New hope for ovarian cancer: targeted drug R-DXd enters key trial

NCT ID NCT06161025

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a new drug called raludotatug deruxtecan (R-DXd) in people with ovarian, peritoneal, or fallopian tube cancer that no longer responds to platinum chemotherapy. The drug is designed to target and kill cancer cells while sparing healthy ones. About 860 participants will be randomly assigned to receive R-DXd or standard chemotherapy. Researchers will measure how well the drug shrinks tumors and delays cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Raludotatug deruxtecan (R-DXd), a targeted antibody-drug conjugate

What this could lead to

If successful, this could offer a new treatment option for people with ovarian cancer that has stopped responding to platinum-based chemotherapy.

What could go wrong

This is an early-to-mid stage trial, so the drug may not work better than current options or could have unexpected side effects. Results are not guaranteed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cancer fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aichi Cancer Center Hospital
RECRUITING

Nagoya, 464-8681, Japan
Alaska Women's Cancer Care
RECRUITING

Anchorage, Alaska, 99508, United States
Arthur J. E. Child Comp CC
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

Seoul, South Korea
Azienda Ospedaliera Per Lemergenza Cannizzaro
ACTIVE_NOT_RECRUITING

Catania, Italy
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Italy
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
RECRUITING

Bologna, 40138, Italy
Baskent University Adana Application and Research Center
RECRUITING

Adana, 01240, Turkey (Türkiye)
Baystate Medical Center
RECRUITING

Springfield, Massachusetts, 01199-1001, United States
Beijing Cancer Hospital
ACTIVE_NOT_RECRUITING

Beijing, China
CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie
RECRUITING

Plérin, 22190, France
CHA Bundang Medical Center, CHA University
RECRUITING

Seongnam-si, South Korea
Cancer Institute Hospital of JFCR
RECRUITING

Kōtoku, 135-8550, Japan
Centre Francois Baclesse
RECRUITING

Caen, 14076, France
Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centre Jean Perrin - CLCC
RECRUITING

Clermont-Ferrand, 63000, France
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Chang Gung Memorial Hospital,Linkou
RECRUITING

Taoyuan City, Taiwan
Chongqing Cancer Hospital
ACTIVE_NOT_RECRUITING

Chongqing, 400030, China
Clinica Universidad de Navarra
ACTIVE_NOT_RECRUITING

Pamplona, Spain
Clinica Universidad de Navarra (MAD)
ACTIVE_NOT_RECRUITING

Pamplona, Spain
Community Health Network - MD Anderson
RECRUITING

Indianapolis, Indiana, 46250, United States
Community MD Anderson Cancer Center- East
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46219, United States
Community MD Anderson Cancer Center- South
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46227, United States
Diagnostic and Therapeutic Centre of Athens "Hygeia" S.A.
RECRUITING

Marousi, 15123, Greece
Duke Cancer Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care- Raleigh
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27607, United States
Fakultni nemocnice Brno
RECRUITING

Brno, 625 00, Czechia
Fakultni nemocnice Bulovka
RECRUITING

Prague, Czechia
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 50005, Czechia
Fakultni nemocnice v Motole
RECRUITING

Prague, 150 06, Czechia
Florida Cancer Specialists
RECRUITING

Lake Mary, Florida, 32746, United States
Fondazione IRCCS San Gerardo dei Tintori di Monza
RECRUITING

Monza, 20900, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, Italy
Froedtert and the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Fudan University Shanghai Cancer Center
ACTIVE_NOT_RECRUITING

Shanghai, 200032, China
Fujian Provincial Cancer Hospital
ACTIVE_NOT_RECRUITING

Fuzhou, 350015, China
GenesisCare North Shore (Oncology)
RECRUITING

St Leonards, Australia
GenesisCare St Andrews Hospital
RECRUITING

Adelaide, 5000, Australia
Groupe Hospitalier Diaconesses - Hôpital De La Croix Saint Simon
RECRUITING

