New hope for ovarian cancer: targeted drug R-DXd enters key trial

NCT ID NCT06161025

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 6 times

Summary

This study tests a new drug called raludotatug deruxtecan (R-DXd) in people with ovarian, peritoneal, or fallopian tube cancer that no longer responds to platinum chemotherapy. The drug is designed to target and kill cancer cells while sparing healthy ones. About 860 participants will be randomly assigned to receive R-DXd or standard chemotherapy. Researchers will measure how well the drug shrinks tumors and delays cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Raludotatug deruxtecan (R-DXd), a targeted antibody-drug conjugate
What this could lead to: If successful, this could offer a new treatment option for people with ovarian cancer that has stopped responding to platinum-based chemotherapy.
What could go wrong: This is an early-to-mid stage trial, so the drug may not work better than current options or could have unexpected side effects. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aichi Cancer Center Hospital
ACTIVE_NOT_RECRUITING

Nagoya, 464-8681, Japan
Alaska Women's Cancer Care
RECRUITING

Anchorage, Alaska, 99508, United States
Aretaieio Hospital
ACTIVE_NOT_RECRUITING

Athens, 11528, Greece
Arthur J. E. Child Comp CC
ACTIVE_NOT_RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
ACTIVE_NOT_RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliera Per Lemergenza Cannizzaro
ACTIVE_NOT_RECRUITING

Catania, 95126, Italy
Azienda Ospedaliera Universitaria Careggi
ACTIVE_NOT_RECRUITING

Florence, 50134, Italy
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
ACTIVE_NOT_RECRUITING

Bologna, 40138, Italy
Baskent University Adana Application and Research Center
ACTIVE_NOT_RECRUITING

Adana, 01240, Turkey (Türkiye)
Baystate Medical Center
ACTIVE_NOT_RECRUITING

Springfield, Massachusetts, 01199-1001, United States
Beatson West of Scotland Cancer Centre
ACTIVE_NOT_RECRUITING

Glasgow, G12 0YN, United Kingdom
Beijing Cancer Hospital
ACTIVE_NOT_RECRUITING

Beijing, 100142, China
CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie
ACTIVE_NOT_RECRUITING

Plérin, 22190, France
CHA Bundang Medical Center, CHA University
ACTIVE_NOT_RECRUITING

Seongnam-si, 13496, South Korea
Cancer Institute Hospital of JFCR
ACTIVE_NOT_RECRUITING

Kōtoku, 135-8550, Japan
Centre Francois Baclesse
ACTIVE_NOT_RECRUITING

Caen, 14076, France
Centre Georges François Leclerc
ACTIVE_NOT_RECRUITING

Dijon, 21079, France
Centre Jean Perrin - CLCC
ACTIVE_NOT_RECRUITING

Clermont-Ferrand, 63000, France
Centre Leon Berard
ACTIVE_NOT_RECRUITING

Lyon, 69008, France
Chang Gung Memorial Hospital,Linkou
ACTIVE_NOT_RECRUITING

Taoyuan City, 333, Taiwan
Chongqing Cancer Hospital
ACTIVE_NOT_RECRUITING

Chongqing, 400030, China
Churchill Hospital
ACTIVE_NOT_RECRUITING

Headington, OX3 7LE, United Kingdom
Clinica Universidad de Navarra
ACTIVE_NOT_RECRUITING

Pamplona, 31008, Spain
Clinica Universidad de Navarra (MAD)
ACTIVE_NOT_RECRUITING

Pamplona, 31008, Spain
Community Health Network - MD Anderson
RECRUITING

Indianapolis, Indiana, 46250, United States
Community MD Anderson Cancer Center- East
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46219, United States
Community MD Anderson Cancer Center- South
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46227, United States
Cukurova University Medical Faculty
ACTIVE_NOT_RECRUITING

Adana, 01790, Turkey (Türkiye)
Diagnostic and Therapeutic Centre of Athens "Hygeia" S.A.
ACTIVE_NOT_RECRUITING

Marousi, 15123, Greece
Duke Cancer Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care- Raleigh
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27607, United States
Fakultni nemocnice Brno
ACTIVE_NOT_RECRUITING

Brno, 625 00, Czechia
Fakultni nemocnice Bulovka
ACTIVE_NOT_RECRUITING

Prague, 180 81, Czechia
Fakultni nemocnice Hradec Kralove
ACTIVE_NOT_RECRUITING

Hradec Králové, 50005, Czechia
Fakultni nemocnice v Motole
ACTIVE_NOT_RECRUITING

Prague, 150 06, Czechia
Florida Cancer Specialists
RECRUITING

Lake Mary, Florida, 32746, United States
Fondazione IRCCS San Gerardo dei Tintori di Monza
ACTIVE_NOT_RECRUITING

