Can chemo before surgery wipe out rectal cancer and liver spread?
NCT ID NCT07467434
First seen Mar 17, 2026 · Last updated Jun 19, 2026 · Updated 10 times
Summary
This study looks at whether giving FOLFIRINOX chemotherapy before surgery helps people with mid or lower rectal cancer that has spread to the liver. The goal is to see if both the rectal tumor and liver spots can be completely removed. 550 adults will take part, and the main result will be checked at 18 months.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Digestive Surgery Department, Bicêtre University Hospital AP-HP
RECRUITINGLe Kremlin-Bicêtre, 94270, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
FOLFIRINOX chemotherapy
What this could lead to
If successful, this approach could show that giving FOLFIRINOX before surgery helps more patients have all their cancer removed completely, potentially improving long-term survival.
What could go wrong
This is an observational study, not a randomized trial, so results may be less definitive. The chemotherapy itself has significant side effects, and not all patients will respond well enough for curative surgery.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.