Can electronic health records replicate Gold-Standard cancer trials?

NCT ID NCT07178743

Completed Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed study looked at over 6,000 people with advanced breast cancer to see if information from electronic health records could match the results of a famous clinical trial called PALOMA-2. The goal was not to test a new drug, but to learn whether real-world data can be trusted to answer important medical questions. Researchers compared patients who started a combination of palbociclib and letrozole against those who started letrozole alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that real-world data can reliably reproduce clinical trial results, potentially speeding up future research.
What could go wrong: This is an observational emulation, not a new treatment test. It may not perfectly match the original trial's findings due to data limitations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02120, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.