Monza, 20900, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ACTIVE_NOT_RECRUITING

Roma, 00168, Italy
Froedtert and the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Fudan University Shanghai Cancer Center
ACTIVE_NOT_RECRUITING

Shanghai, 200032, China
Fujian Provincial Cancer Hospital
ACTIVE_NOT_RECRUITING

Fuzhou, 350015, China
Fundação Champalimaud
ACTIVE_NOT_RECRUITING

Lisbon, 1400-038, Portugal
GenesisCare North Shore (Oncology)
ACTIVE_NOT_RECRUITING

St Leonards, 2065, Australia
GenesisCare St Andrews Hospital
ACTIVE_NOT_RECRUITING

Adelaide, 5000, Australia
Gold Coast University Hospital
ACTIVE_NOT_RECRUITING

Southport, 4215, Australia
Groupe Hospitalier Diaconesses - Hôpital De La Croix Saint Simon
ACTIVE_NOT_RECRUITING

Paris, 75571, France
Guangxi Medical University Cancer Hospital
ACTIVE_NOT_RECRUITING

Nanning, 530021, China
Hokkaido University Hospital
ACTIVE_NOT_RECRUITING

Sapporo, 060-8648, Japan
Holy Name
RECRUITING

Teaneck, New Jersey, 07666, United States
Hospital Clinic de Barcelona
ACTIVE_NOT_RECRUITING

Barcelona, 08036, Spain
Hospital Clínico Universitario Valencia
ACTIVE_NOT_RECRUITING

Valencia, 46010, Spain
Hospital Ernesto Dornelles
ACTIVE_NOT_RECRUITING

Porto Alegre, 90.160-093, Brazil
Hospital Moinhos de Vento
ACTIVE_NOT_RECRUITING

Porto Alegre, 90035-001, Brazil
Hospital Professor Doutor Fernando Fonseca, E.P.E.
ACTIVE_NOT_RECRUITING

Amadora, 2720-276, Portugal
Hospital Universitari Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe
ACTIVE_NOT_RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
ACTIVE_NOT_RECRUITING

Madrid, 28041, Spain
Hospital Universitario Ciudad de Jaen
ACTIVE_NOT_RECRUITING

Jaén, 23007, Spain
Hospital Universitario Clinico San Carlos
ACTIVE_NOT_RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
ACTIVE_NOT_RECRUITING

Madrid, 28046, Spain
Hospital da Luz
ACTIVE_NOT_RECRUITING

Lisbon, 1500-650, Portugal
Houston Area Locations- League City
ACTIVE_NOT_RECRUITING

League City, Texas, 77573, United States
Houston Area Locations- Sugar Land
ACTIVE_NOT_RECRUITING

Houston, Texas, 77079, United States
Houston Area Locations- West Houston
ACTIVE_NOT_RECRUITING

Houston, Texas, 77079, United States
Houston Area Locations- Woodlands
ACTIVE_NOT_RECRUITING

Conroe, Texas, 77384, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Hubei Cancer Hospital
ACTIVE_NOT_RECRUITING

Wuhan, 430079, China
Humanitas San Pio X
ACTIVE_NOT_RECRUITING

Milan, 20159, Italy
Hyogo Cancer Center
ACTIVE_NOT_RECRUITING

Akashi-shi, 673-8558, Japan
Hôpital Privé du Confluent
ACTIVE_NOT_RECRUITING

Nantes, 44277, France
I. U. Cerrahpasa Faculty of Med
ACTIVE_NOT_RECRUITING

Istanbul, 34153, Turkey (Türkiye)
IASO General Clinic
ACTIVE_NOT_RECRUITING

Marousi, 15123, Greece
ICL Alexis Vautrin
ACTIVE_NOT_RECRUITING

Vandœuvre-lès-Nancy, 54500, France
ICO Badalona - Hospital Universitari Germans Trias i Pujol
COMPLETED

