New pill could ease painful skin condition

NCT ID NCT06799000

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests an oral drug called remibrutinib in 588 people with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. The study compares two doses of the drug against a placebo over 68 weeks. The main goal is to see if the drug reduces the number of inflamed nodules and abscesses by at least half after 16 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

remibrutinib (an oral drug that targets inflammation)

What this could lead to

If it works, this could provide a new oral treatment option for people with moderate to severe hidradenitis suppurativa, reducing painful flare-ups and improving quality of life.

What could go wrong

This is a phase 3 trial, but results are not yet available. The drug may not work better than placebo, and side effects are possible. It is not a cure, and ongoing treatment may be needed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

dermatitis hidradenitis hidradenitis suppurativa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIDRADENITIS SUPPURATIVA

Contacts and locations

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Locations

Advanced Research Experts

Nashville, Tennessee, 37211, United States
Arkansas Research Trials

North Little Rock, Arkansas, 72117, United States
Bellaire Dermatology Associates

Bellaire, Texas, 77401, United States
Care Access Hoboken

Hoboken, New Jersey, 07030, United States
Cheryl Effron MD Inc

Anaheim, California, 92807, United States
Clinical Trials Research Institute

Thousand Oaks, California, 91320, United States
Dawes Fretzin Clinical Rea Group

Indianapolis, Indiana, 46256, United States
Dermat. and Adv. Aesthetics

Lake Charles, Louisiana, 70605, United States
Equity Medical LLC

Bowling Green, Kentucky, 42104, United States
Essential Medical Research

Tulsa, Oklahoma, 74137, United States
Florida Academic Centers Research and Education LLC

Coral Gables, Florida, 33134, United States
Forest Hills Dermatology Group

New York, New York, 10003, United States
Gwinnett Clinical Research Center

Snellville, Georgia, 30078, United States
Henry Ford Hospital

Detroit, Michigan, 48202-2689, United States
Howard University College of Medicine

Washington D.C., District of Columbia, 20060, United States
Icahn School Of Med At Mount Sinai

New York, New York, 10029, United States
Illinois Dermatology Institute

Chicago, Illinois, 60602, United States
Immunology-Rheumatology Research

Suwanee, Georgia, 30024, United States
Johnson Dermatology

Fort Smith, Arkansas, 72916, United States
Medical Dermatology Specialists

Phoenix, Arizona, 85006, United States
Medical University of South Carolina MUSC

Charleston, South Carolina, 29425, United States
Michigan Center for Rsrch Company

Clarkston, Michigan, 48346, United States
Novartis Investigative Site

Caba, Buenos Aires, C1119ACN, Argentina
Novartis Investigative Site

CABA, Buenos Aires, C1425BEA, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, 2000, Argentina
Novartis Investigative Site

CABA, C1428DZF, Argentina
Novartis Investigative Site

Phillip, Australian Capital Territory, 2606, Australia
Novartis Investigative Site

Sydney, New South Wales, 2010, Australia
Novartis Investigative Site

Westmead, New South Wales, 2145, Australia
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Melbourne, Victoria, 3004, Australia
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Parkville, Victoria, 3050, Australia
Novartis Investigative Site

