Can a cream and light combo reverse crepey skin?
NCT ID NCT07686198
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This study tests whether a special serum called Re-Q Pro-Longevity, used twice daily along with intense pulsed light therapy, can improve moderate to severe sun damage and crepiness on the forearms. The trial involves women aged 50 to 80 with fair to medium skin tones. Each participant receives the active serum on one arm and a placebo serum on the other, with both arms getting the light treatment, to see which side shows more improvement.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Re-Q Pro-Longevity serum
- What this could lead to
- If it works, this could point toward a non-invasive way to reduce visible sun damage and skin crepiness on the arms.
- What could go wrong
- This is a small early-phase study with only 20 participants, so results may not apply broadly. The serum is tested alongside a light treatment, making it hard to know which part works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 80 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Female participants aged 50 to 80 years. 2. Fitzpatrick skin types I-IV. 3. Moderate to severe photodamage and crepiness on the arms, based on clinical evaluation, including fine wrinkling, coarse wrinkling, photodamage, and a global assessment as assessed with the 10-point Dermatologic Assessment Form and Photographic Scale 4. Willing and able to comply with all study requirements, including scheduled visits, treatment protocol, and follow-up assessments. 5. Willing to sign an informed consent form and photography release for research, publication, and/or commercial use. 6. In good general health as determined by the investigator based on medical history and clinical judgment. 7. Willing to maintain the study skincare regimen and refrain from introducing new topical or procedural treatments to the forearms during the study period. 8. Negative urine pregnancy test at all visits for participants of childbearing potential. 9. Participants must be of non-childbearing potential, defined as: a. History of hysterectomy or bilateral oophorectomy, or b. No menses for at least 12 consecutive months without an alternative medical cause. Or, if of childbearing potential, must agree to use an effective form of contraception during the course of the study. Acceptable methods include: i. Oral contraceptive pill, injection, implant, patch, vaginal ring, or intrauterine device (IUD) ii. Intrauterine coil iii. Bilateral tubal ligation iv. Hysterectomy v. Barrier method used with an additional form of contraception (e.g., spermicide, sponge, or condom) vi. Abstinence (must agree to use a barrier method if sexual activity begins during the study) vii. Partner with a vasectomy (if not, participant must agree to use a barrier method) Exclusion Criteria: 1. Patients with dark hair in the treatment area who are unwilling to shave the treated area prior to IPL treatments or who are unwilling to proceed knowing IPL will eliminate at least 50% of the hairs in the treatment area 2. A suntan in the treatment area or use of sunless tanner/spray-tan in the treatment areas 4 weeks prior to study treatment 3. Active infection, open wounds, or inflammatory dermatoses (e.g., eczema, psoriasis, dermatitis) in the treatment area. 4. Use of at-home energy-based devices intended for rejuvenation or fibroblastic/collagen stimulation on the treatment area within 30 days prior to treatment and during the study period. 5. Use of GLP-1 medications or metformin within 3 months prior to enrollment 6. Pregnancy, plans to become pregnant during the study period, or current breastfeeding. 7. History of autoimmune connective tissue diseases (e.g., systemic lupus erythematosus, scleroderma, dermatomyositis). 8. Current or recent use (within the past 3 months) of systemic immunosuppressive medications. 9. Any uncontrolled systemic condition that may increase risk or interfere with study participation, including but not limited to poorly managed diabetes, thyroid dysfunction, or cardiovascular disease. 10. Clinically significant neurological, psychological or psychiatric conditions, or any condition that, in the opinion of the investigator, may interfere with study participation or interpretation of results. 11. Active smoking tobacco or use of nicotine-containing products within 6 months prior to enrollment. 12. Participation in any other interventional clinical study within 30 days prior to enrollment or during the course of this study. 13. Unwillingness to refrain from undergoing any additional aesthetic treatments to the arms (e.g., lasers, injectables, energy-based devices, cosmeceuticals, etc.) from screening through the end of the study period. 14. History of keloids or scarring/tattoos in the treatment area
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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West Dermatology Research Center/Cosmetic Laser Dermatology
San Diego, California, 92121, United States
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