Barcelona, 08916, Spain
IEO Istituto Europeo di Oncologia
ACTIVE_NOT_RECRUITING

Milan, 20141, Italy
IRCCS Centro di Riferimento Oncologico
ACTIVE_NOT_RECRUITING

Aviano, 33081, Italy
Institut Bergonié
ACTIVE_NOT_RECRUITING

Bordeaux, 33076, France
Institut Curie
ACTIVE_NOT_RECRUITING

Saint-Cloud, 92210, France
Institut Paoli Calmettes
ACTIVE_NOT_RECRUITING

Marseille, 13273, France
Institut du Cancer de Montpellier
ACTIVE_NOT_RECRUITING

Montpellier, 34298, France
Instituto COI de Pesquisa
ACTIVE_NOT_RECRUITING

Rio de Janeiro, 22775-001, Brazil
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
ACTIVE_NOT_RECRUITING

Porto, 4200-072, Portugal
Istanbul University Istanbul Medical Faculty
ACTIVE_NOT_RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Istituto Clinico Humanitas
COMPLETED

Rozzano, 20089, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
ACTIVE_NOT_RECRUITING

Naples, 80131, Italy
Iwate Medical University Hospital
ACTIVE_NOT_RECRUITING

Shiwa-gun, 028-3695, Japan
Jikei University Hospital
ACTIVE_NOT_RECRUITING

Minatoku, 105-8471, Japan
Kliniken Essen-Mitte
ACTIVE_NOT_RECRUITING

Essen, 45136, Germany
Koo Foundation Sun Yat-Sen Cancer Center
ACTIVE_NOT_RECRUITING

Taipei, 112, Taiwan
Kuopio University Hospital
ACTIVE_NOT_RECRUITING

Kuopio, 70210, Finland
London Health Sciences Centre (LHSC) - Victoria Hospital
ACTIVE_NOT_RECRUITING

London, N6A5W9, Canada
Mazowiecki Szpital Wojewodzki w Siedlcach Sp z o o
ACTIVE_NOT_RECRUITING

Siedlce, 08-110, Poland
McGill University Health Centre/Glen Site / Royal Victoria Hospital
ACTIVE_NOT_RECRUITING

Montreal, H4A 3J1, Canada
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Medipol University Medical Faculty
ACTIVE_NOT_RECRUITING

Istanbul, 34214, Turkey (Türkiye)
Mount Sinai Comprehensive Cancer Center
RECRUITING

Miami Beach, Florida, 33140, United States
NHO Kyushu Cancer Center
ACTIVE_NOT_RECRUITING

Fukuoka, 811-1395, Japan
NHPP Imbert
ACTIVE_NOT_RECRUITING

Bay Shore, New York, 11706, United States
NHPP LHH
ACTIVE_NOT_RECRUITING

New York, New York, 10065, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
National Cancer Center
ACTIVE_NOT_RECRUITING

Goyang-si, 10408, South Korea
National Cancer Center Hospital
ACTIVE_NOT_RECRUITING

Chūōku, 104-0045, Japan
National Cancer Center Hospital East
ACTIVE_NOT_RECRUITING

Kashiwa-shi, 277-8577, Japan
National Cheng Kung University Hospital
ACTIVE_NOT_RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
ACTIVE_NOT_RECRUITING

Taipei, 100225, Taiwan
Niigata Cancer Center Hospital
ACTIVE_NOT_RECRUITING

Niigata, 951-8566, Japan
Northampton General Hospital (Ph3)
ACTIVE_NOT_RECRUITING

Northampton, NN1 5BD, United Kingdom
Northwell Health, LLC PRIME
RECRUITING

Lake Success, New York, 11042, United States
Ohio State University Wexner Medical Center
RECRUITING

Hilliard, Ohio, 43026, United States
Okayama University Hospital
ACTIVE_NOT_RECRUITING

Okayama, 700-8558, Japan
Oklahoma Cancer Specialists and Research Institute
RECRUITING

Tulsa, Oklahoma, 12967, United States
Oncocentro - Belo Horizonte
RECRUITING

Belo Horizonte, 30360680, Brazil
Oncology Associates of Oregon, P.C.
RECRUITING

Eugene, Oregon, 97401, United States
Osaka International Cancer Institute
ACTIVE_NOT_RECRUITING

Osaka, 541-8567, Japan
Ospedale Mauriziano Umberto I
ACTIVE_NOT_RECRUITING

Torino, 10128, Italy
Perelman School of Medicine at the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104-4238, United States
Perlmutter Cancer Center at NYU Langone Hospital- Long Island
ACTIVE_NOT_RECRUITING

Mineola, New York, 11501, United States
Peter MacCallum Cancer Center
ACTIVE_NOT_RECRUITING

Melbourne, 3000, Australia
Qilu Hospital of Shandong University
ACTIVE_NOT_RECRUITING

