Can stronger radiation tame inoperable rectal cancer without surgery?
NCT ID NCT07721181
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This trial investigates whether giving a higher dose of radiotherapy can safely control locally recurrent rectal cancer that cannot be surgically removed. Around 30 adults with this condition will receive either stereotactic body radiotherapy or hyperfractionated chemo-reirradiation. The goal is to see if this approach is feasible and keeps the cancer in check while limiting side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiotherapy dose escalation (SBRT or hyperfractionated chemo-reirradiation)
- What this could lead to
- If successful, this approach could offer a non-surgical way to control locally recurrent rectal cancer, potentially improving symptom control and delaying disease progression.
- What could go wrong
- This is a small feasibility study, not a large trial. Higher radiation doses carry a risk of serious side effects, and it is unclear whether the benefits will outweigh the risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Catharina Hospital
RECRUITINGEindhoven, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Erasmus Medical Centre
NOT_YET_RECRUITINGRotterdam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radiotherapiegroep
NOT_YET_RECRUITINGArnhem, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rijnstate
NOT_YET_RECRUITINGArnhem, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Medical Centre Utrecht
NOT_YET_RECRUITINGUtrecht, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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