New pill shows promise for stubborn hives in Head-to-Head trial

NCT ID NCT06868212

Recruiting now Symptom relief Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new daily pill (remibrutinib) against a standard injected drug (dupilumab) for adults with chronic hives that antihistamines can't control. About 400 participants will take either the pill or get the shot for 4 weeks to see which works faster. The goal is to reduce itching and hives quickly.

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Conditions

The condition(s) this trial relates to.

chronic idiopathic urticaria Chronic Urticaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC SPONTANEOUS URTICARIA (CSU)

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Accellacare Duly Health and Care
RECRUITING

Wheaton, Illinois, 60189, United States

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Acuro Research Inc
RECRUITING

Little Rock, Arkansas, 72205, United States

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Aeroallergy Research Laboratories
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Savannah, Georgia, 31406, United States

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AllerVie Clin Res Columbus GA
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Columbus, Georgia, 31904, United States

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AllerVie Clin Res Glenn Dale
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Glenn Dale, Maryland, 20769, United States

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AllerVie Health
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Panama, Florida, 32405, United States

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Allergic Disease and Asthma Center
RECRUITING

Greenville, South Carolina, 29607, United States

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Allergy Associates of Utah
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Sandy City, Utah, 84093, United States

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Allergy Asthma Assoc Monmouth
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Little Silver, New Jersey, 07739, United States

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Allergy Partners Of West NC
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Asheville, North Carolina, 28801, United States

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Allergy Partners of New Jersey PC
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Ocean Township, New Jersey, 07712, United States

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Allergy and Asthma Center of Las Vegas
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Las Vegas, Nevada, 89128, United States

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Allergy and Asthma Clin Res Inc
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Walnut Creek, California, 94598, United States

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Allergy and Asthma Consultants
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Redwood City, California, 94063, United States

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Allergy and Asthma Specialist P S C
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Owensboro, Kentucky, 42301, United States

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Allergy and Asthma Specialists Group
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Huntington Beach, California, 92647, United States

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Allergy and Clinical Immunology Associates
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Pittsburgh, Pennsylvania, 15241, United States

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Allervie Clinical Research
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Birmingham, Alabama, 35209, United States

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Andante Research
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San Antonio, Texas, 78229, United States

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Ark Clinical Research
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Long Beach, California, 90815, United States

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Arlington Center for Dermatology
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Arlington, Texas, 76011, United States

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Asthma Allergy Immunology Clin Res
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Tampa, Florida, 33613, United States

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Asthma and Allergy Associates P C
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Colorado Springs, Colorado, 80907, United States

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Asthma and Allergy Center of Chicago S C
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River Forest, Illinois, 60305, United States

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Avacare Center for Dermatology
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Phoenix, Arizona, 85044, United States

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Bellaire Dermatology Associates
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Bellaire, Texas, 77401, United States

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Bellingham Asthma Allergy and Immunology
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Bellingham, Washington, 98225, United States

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Bernstein Clinical Research Center
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Cincinnati, Ohio, 45231, United States

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Boston Specialists LLC
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Boston, Massachusetts, 02111, United States

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CR Services Acquisition US
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Columbus, Ohio, 43213, United States

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Cahaba Derm and skin hlth ctr 27
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Birmingham, Alabama, 35244, United States

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California Allergy and Asthma Medical Group
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Los Angeles, California, 90025, United States

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Center for Clinical Studies
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Houston, Texas, 77030, United States

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Charleston ENT and Allergy
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North Charleston, South Carolina, 29406, United States

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Chesapeake Clinical Research Inc
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Baltimore, Maryland, 21236, United States

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Circuit Clinical
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Riverdale, New Jersey, 07457, United States

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Circuit Clinical Mercer Algy Pulm
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Hamilton, New Jersey, 08619, United States

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Cleaver Medical Group
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Cumming, Georgia, 30040, United States

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Clin Trial Inst of Northwest AR
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Fayetteville, Arkansas, 72703, United States

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ClinSite Inc
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Ann Arbor, Michigan, 48106-0525, United States

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Clinical Res Ctr of S Illinois
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O'Fallon, Illinois, 62269, United States

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Clinical Research Institute
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Minneapolis, Minnesota, 55402, United States

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Colorado ENT and Allergy
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Colorado Springs, Colorado, 80909, United States

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Conquest Research
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Winter Park, Florida, 32789, United States

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Ctr for Dermatology Clinical Res
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Fremont, California, 95438, United States

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Deaconess Clin Allerg Res Inst
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Evansville, Indiana, 47715, United States

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Derm Institute West Michigan PLLC
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Caledonia, Michigan, 49316, United States

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Dermatology Institute and Skin Care
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Santa Monica, California, 90404, United States

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Dermatology Research Associates
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Los Angeles, California, 90045, United States

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ENT and Allergy Center of Missouri
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Columbia, Missouri, 65201, United States

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Empire Clinical Research
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Pomona, California, 91767, United States

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Endeavor Health Clinical Trials Center
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Skokie, Illinois, 60077, United States

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Equity Medical
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The Bronx, New York, 10455, United States

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Equity Medical LLC
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Bowling Green, Kentucky, 42104, United States

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FXM Clin Res Miramar LLC
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Miramar, Florida, 33027, United States

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FXM Clinical Res Miami LLC
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Miami, Florida, 33175, United States

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FXM Clinical Research Ft Laud
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Fort Lauderdale, Florida, 33308, United States

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Family Allergy And Asthma Rsch Inst
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Louisville, Kentucky, 40215, United States