Paris, 75571, France
Guangxi Medical University Cancer Hospital
ACTIVE_NOT_RECRUITING

Nanning, China
Hokkaido University Hospital
RECRUITING

Sapporo, 060-8648, Japan
Holy Name
RECRUITING

Teaneck, New Jersey, 07666, United States
Hospital Clinic de Barcelona
RECRUITING

Barcelona, Spain
Hospital Clínico Universitario Valencia
RECRUITING

Valencia, Spain
Hospital Ernesto Dornelles
RECRUITING

Porto Alegre, 90.160-093, Brazil
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, 90035-001, Brazil
Hospital Professor Doutor Fernando Fonseca, E.P.E.
RECRUITING

Amadora, Portugal
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain
Hospital Universitario Ciudad de Jaen
ACTIVE_NOT_RECRUITING

Jaén, Spain
Hospital Universitario Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Spain
Hospital da Luz
RECRUITING

Lisbon, 1500-650, Portugal
Houston Area Locations- League City
ACTIVE_NOT_RECRUITING

League City, Texas, 77573, United States
Houston Area Locations- Sugar Land
ACTIVE_NOT_RECRUITING

Houston, Texas, 77079, United States
Houston Area Locations- West Houston
ACTIVE_NOT_RECRUITING

Houston, Texas, 77079, United States
Houston Area Locations- Woodlands
ACTIVE_NOT_RECRUITING

Conroe, Texas, 77384, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Hubei Cancer Hospital
ACTIVE_NOT_RECRUITING

Wuhan, 430079, China
Humanitas San Pio X
RECRUITING

Milan, Italy
Hôpital Privé du Confluent
RECRUITING

Nantes, 44277, France
I. U. Cerrahpasa Faculty of Med
RECRUITING

Istanbul, 34153, Turkey (Türkiye)
IASO General Clinic
RECRUITING

Marousi, 15123, Greece
ICL Alexis Vautrin
RECRUITING

Vandœuvre-lès-Nancy, 54500, France
ICO Badalona - Hospital Universitari Germans Trias i Pujol
RECRUITING

Barcelona, 08916, Spain
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, Italy
IRCCS Centro di Riferimento Oncologico
RECRUITING

Aviano, Italy
Institut Bergonié
RECRUITING

Bordeaux, 33076, France
Institut Curie
RECRUITING

Saint-Cloud, 92210, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13273, France
Institut du Cancer de Montpellier
RECRUITING

Montpellier, 34298, France
Instituto COI de Pesquisa
RECRUITING

Rio de Janeiro, 22775-001, Brazil
Istituto Clinico Humanitas
COMPLETED

Rozzano, 20089, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, Italy
Iwate Medical University Hospital
RECRUITING

Shiwa-gun, 028-3695, Japan
Jikei University Hospital
ACTIVE_NOT_RECRUITING

Minatoku, 105-8471, Japan
Kliniken Essen-Mitte
RECRUITING

Essen, 45136, Germany
Koo Foundation Sun Yat-Sen Cancer Center
RECRUITING

Taipei, Taiwan
Kuopio University Hospital
RECRUITING

Kuopio, 70210, Finland
Mazowiecki Szpital Wojewodzki w Siedlcach Sp z o o
RECRUITING

Siedlce, Poland
McGill University Health Centre/Glen Site / Royal Victoria Hospital
RECRUITING

Montreal, Canada
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Medipol University Medical Faculty
RECRUITING

Istanbul, 34214, Turkey (Türkiye)
Mount Sinai Comprehensive Cancer Center
RECRUITING

Miami Beach, Florida, 33140, United States
NHO Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
NHPP Imbert
ACTIVE_NOT_RECRUITING

Bay Shore, New York, 11706, United States
NHPP LHH
ACTIVE_NOT_RECRUITING

New York, New York, 10065, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, China
National University Hospital
RECRUITING

