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New Pill-and-Antibody combo may replace chemo for common lymphoma

NCT ID NCT01650701

Completed Disease control Sponsor: The Lymphoma Academic Research Organisation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a combination of two drugs (rituximab and lenalidomide) works better than standard chemotherapy plus rituximab for people with untreated follicular lymphoma, a slow-growing blood cancer. About 1,030 adults with advanced disease who needed treatment took part. The goal was to see if the new combo could control the disease longer and improve response rates without the side effects of chemo.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOLLICULAR LYMPHOMA

Contacts and locations

Locations

  • Atlantic Health Sciences Corp - Saint John Regional Hospital

    Halifax, Nova Scotia, Canada

  • BCCA - Vancouver Cancer Centre

    Vancouver, British Columbia, Canada

  • CHU Claude Huriez

    Lille, France

  • CHU Mont-Godinne

    Yvoir, Belgium

  • CHUM Hopital Notre-Dame

    Montreal, Quebec, Canada

  • Concord Repatriation General Hospital

    Concord, New South Wales, Australia

  • Cross Cancer Institute

    Edmonton, Alberta, Canada

  • Fraser Valley Cancer Centre

    Surrey, British Columbia, Canada

  • Hospital Clínico Universitario de Valencia

    Valencia, Spain

  • Hospital Clínico de Barcelona

    Barcelona, Spain

  • Hospital Costa del Sol

    Marbella, Spain

  • Hospital Ramon y Cajal

    Madrid, Spain

  • Hospital Son Llatzer

    Palma, Mallorca, Spain

  • Hospital Universitario Mutua de Terrassa

    Terrassa, Barcelona, Spain

  • Hospital Universitario Salamanca

    Salamanca, Spain

  • Hospital Universitario Vall d´Hebron

    Barcelona, Spain

  • Hospital Universitario de Canarias

    Santa Cruz de Tenerife, Canary Islands, Spain

  • Hospital Virgen del Rocio

    Seville, Andaloucia, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Spain

  • Hôpital de l'Enfant-Jesus, CHU de Quebec

    Québec, Quebec, Canada

  • Institut Català d'Oncologia de Girona (ICO Girona)

    Girona, Spain

  • Instituto Português Oncologia

    Lisbon, Portugal

  • LMU Munchën - Klinikum Grosshadern

    München, Germany

  • McGill University Department of Oncology

    Montreal, Quebec, Canada

  • Medizinische Klinik der Universität Tübingen

    Tübingen, Baden-Wurttemberg, Germany

  • Moncton Hospital

    Moncton, New Brunswick, Canada

  • Nepean Hospital

    Penrith, New South Wales, Australia

  • Policlinico Sant'Orsola-Malpighi

    Bologna, Italy

  • Sant'Andrea Hospital

    Rome, Lazio, Italy

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, Canada

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, Canada

  • Tom Baker Cancer Centre

    Calgary, Alberta, Canada

  • UHN-Princess Margaret Hospital

    Toronto, Ontario, Canada

  • Uniklinik Köln

    Cologne, Nordrhein, Germany

  • Wollongong Hospital

    Wollongong, New South Wales, Australia

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