Sofia, 1407, Bulgaria
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Stara Zagora, 6000, Bulgaria
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Surrey, British Columbia, V3V 0C6, Canada
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St. John's, Newfoundland and Labrador, A1E 1V4, Canada
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Hamilton, Ontario, L8L 3C3, Canada
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Richmond Hill, Ontario, L4C 9M7, Canada
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Québec, Quebec, G1W 4R4, Canada
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Saint-Jérôme, Quebec, J7Z 7E2, Canada
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Fuzhou, Fujian, 350025, China
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Guangzhou, Guangdong, 510000, China
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Wuhan, Hubei, 430022, China
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Changsha, Hunan, 410008, China
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Changchun, Jilin, 130021, China
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Shenyang, Liaoning, 110011, China
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Xian, Shanxi, 710004, China
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Chengdu, Sichuan, 610041, China
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Ürümqi, Xinjiang, 830001, China
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Ningbo, Zhejiang, 315016, China
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Beijing, 100144, China
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Jinan, 250012, China
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Barranquilla, Atlántico, 080002, Colombia
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Bogota, Cundinamarca, 110221, Colombia
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Cali, Valle del Cauca Department, 760032, Colombia
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Medellín, 050034, Colombia
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Roskilde, 4000, Denmark
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Langenau, Baden-Wurttemberg, 89129, Germany
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Darmstadt, Hesse, 64283, Germany
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Dresden, Saxony, 01307, Germany
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Halle, Saxony-Anhalt, 06108, Germany
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Berlin, 10789, Germany
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Berlin, 13353, Germany
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Bochum, 44791, Germany
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Bonn, 53105, Germany
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Erlangen, 91054, Germany
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Hamburg, 20095, Germany
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Hanover, 30159, Germany
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Kiel, 24105, Germany
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Mainz, 55131, Germany
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Münster, 48149, Germany
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Chaïdári, 124 62, Greece
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Heraklion Crete., 715 00, Greece
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Thessaloniki, 546 43, Greece
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Ancona, AN, 60126, Italy
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Brescia, BS, 25123, Italy
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Catania, CT, 95123, Italy
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Cona, FE, 44124, Italy
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Florence, FI, 50122, Italy
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Rozzano, MI, 20089, Italy
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Modena, MO, 41124, Italy
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Pisa, PI, 56126, Italy
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Roma, RM, 00168, Italy
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Torino, TO, 10126, Italy
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Muar town, Johor, 84000, Malaysia
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George Town, Pulau Pinang, 10450, Malaysia
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Kuching, Sarawak, 93586, Malaysia
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Kuala Terengganu, Terengganu, 20400, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Guadalajara, Jalisco, 44340, Mexico
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Guadalajara, Jalisco, 44650, Mexico
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Cuauhtémoc, Mexico City, 06100, Mexico
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Chihuahua City, 31203, Mexico
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Bydgoszcz, 85-094, Poland
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Gdansk, 80-214, Poland
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Lodz, 90-436, Poland
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Almada, 2805-267, Portugal
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Braga, 4710243, Portugal
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Coimbra, 3004-561, Portugal
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Lisbon, 1169-050, Portugal
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Lisbon, 1998-018, Portugal
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Porto, 4099-001, Portugal
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Bratislava, 811 09, Slovakia
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Bratislava, 813 69, Slovakia
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Prešov, 080 01, Slovakia
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Trnava, 917 02, Slovakia
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Raslouw Centurion, Gauteng, 0157, South Africa
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Soweto, Gauteng, 2013, South Africa
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Cape Town, 7505, South Africa
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Durban, 4058, South Africa
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Cadiz, Andalusia, 11009, Spain
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Badalona, Barcelona, 08916, Spain
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Sabadell, Barcelona, 08208, Spain
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Barcelona, Catalonia, 08003, Spain
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Manises, Valencia, 46940, Spain
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Valencia, Valencia, 46017, Spain
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Madrid, 28009, Spain
Novartis Investigative Site

Madrid, 28046, Spain
Novartis Investigative Site

Valencia, 46014, Spain
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Basel, 4031, Switzerland
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Bern, 3010, Switzerland
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Zurich, 8091, Switzerland
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Kaohsiung City, 83301, Taiwan
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Taipei, 10002, Taiwan
Novartis Investigative Site

Taoyuan, 33305, Taiwan
Olive View UCLA Medical Center

Sylmar, California, 91342, United States
OnSite Clinical Solutions LLC

Huntersville, North Carolina, 28078, United States
Physioseq

Sacramento, California, 95826, United States
RFSA Dermatology

San Antonio, Texas, 78213, United States
Revival Research Institute

Troy, Michigan, 48084, United States
Revival Research Institute LLC

Evans, Georgia, 30809, United States
Skinsearch of Rochester Inc

Rochester, New York, 14623, United States
UP Medical Center H System

Pittsburgh, Pennsylvania, 15213-3403, United States
Unity Clinical Research

Oklahoma City, Oklahoma, 73118, United States
University of MiamiHealth System

Miami, Florida, 33125, United States
University of Mississippi Med Ctr

Jackson, Mississippi, 39216, United States
Virginia Clinical Research

Norfolk, Virginia, 23507, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27104, United States
Ziaderm Research LLC

North Miami Beach, Florida, 33162, United States