New chemo cocktail plus surgery aims to beat back advanced rectal cancer

NCT ID NCT06048146

First seen Apr 08, 2026 · Last updated Jun 16, 2026 · Updated 10 times

Summary

This study looked at 180 adults with rectal cancer that had spread to lymph nodes in the pelvis. It compared a strong three-drug chemo regimen (FOLFOXIRI) plus surgery to remove those lymph nodes against standard chemo-radiation before surgery. The goal was to see if the new approach could keep cancer from coming back longer and improve survival. Researchers also looked for genetic markers to personalize treatment.

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Contacts and locations

Locations

  • Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College

    Beijing, Beijing Municipality, 100021, China

Conditions

Explore the condition pages connected to this study.