Can a steroid or a sedative stop the pain when the numbness wears off?
NCT ID NCT07299877
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding dexamethasone (a steroid), dexmedetomidine (a sedative), or both to standard numbing medicine can prevent the intense pain that often occurs when a nerve block wears off after arm surgery. About 75 adults having elective upper limb surgery will be randomly assigned to one of three groups. The main goal is to see how many people experience rebound pain and how severe it is.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dexamethasone and/or dexmedetomidine added to local anesthetics (lidocaine and bupivacaine)
- What this could lead to
- If successful, this could point to a simple way to prevent severe pain after nerve blocks wear off, improving recovery for arm surgery patients.
- What could go wrong
- This is a small, early-phase trial with only 75 participants, so results may not apply to everyone. The drugs may not reduce rebound pain as hoped, and side effects are possible.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Benha University, Faculty of Medicine
Banhā, Qalyubiyya, 300001, Egypt
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