78731, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Center for Neurological Disorders G
RECRUITING

Greenfield, Wisconsin, 53228-1321, United States

Contact

Contact Email: •••••@•••••
Cleveland Clinic Foundation
RECRUITING

Las Vegas, Nevada, 89106, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Holy Name Medical Center
RECRUITING

Teaneck, New Jersey, 07666, United States

Contact Email: •••••@•••••

Contact
John Peter Smith Hospital
RECRUITING

Fort Worth, Texas, 76104, United States

Contact

Contact Email: •••••@•••••
Lahey Hospital and Medical Center
RECRUITING

Burlington, Massachusetts, 01805, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
MedStar Montgomery Medical Center
RECRUITING

Olney, Maryland, 20832, United States

Contact

Contact Email: •••••@•••••
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Medstar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010-2975, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Memorial HC Ins for Neuroscience
RECRUITING

Owosso, Michigan, 48867, United States

Contact

Contact Email: •••••@•••••
Michigan Institute of Neurological
RECRUITING

Farmington Hills, Michigan, 48334, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Neurology Associates PA
RECRUITING

Maitland, Florida, 32751, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Neurology Center of New England PC
RECRUITING

Foxborough, Massachusetts, 02035, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Neurology of Central FL Res Ctr
RECRUITING

Altamonte Springs, Florida, 32714, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Novartis Investigative Site
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Novartis Investigative Site
RECRUITING

Rosario, Santa Fe Province, S2000BZL, Argentina
Novartis Investigative Site
RECRUITING

Buenos Aires, C1055AAF, Argentina
Novartis Investigative Site
RECRUITING

Caba, C1182, Argentina
Novartis Investigative Site
RECRUITING

Melbourne, Victoria, 3004, Australia
Novartis Investigative Site
RECRUITING

Parkville, Victoria, 3050, Australia
Novartis Investigative Site
RECRUITING

Liverpool, 2170, Australia
Novartis Investigative Site
RECRUITING

St Leonards, 2065, Australia
Novartis Investigative Site
RECRUITING

Bruges, 8000, Belgium
Novartis Investigative Site
RECRUITING

Overpelt, 3900, Belgium
Novartis Investigative Site
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Novartis Investigative Site
RECRUITING

Rio Grande, Rio Grande do Sul, 90035-001, Brazil
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 01244-030, Brazil
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 04076-004, Brazil
Novartis Investigative Site
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
Novartis Investigative Site
RECRUITING

Vancouver, British Columbia, V6T 2A1, Canada
Novartis Investigative Site
RECRUITING

Lévis, Quebec, G6W 0M5, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H4A 3T2, Canada
Novartis Investigative Site
RECRUITING

Brno, 602 00, Czechia
Novartis Investigative Site
RECRUITING

Hradec Králové, 500 05, Czechia
Novartis Investigative Site
RECRUITING

Jihlava, 586 01, Czechia
Novartis Investigative Site
RECRUITING

Pardubice, 532 03, Czechia
Novartis Investigative Site
RECRUITING

Aarhus N, 8200, Denmark
Novartis Investigative Site
RECRUITING

Glostrup Municipality, 2600, Denmark
Novartis Investigative Site
RECRUITING

Bordeaux, 33076, France
Novartis Investigative Site
RECRUITING

Clermont-Ferrand, 63003, France
Novartis Investigative Site
RECRUITING

Lille, 59000, France
Novartis Investigative Site
RECRUITING

Marseille, 13885, France
Novartis Investigative Site
RECRUITING

Nice, 06001, France
Novartis Investigative Site
RECRUITING

Nîmes, 30029, France
Novartis Investigative Site
RECRUITING

Paris, 75940, France
Novartis Investigative Site
RECRUITING

Poitiers, 86021, France
Novartis Investigative Site
RECRUITING

Strasbourg, 67000, France
Novartis Investigative Site
RECRUITING

Toulouse, 31059, France
Novartis Investigative Site
RECRUITING

Tours, 37044, France
Novartis Investigative Site
RECRUITING

Berlin, 13353, Germany
Novartis Investigative Site
RECRUITING

Bochum, 44791, Germany
Novartis Investigative Site
RECRUITING

Essen, 45147, Germany
Novartis Investigative Site
RECRUITING

Greifswald, 17475, Germany
Novartis Investigative Site
RECRUITING

Heidelberg, 69120, Germany
Novartis Investigative Site
RECRUITING

Münster, 48149, Germany
Novartis Investigative Site
RECRUITING

Ulm, 89073, Germany
Novartis Investigative Site
RECRUITING

Ulm, 89081, Germany
Novartis Investigative Site
RECRUITING

Chaïdári, 124 62, Greece
Novartis Investigative Site
RECRUITING

Larissa, 411 10, Greece
Novartis Investigative Site
RECRUITING

Thessaloniki, 53246, Greece
Novartis Investigative Site
RECRUITING

Bergamo, BG, 24127, Italy
Novartis Investigative Site
RECRUITING

Foggia, FG, 71122, Italy
Novartis Investigative Site
RECRUITING

Genova, GE, 16132, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20132, Italy
Novartis Investigative Site
RECRUITING

