New hope for lung cancer: experimental drug RC148 takes on standard therapy

NCT ID NCT07416474

Recruiting now Disease control Sponsor: RemeGen Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study compares two treatments for people with advanced squamous non-small cell lung cancer who have not had prior therapy. Participants will receive either the experimental drug RC148 or the approved drug tislelizumab, both combined with chemotherapy. The goal is to see which combination works better at controlling the cancer and improving survival. About 574 adults aged 18-75 with good performance status are being recruited.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Affiliated Cancer Hospital of Xinjiang University
RECRUITING

Ürümqi, Xinjiang, China
Affiliated Hospital of Binzhou Medical University
RECRUITING

Binzhou, Shandong, China
Affiliated Hospital of Hebei University
RECRUITING

Baoding, China
Affiliated Hospital of Qingdao University
RECRUITING

Qingdao, Shandong, China
Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, China
Anyang Cancer Hospital
RECRUITING

Anyang, Henan, China
Cancer Hospital Affiliated to Chongqing University
RECRUITING

Chongqing, Chongqing Municipality, China
Cancer Hospital Affiliated to Guangxi Medical University
RECRUITING

Nanning, Guangxi, China
Cancer Hospital Affiliated to Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, China
Cancer Hospital Affiliated to Harbin Medical University
RECRUITING

Harbin, Heilongjiang, China
Cangzhou Central Hospital
RECRUITING

Cangzhou, China
Chongqing Medical University First Affiliated Hospital
RECRUITING

Chongqing, Chongqing Municipality, China
Dongguan People's Hospital
RECRUITING

Dongguan, Guangdong, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, China
General Hospital of Ningxia Medical University
RECRUITING

Yinchuan, Ningxia, China
Guizhou Provincial People's Hospital
RECRUITING

Guiyang, Guizhou, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, China
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, China
Hubei Cancer Hospital
RECRUITING

Wuhan, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, China
Jiangmen Central Hospital
RECRUITING

Jiangmen, Guangdong, China
Jiangsu Cancer Hospital
RECRUITING

Nanjing, Jiangsu, China
Jiangsu Provincial People's Hospital
RECRUITING

Nanjing, Jiangsu, China
Jiangxi Cancer Hospital
RECRUITING

Nanchang, Jiangxi, China
Jilin Cancer Hospital
RECRUITING

Changchun, Jilin, China
Jinan Central Hospital
RECRUITING

Jinan, Shandong, China
Liaoning Cancer Hospital
RECRUITING

Shenyang, Liaoning, China
Linyi Cancer Hospital
RECRUITING

Linyi, Shandong, China
Nanyang Second People's Hospital
RECRUITING

Nanyang, Henan, China
Peking Union Medical College Hospital
RECRUITING

Beijing, China
Peking University Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, China
Shanghai Chest Hospital
RECRUITING

Shanghai, China
Shanghai Pulmonary Hospital
RECRUITING

Shanghai, Shanghai Municipality, China
Shanghai Pulmonary Hospital
RECRUITING

Shanghai, China
Shanxi Cancer Hospital
RECRUITING

Taiyuan, Shanxi, China
Shenzhen People's Hospital
RECRUITING

Shenzhen, Guangdong, China
Sichuan Cancer Hospital
RECRUITING

Chengdu, Sichuan, China
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, China
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, China
Sun Yat-sen University First Affiliated Hospital
RECRUITING

Guangzhou, Guangdong, China
Taizhou Hospital of Zhejiang Province
RECRUITING

Taizhou, Zhejiang, China
The Fifth Affiliated Hospital of Sun Yat-sen University
RECRUITING

Zhuhai, Guangdong, China
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, China
The First Affiliated Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, Guangxi, China
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangzhou, China
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, Henan, China
The First Affiliated Hospital of Lanzhou University
RECRUITING

Lanzhou, Gansu, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, China
The First Affiliated Hospital of Soochow University
RECRUITING

Suzhou, Jiangsu, China
The First Affiliated Hospital of Wannan Medical College
RECRUITING

Wuhu, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, China
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, Fujian, China
The First Affiliated Hospital of Xinxiang Medical University
RECRUITING

Xinxiang, Henan, China
The First Affiliated Hospital of Zhengzhou
RECRUITING

Zhengzhou, Henan, China
The First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, China
The First People's Hospital of Chenzhou City
RECRUITING

Binzhou, China
The Fourth Affiliated Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, China
The Second Affiliated Hospital of Air Force Medical University of the Chinese People's Liberation Army
RECRUITING

Xi'an, Shaanxi, China
The Second Affiliated Hospital of Army Medical University of the Chinese People's Liberation Army
RECRUITING

Chongqing, China
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, China
The Second Affiliated Hospital of Guilin Medical University
RECRUITING

Guilin, Guangxi, China
Tianjin Cancer Hospital
RECRUITING

Tianjin, Tianjin Municipality, China
Tianjin Chest Hospital
RECRUITING

Tianjin, Tianjin Municipality, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, China
Union Hospital Affiliated to Fujian Medical University
RECRUITING

Fuzhou, Fujian, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technolo
RECRUITING

Wuhan, China
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, China
Xiangya Hospital of Central South University
RECRUITING

Changsha, China
Xiangyang Central Hospital
RECRUITING

Xiangyang, Hubei, China
Xuzhou Central Hospital
RECRUITING

Xuzhou, Jiangsu, China
Yunnan Cancer Hospital
RECRUITING

Kunming, Yunnan, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, China
Zhongda Hospital Affiliated to Southeast University
RECRUITING

Nanjing, Jiangsu, China
Zhongnan Hospital of Wuhan University
RECRUITING

Wuhan, Hubei, China
Zhujiang Hospital of Southern Medical University
RECRUITING

Guangzhou, Guangdong, China
Zhuzhou Central Hospital
RECRUITING

Zhuzhou, China

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