New drug shows promise for Hard-to-Treat blood cancers

NCT ID NCT02290951

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 28 times

Summary

This early-stage study tested a new drug called odronextamab (REGN1979) in 200 people with B-cell blood cancers like non-Hodgkin lymphoma and chronic lymphocytic leukemia that had stopped responding to prior treatments. The goal was to check the drug's safety and find the right dose. The drug works by helping the immune system attack cancer cells. This is not a cure, but aims to control the disease.

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Contacts and locations

Locations

  • Assuta Ashdod University Hospital

    Ashdod, Southern District, 7747629, Israel

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • CHU Hôpital Lyon Sud

    Lyon, 69495, France

  • Centre Henri Becquerel

    Rouen, Haute-Normandie, 76038, France

  • Dana Farber Cancer Institute (Massachusetts General Hospital and Beth Israel)

    Boston, Massachusetts, 02215, United States

  • H. Lee Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001, Israel

  • Institut Gustave Roussy

    Villejuif, Île-de-France Region, 94800, France

  • Lady Davis Carmel Medical Center

    Haifa, 3436212, Israel

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Meir Medical Center

    Kfar Saba, Central District, 44281, Israel

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Rambam Health Care Campus - Hematology and Bone Marrow Transplantation Institute

    Haifa, 3109601, Israel

  • Royal Cornwall Hospitals NHS Trust

    Truro, Cornwall, tr1 3lq, United Kingdom

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901, United States

  • Stanford University

    Stanford, California, 94305, United States

  • The Chaim Sheba Medical Center

    Tel-Hashomer, Central District, 5265601, Israel

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • Universitatsklinikum Wurzburg

    Würzburg, Bavaria, 97080, Germany

  • University of California, Irvine

    Orange, California, 92868, United States

  • Weill Cornell Medical College

    New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.