Seoul, 03080, South Korea
Niigata Cancer Center Hospital
RECRUITING

Niigata, 951-8566, Japan
Northwell Health, LLC PRIME
RECRUITING

Lake Success, New York, 11042, United States
Ohio State University Wexner Medical Center
RECRUITING

Hilliard, Ohio, 43026, United States
Oklahoma Cancer Specialists and Research Institute
RECRUITING

Tulsa, Oklahoma, 12967, United States
Oncocentro - Belo Horizonte
RECRUITING

Belo Horizonte, 30360680, Brazil
Oncology Associates of Oregon, P.C.
RECRUITING

Eugene, Oregon, 97401, United States
Osaka International Cancer Institute
RECRUITING

Osaka, 541-8567, Japan
Ospedale Mauriziano Umberto I
RECRUITING

Torino, Italy
Perelman School of Medicine at the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104-4238, United States
Perlmutter Cancer Center at NYU Langone Hospital- Long Island
ACTIVE_NOT_RECRUITING

Mineola, New York, 11501, United States
Qilu Hospital of Shandong University
ACTIVE_NOT_RECRUITING

Jinan, China
Royal United Hospital
ACTIVE_NOT_RECRUITING

Bath, United Kingdom
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, 350-1298, Japan
Samsung Medical Center
RECRUITING

Seoul, South Korea
Sanford Cancer Center Gynecologic Oncology
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Severance Hospital, Yonsei University Health System - Site 8201
RECRUITING

Seoul, 03722, South Korea
Severance Hospital, Yonsei University Health System - Site 8207
RECRUITING

Seoul, 03722, South Korea
Shandong Cancer Hospital
ACTIVE_NOT_RECRUITING

Jinan, 250117, China
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, 411-8777, Japan
St Luke's Hospital
RECRUITING

Thessaloniki, 55236, Greece
St. Elizabeth Medical Center
RECRUITING

Edgewood, Kentucky, 41017, United States
Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
Sylvester Comprehensive Cancer Center at Deerfield Beach
ACTIVE_NOT_RECRUITING

Deerfield Beach, Florida, 33442, United States
Sylvester Comprehensive Cancer Center at Lennar
ACTIVE_NOT_RECRUITING

Coral Gables, Florida, 33146, United States
Sylvester Comprehensive Cancer Center at Plantation
ACTIVE_NOT_RECRUITING

Plantation, Florida, 33324, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Texas Oncology Paris
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology-Bedford
ACTIVE_NOT_RECRUITING

Bedford, Texas, 76022, United States
Texas Oncology-Presbyterian Cancer Center Dallas
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75231, United States
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, South Korea
The First Affiliated Hospital of Guangzhou Medical University
ACTIVE_NOT_RECRUITING

Guangzhou, China
Tianjin Medical University Cancer Institute & Hospital
ACTIVE_NOT_RECRUITING

Tianjin, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
ACTIVE_NOT_RECRUITING

Wuhan, China
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Mannheim
RECRUITING

Mannheim, 68167, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89075, Germany
University Health Network - Princess Margaret Cancer Centre
ACTIVE_NOT_RECRUITING

Toronto, Canada
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Texas - MD Anderson
RECRUITING

Houston, Texas, 77030, United States
University of Virginia Comprehensive Cancer Center
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Washington - Seattle Cancer Care Alliance
RECRUITING

Seattle, Washington, 98109, United States
Uniwersytecki Szpital Kliniczny W Poznaniu
RECRUITING

Poznan, 60-569, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
RECRUITING

Bialystok, 15-276, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, Poland
Valley Health System
RECRUITING

Paramus, New Jersey, 07652, United States
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, Czechia
Washington University School of Medicine Obstetrics and Gynecology
RECRUITING

St Louis, Missouri, 63110, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06520, United States
Zhejiang Cancer Hospital
ACTIVE_NOT_RECRUITING

Hangzhou, 310022, China