New pill could ease painful skin condition

NCT ID NCT06840392

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 3 study tests an oral drug called remibrutinib in 565 people with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Participants receive one of two doses of remibrutinib or a placebo for 68 weeks. The main goal is to see if the drug reduces the number of inflamed nodules and abscesses by at least half at week 16.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

remibrutinib (an oral drug that targets inflammation)

What this could lead to

If it works, this could provide a new oral treatment option for people with moderate to severe hidradenitis suppurativa, reducing painful flare-ups and improving daily life.

What could go wrong

This is a phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects could occur. It is not a cure, and ongoing treatment may be needed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

dermatitis hidradenitis hidradenitis suppurativa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIDRADENITIS SUPPURATIVA

Contacts and locations

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Locations

Accurate Clinical Research

Humble, Texas, 77346, United States
Alma Cruz-Santana Private Practice

Carolina, 00985, Puerto Rico
Apex Clinical Research Center LLC

Mayfield Heights, Ohio, 44124, United States
Atlanta Biomedical Clin Res LLC

Atlanta, Georgia, 30331, United States
Austin Inst for Clinical Research

Pflugerville, Texas, 78660, United States
Beth Israel Deaconess Med Center

Boston, Massachusetts, 02215, United States
CTT Research

Gilbert, Arizona, 85234, United States
Cameron Dermatology

New York, New York, 10023, United States
Care Access Alexandria

Arlington, Virginia, 22206, United States
Center for Clinical Studies-Lee

Webster, Texas, 77598, United States
Clinical Research Ctr of Carolinas

Charleston, South Carolina, 29407, United States
Clinical Research Inst of MI

Chesterfield, Michigan, 48047, United States
Complexions Dermatology

Danville, Virginia, 24541, United States
Ctr Dermatology and Plastic Surgery

Scottsdale, Arizona, 85260, United States
Ctr for Dermatology Clinical Res

Fremont, California, 95438, United States
Deluxe Dermatology

St Louis, Missouri, 63117, United States
Driven Research

Coral Gables, Florida, 33134, United States
Dundee Dermatology

West Dundee, Illinois, 60118, United States
Emory School of Med Dermatology

Atlanta, Georgia, 30303, United States
Endeavor Health

Glenview, Illinois, 60077, United States
Floridian Research Institute

Miami, Florida, 33179, United States
Forefront Dermatology

Vienna, Virginia, 22182, United States
Goodlettsville Dermatology Research

Goodlettsville, Tennessee, 37072-2301, United States
MedDerm Associates

San Diego, California, 92103, United States
Metro Boston Clinical Partners

Brighton, Massachusetts, 02135, United States
North Shore University Hospital

New Hyde Park, New York, 11040, United States
Northwestern University

Chicago, Illinois, 60611, United States
Novartis Investigative Site

CABA, C1012AAY, Argentina
Novartis Investigative Site

Caba, C1205AAO, Argentina
Novartis Investigative Site

Córdoba, B5000, Argentina
Novartis Investigative Site

Linz, 4020, Austria
Novartis Investigative Site

Brussels, Brussels Capital, 1070, Belgium
Novartis Investigative Site

Leuven, Vlaams Brabant, 3000, Belgium
Novartis Investigative Site

Liège, 4000, Belgium
Novartis Investigative Site

Edmonton, Alberta, T6G 1C3, Canada
Novartis Investigative Site

London, Ontario, N6H 5L5, Canada
Novartis Investigative Site

Montreal, Quebec, H1Y 3L1, Canada
Novartis Investigative Site

Québec, Quebec, G1V 4T3, Canada
Novartis Investigative Site

Sherbrooke, Quebec, J1G 1X9, Canada
Novartis Investigative Site

Medellín, Antioquia, 050010, Colombia
Novartis Investigative Site

Bogota, Cundinamarca, 110221, Colombia
Novartis Investigative Site

Bogota, Cundinamarca, 111411, Colombia
Novartis Investigative Site

Medellín, 050012, Colombia
Novartis Investigative Site

Karlovy Vary, 360 01, Czechia
Novartis Investigative Site

Plzen Bolevec, 32300, Czechia
Novartis Investigative Site

Prague, 100 34, Czechia
Novartis Investigative Site

Prague, 128 08, Czechia
Novartis Investigative Site

Prague, 150 06, Czechia
Novartis Investigative Site

Prague, 180 81, Czechia
Novartis Investigative Site

Brest, 29609, France
Novartis Investigative Site

La Rochelle, 17019, France
Novartis Investigative Site

Lyon, 69003, France
Novartis Investigative Site

Nice, 06000, France
Novartis Investigative Site

Reims, 51100, France
Novartis Investigative Site

Rouen, 76031, France
Novartis Investigative Site

Toulouse, 31400, France
Novartis Investigative Site

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Novartis Investigative Site

Würzburg, Bavaria, 97080, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 60590, Germany
Novartis Investigative Site