Jinan, 250117, China
Royal United Hospital
ACTIVE_NOT_RECRUITING

Bath, BA1 3NG, United Kingdom
Saitama Medical University International Medical Center
ACTIVE_NOT_RECRUITING

Hidaka-shi, 350-1298, Japan
Samsung Medical Center
ACTIVE_NOT_RECRUITING

Seoul, South Korea
Sanford Cancer Center Gynecologic Oncology
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Seoul National University Bundang Hospital
ACTIVE_NOT_RECRUITING

Seongnam, 13620, South Korea
Seoul National University Hospital
ACTIVE_NOT_RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System - Site 8201
ACTIVE_NOT_RECRUITING

Seoul, 03722, South Korea
Severance Hospital, Yonsei University Health System - Site 8207
ACTIVE_NOT_RECRUITING

Seoul, 03722, South Korea
Shandong Cancer Hospital
ACTIVE_NOT_RECRUITING

Jinan, 250117, China
Shizuoka Cancer Center
ACTIVE_NOT_RECRUITING

Nagaizumi-cho, 411-8777, Japan
St Luke's Hospital
ACTIVE_NOT_RECRUITING

Thessaloniki, 55236, Greece
St. Elizabeth Medical Center
RECRUITING

Edgewood, Kentucky, 41017, United States
Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
Sylvester Comprehensive Cancer Center at Deerfield Beach
ACTIVE_NOT_RECRUITING

Deerfield Beach, Florida, 33442, United States
Sylvester Comprehensive Cancer Center at Lennar
ACTIVE_NOT_RECRUITING

Coral Gables, Florida, 33146, United States
Sylvester Comprehensive Cancer Center at Plantation
ACTIVE_NOT_RECRUITING

Plantation, Florida, 33324, United States
Taichung Veterans General Hospital
ACTIVE_NOT_RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital
ACTIVE_NOT_RECRUITING

Taipei, 11217, Taiwan
Texas Oncology Paris
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology-Bedford
ACTIVE_NOT_RECRUITING

Bedford, Texas, 76022, United States
Texas Oncology-Presbyterian Cancer Center Dallas
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75231, United States
The Catholic University of Korea, Seoul St. Mary's Hospital
ACTIVE_NOT_RECRUITING

Seoul, 06591, South Korea
The First Affiliated Hospital of Guangzhou Medical University
ACTIVE_NOT_RECRUITING

Guangzhou, 510120, China
The Ottawa Hospital Cancer Centre
ACTIVE_NOT_RECRUITING

Ottawa, K1H 8L6, Canada
Tianjin Medical University Cancer Institute & Hospital
ACTIVE_NOT_RECRUITING

Tianjin, 453000, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
ACTIVE_NOT_RECRUITING

Wuhan, 430022, China
Universitaetsklinikum Carl Gustav Carus TU Dresden
ACTIVE_NOT_RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Hamburg-Eppendorf (Ph3)
ACTIVE_NOT_RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Mannheim
ACTIVE_NOT_RECRUITING

Mannheim, 68167, Germany
Universitaetsklinikum Ulm
ACTIVE_NOT_RECRUITING

Ulm, 89075, Germany
University College London Hospitals
ACTIVE_NOT_RECRUITING

London, NW1 2PG, United Kingdom
University Health Network - Princess Margaret Cancer Centre
ACTIVE_NOT_RECRUITING

Toronto, M5G 2M9, Canada
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Texas - MD Anderson
RECRUITING

Houston, Texas, 77030, United States
University of Virginia Comprehensive Cancer Center
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Washington - Seattle Cancer Care Alliance
RECRUITING

Seattle, Washington, 98109, United States
Uniwersytecki Szpital Kliniczny W Poznaniu
ACTIVE_NOT_RECRUITING

Poznan, 60-569, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
ACTIVE_NOT_RECRUITING

Bialystok, 15-276, Poland
Uniwersyteckie Centrum Kliniczne
ACTIVE_NOT_RECRUITING

Gdansk, 80-214, Poland
Valley Health System
RECRUITING

Paramus, New Jersey, 07652, United States
Vseobecna fakultni nemocnice v Praze
ACTIVE_NOT_RECRUITING

Prague, 128 08, Czechia
Washington University School of Medicine Obstetrics and Gynecology
RECRUITING

St Louis, Missouri, 63110, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06520, United States
Zhejiang Cancer Hospital
ACTIVE_NOT_RECRUITING

Hangzhou, 310022, China

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