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First OC Dermatology
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Fountain Valley, California, 92708, United States

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Florida Ctr Allergy Asthma Research
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Aventura, Florida, 33180, United States
Florida Ctr Allergy Asthma Research
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Aventura, Florida, 33180, United States

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Forefront Dermatology
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Vienna, Virginia, 22182, United States

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Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Howard University Hospital Division of Geriatrics
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Washington D.C., District of Columbia, 20059, United States

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Hudson Essex Allergy-Circuit Clinical
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Belleville, New Jersey, 07109, United States

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Institute for Asthma and Allergy PC
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Chevy Chase, Maryland, 20815, United States

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Integrated Research of Inland Inc
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Upland, California, 91786, United States

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Integrative Skin Science and Res
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Sacramento, California, 95815, United States

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International Clinical Research Tennessee LCC
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Murfreesboro, Tennessee, 37130, United States

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Jacksonville Center for Clinical Research
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Jacksonville, Florida, 32216, United States

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Johns Hopkins U School of Med
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Baltimore, Maryland, 21205, United States

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Las Vegas Dermatology
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Las Vegas, Nevada, 89144, United States

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Lenus Research and Med Group LLC
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Sweetwater, Florida, 33172, United States

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Mayo Clinic - Rochester
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Rochester, Minnesota, 55905, United States

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McFarland Clinic PC
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Ames, Iowa, 50010, United States

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Medical Univ Of SC Medical Ctr
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Charleston, South Carolina, 29425, United States

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Miami Dade Medical Research
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Miami, Florida, 33176, United States

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Midwest Allergy Sinus Asthma SC
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Normal, Illinois, 61761, United States

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Montefiore Medical Center
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The Bronx, New York, 10467, United States

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NW Uni C and T Sciences Ins
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Chicago, Illinois, 60611, United States

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National Allergy and Asthma Research LLS
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North Charleston, South Carolina, 29420, United States

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Norcal Clinical Research
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Rocklin, California, 95765, United States

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Ochsner Health Center
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Baton Rouge, Louisiana, 70816, United States

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Olympian Clinical Research
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Tampa, Florida, 33609, United States

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Omnicure Clinical Research
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Doral, Florida, 33172, United States

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One Of A Kind Clinical Research
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Napa, California, 94558, United States

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Optimed Research LLC
WITHDRAWN

Columbus, Ohio, 43235, United States
Oregon Health Sciences University
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Portland, Oregon, 97239, United States

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Oregon Medical Research Center
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Portland, Oregon, 97223, United States

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Orion Clinical Research
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Austin, Texas, 78759, United States

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Orso Health
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Scottsdale, Arizona, 85254, United States

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Orso Health
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Long Beach, California, 90808, United States

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Peak Dermatology
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Payson, Arizona, 85541, United States

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Peninsula Research Associates
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Rolling Hills Estates, California, 90274, United States

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Pharma Research and Amp Consult
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Dallas, Texas, 75231, United States

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Premier Allergy Asthma And Immunology
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Phoenix, Arizona, 85032, United States

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RFSA Dermatology
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San Antonio, Texas, 78213, United States

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Research Solutions of Arizona
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Litchfield Park, Arizona, 85340, United States

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Reveal Research Institute
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Dallas, Texas, 75230, United States

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Revival Research Institute
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Troy, Michigan, 48084, United States

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Sante Clinical Research
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Kerrville, Texas, 78028, United States

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Sarasota Clinical Research
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Sarasota, Florida, 34233, United States

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Skin Care Research Inc
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Boca Raton, Florida, 33486, United States

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Skin Care Research LLC
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Hollywood, Florida, 33021, United States

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Skylight Health Res Inc Color Spr
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Colorado Springs, Colorado, 80917, United States

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Somerset Skin Centre
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Troy, Michigan, 48084, United States

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Somnos Clinical Research
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Lincoln, Nebraska, 68510, United States

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Southeast Dermatology Specialists
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Douglasville, Georgia, 30135, United States

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Southern IN Clinical Trials
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New Albany, Indiana, 47150, United States

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The Allergy Group-Meridian Clinic
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Meridian, Idaho, 83642, United States

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The Clinical Research Center
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St Louis, Missouri, 63141, United States

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Therapeutics Clinical Research
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San Diego, California, 92123, United States

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Toledo Institute of Clinical Research
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Toledo, Ohio, 43617, United States

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Tribe Clinical Research LLC
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Greenville, South Carolina, 29601, United States

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UC Davis Neuromuscular Research Center
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Sacramento, California, 95817, United States

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UCONN Health Dermatology
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Farmington, Connecticut, 06030-2840, United States

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UNC DermatologyandSkinCancer Ctr
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Chapel Hill, North Carolina, 27516, United States

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Unity Clinical Research
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Oklahoma City, Oklahoma, 73118, United States

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University Of Utah
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Murray, Utah, 84107, United States

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University of Colorado Hospital - Aurora
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Aurora, Colorado, 80045, United States

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University of MiamiHealth System
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Miami, Florida, 33125, United States

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University of Minnesota
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Minneapolis, Minnesota, 55455, United States

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Velocity Clinical Research
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Lafayette, Louisiana, 70508, United States

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Vital Prospects Clinical Research Institute
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Tulsa, Oklahoma, 74136, United States

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Washington University
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St Louis, Missouri, 63141, United States

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Western Sky Medical Research
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El Paso, Texas, 79924, United States

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Wright State University
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Fairborn, Ohio, 45324, United States

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Ziaderm Research LLC
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North Miami Beach, Florida, 33162, United States

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