Could less radiation be better for anal cancer? new trial aims to find out
NCT ID NCT05902533
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving a lower dose of radiation to nearby lymph nodes can reduce side effects in people with anal cancer who are also receiving chemotherapy. The trial includes 33 adults with locally advanced anal cancer. The goal is to see if this approach lowers toxicity while still controlling the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation (reduced dose to lymph nodes) combined with chemotherapy drugs capecitabine and mitomycin C
What this could lead to
If successful, this could lead to a new standard of care that reduces painful side effects from radiation for anal cancer patients.
What could go wrong
This is a small, early-phase trial with only 33 participants, so results may not apply to everyone. Lowering radiation might also reduce its ability to control the cancer.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ohio State University Medical Center
Columbus, Ohio, 43210, United States
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University of Cincinnati Medical Center
Cincinnati, Ohio, 45219, United States
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University of Vermont
Burlington, Vermont, 05405, United States