New combo therapy targets hard-to-treat cancers with RAS mutations
NCT ID NCT07397338
First seen Feb 15, 2026 · Last updated Jun 09, 2026 · Updated 17 times
Summary
This study tests whether combining RAS(ON) inhibitors with ivonescimab (and possibly other drugs) is safe and effective for adults with advanced or metastatic solid tumors that have a RAS mutation. About 370 participants will receive the treatment to check for side effects, drug levels in the blood, and tumor shrinkage. The goal is to find a new option for cancers like lung and colorectal cancer that have not responded to standard therapies.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Eastern Connecticut Hematology and Oncology Associates
RECRUITINGNorwich, Connecticut, 06360, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Dallas
RECRUITINGIrving, Texas, 75039, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tennessee Oncology
RECRUITINGNashville, Tennessee, 37023, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.