Pavia, PV, 27100, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00133, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00168, Italy
Novartis Investigative Site
RECRUITING

Mexico City, Mexico City, 06700, Mexico
Novartis Investigative Site
RECRUITING

Mexico City, 14050, Mexico
Novartis Investigative Site
RECRUITING

Braga, 4710243, Portugal
Novartis Investigative Site
RECRUITING

Coimbra, 3004-561, Portugal
Novartis Investigative Site
RECRUITING

Lisbon, 1169-050, Portugal
Novartis Investigative Site
RECRUITING

Bratislava, Slovakia, 826 06, Slovakia
Novartis Investigative Site
RECRUITING

Trnava, Slovakia, 917 02, Slovakia
Novartis Investigative Site
RECRUITING

Cape Town, Western Cape, 7405, South Africa
Novartis Investigative Site
RECRUITING

Pretoria, 0041, South Africa
Novartis Investigative Site
RECRUITING

El Palmar, Murcia, 30120, Spain
Novartis Investigative Site
RECRUITING

Valencia, Valencia, 46017, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08035, Spain
Novartis Investigative Site
RECRUITING

Córdoba, 14004, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28009, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28034, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28040, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28222, Spain
Novartis Investigative Site
RECRUITING

Málaga, 29010, Spain
Novartis Investigative Site
RECRUITING

Seville, 41009, Spain
Novartis Investigative Site
RECRUITING

Valencia, 46026, Spain
Novartis Investigative Site
RECRUITING

Bern, 3010, Switzerland
Novartis Investigative Site
RECRUITING

Lausanne, 1011, Switzerland
Novartis Investigative Site
RECRUITING

Zurich, 8091, Switzerland
Novartis Investigative Site
RECRUITING

Sheffield, South Yorkshire, S10 2JF, United Kingdom
Novartis Investigative Site
RECRUITING

Leeds, LS1 3EX, United Kingdom
Novartis Investigative Site
RECRUITING

London, W6 8RF, United Kingdom
Novartis Investigative Site
RECRUITING

Swansea, SA6 6NL, United Kingdom
Ohio Health Research Institute
RECRUITING

Columbus, Ohio, 43214, United States

Contact

Contact Email: •••••@•••••
Orlando Health Clinical Trials
RECRUITING

Orlando, Florida, 32806, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Perseverance Research Center
RECRUITING

Scottsdale, Arizona, 85253, United States

Contact Email: •••••@•••••

Contact
Premier Health
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••

Contact
Premier Neurology
RECRUITING

Greenville, South Carolina, 29605, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60607, United States

Contact

Contact Email: •••••@•••••
SUNY Buffalo The Jacobs Neuro Inst
RECRUITING

Buffalo, New York, 14203, United States

Contact

Contact Email: •••••@•••••
Sanford Health
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••

Contact
Saturn Research Solutions LLC
RECRUITING

Plano, Texas, 75024, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Sibyl Wray MD Neurology PC
RECRUITING

Knoxville, Tennessee, 37922, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Tallahassee Neurological Clinic
RECRUITING

Tallahassee, Florida, 32308, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Univ of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Univ of Texas Southwest Med Center
RECRUITING

Dallas, Texas, 75390-9034, United States

Contact Email: •••••@•••••

Contact
University Of South Florida
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of California Irvine
RECRUITING

Irvine, California, 92697, United States

Contact

Contact Email: •••••@•••••
University of Florida
RECRUITING

Gainesville, Florida, 32610, United States

Contact

Contact Email: •••••@•••••
University of Kansas Hospital
RECRUITING

Kansas City, Kansas, 66160, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87131-0001, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Velocity Clinical Research
RECRUITING

Raleigh, North Carolina, 27607, United States

Contact

Contact Email: •••••@•••••
Vero Beach Neurology
RECRUITING

Vero Beach, Florida, 32960, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298-0111, United States

Contact Email: •••••@•••••

Contact
WA Uni School Of Med
RECRUITING

St Louis, Missouri, 63110, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact