Capsaicin patch trial targets nerve pain in lower back and legs

NCT ID NCT06540456

ENROLLING_BY_INVITATION Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether Qutenza 8% capsaicin skin patches can safely and effectively treat nerve-related lower back pain and leg pain (sciatica). Fifty adults with symptoms lasting over three months will receive up to four patches per visit over five visits in a year. The main goal is to check for side effects and measure changes in pain and quality of life using surveys.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Qutenza 8% capsaicin topical system (skin patch)
What this could lead to: If it works, this could offer a new topical treatment option for people with nerve-related lower back and leg pain, potentially reducing pain and improving quality of life.
What could go wrong: This is a small, early pilot study with only 50 participants, so results may not apply to everyone. Capsaicin can cause skin irritation or burning at the application site.

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Conditions

The condition(s) this trial relates to.

Low Back Pain radiculopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOWER BACK PAIN LUMBOSACRAL RADICULOPATHY

Contacts and locations

Locations

MUSC Health Nexton Medical Park

Summerville, South Carolina, 29483, United States

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