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Novartis Investigative Site

Merzig, Saarland, 66663, Germany
Novartis Investigative Site

Leipzig, Saxony, 04103, Germany
Novartis Investigative Site

Bad Bentheim, 48455, Germany
Novartis Investigative Site

Berlin, 13595, Germany
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Dortmund, 44137, Germany
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Hamburg, 20246, Germany
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Lübeck, 23538, Germany
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Minden, 32429, Germany
Novartis Investigative Site

München, 80377, Germany
Novartis Investigative Site

Athens, 161 21, Greece
Novartis Investigative Site

Chaïdári, 124 62, Greece
Novartis Investigative Site

Thessaloniki, 564 03, Greece
Novartis Investigative Site

Pécs, Baranya, 7623, Hungary
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site

Debrecen, Hajdú-Bihar, 4031, Hungary
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Budapest, 1036, Hungary
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Budapest, H-1083, Hungary
Novartis Investigative Site

Kecskemét, 6001, Hungary
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Szeged, 6725, Hungary
Novartis Investigative Site

Kuala Lumpur, Kuala Lumpur, 50586, Malaysia
Novartis Investigative Site

Ipoh, Perak, 30450, Malaysia
Novartis Investigative Site

Kota Kinabalu, Sabah, 88586, Malaysia
Novartis Investigative Site

Johor Bahru, 80100, Malaysia
Novartis Investigative Site

Selangor Darul Ehsan, 68100, Malaysia
Novartis Investigative Site

Wilayah Persekutuan, 62502, Malaysia
Novartis Investigative Site

Monterrey, Nuevo León, 64460, Mexico
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Culiacán, Sinaloa, 80020, Mexico
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Durango, 34000, Mexico
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Warsaw, Masovian Voivodeship, 02-953, Poland
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Warsaw, 02-507, Poland
Novartis Investigative Site

Warsaw, 02-962, Poland
Novartis Investigative Site

Bucharest, District 2, 020125, Romania
Novartis Investigative Site

Bucharest, District 2, 020762, Romania
Novartis Investigative Site

Bucharest, 010825, Romania
Novartis Investigative Site

Timișoara, 300188, Romania
Novartis Investigative Site

Granada, Andalusia, 18014, Spain
Novartis Investigative Site

Palma, Balearic Islands, 07120, Spain
Novartis Investigative Site

Barcelona, 08041, Spain
Novartis Investigative Site

Granollers, 08402, Spain
Novartis Investigative Site

Las Palmas GC, 35010, Spain
Novartis Investigative Site

Madrid, 28002, Spain
Novartis Investigative Site

Madrid, 28041, Spain
Novartis Investigative Site

Pontevedra, 36003, Spain
Novartis Investigative Site

Seville, 41009, Spain
Novartis Investigative Site

Valencia, 46026, Spain
Novartis Investigative Site

Izmir, Balcova, 35340, Turkey (Türkiye)
Novartis Investigative Site

Ankara, Bilkent-Cankaya, 06800, Turkey (Türkiye)
Novartis Investigative Site

Izmir, Buca, 35390, Turkey (Türkiye)
Novartis Investigative Site

Aydin, Efeler, 09100, Turkey (Türkiye)
Novartis Investigative Site

Denizli, Kinikli, 20070, Turkey (Türkiye)
Novartis Investigative Site

Ankara, Yenimahalle, 06500, Turkey (Türkiye)
Novartis Investigative Site

Mersin, Yenisehir, 33110, Turkey (Türkiye)
Novartis Investigative Site

Izmir, 35100, Turkey (Türkiye)
Novartis Investigative Site

Kecioren Ankara, 06010, Turkey (Türkiye)
Novartis Investigative Site

Leeds, West Yorkshire, LS7 4SA, United Kingdom
Novartis Investigative Site

Bristol, BS1 3NU, United Kingdom
Novartis Investigative Site

Cardiff, CF14 4XW, United Kingdom
Novartis Investigative Site

London, E1 2AT, United Kingdom
Novartis Investigative Site

London, SE1 9RT, United Kingdom
Novartis Investigative Site

London, SE5 9RS, United Kingdom
Novartis Investigative Site

Southampton, SO16 6YD, United Kingdom
Ohio State University

Columbus, Ohio, 43210, United States
Optima Research Boardman

Boardman, Ohio, 44512, United States
Sarasota Arthritis Res Ctr

Sarasota, Florida, 34239, United States
Skin Specialists PC

Omaha, Nebraska, 68144, United States
Southern IN Clinical Trials

New Albany, Indiana, 47150, United States
Total Skin and Beauty Dermatology Center PC

Birmingham, Alabama, 35205, United States
USC Keck School of Medicine

Los Angeles, California, 90033, United States
University Of South Florida

Tampa, Florida, 33612, United States
Vivida Dermatology

Las Vegas, Nevada, 89119, United States
Wright State University

Fairborn, Ohio, 45324, United States